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| 1 | 曲马多治疗糖尿病性神经疼痛的双盲随机试验显示文摘目的 :本研究旨在评价曲马多治疗糖尿病性神经痛的有效性和安全性。背景 :糖尿病性神经痛是糖尿病患者的主要症状 ,其治疗和其他的末梢神经病变一样 ,不能令人满意。曲马多是作用于中枢的镇痛剂 ,用于治疗中到重度疼痛。方法 :多中心、门诊病例、随机、双盲、安慰剂做对照、设置平行组的研究 ,包括清洗期 (在此期间停用所有镇痛剂 )和一个为期 42天的双盲治疗期。总共有 1 31名患糖尿病性神经痛的患者按每日 4次接受了曲马多 (n =65)或看上去与曲马多相同的安慰剂胶囊治疗 (n =66)。 42天的治疗结束后或治疗中断后比较曲马多组和安慰剂组平均疼痛强度评分作出主要有效性分析 ;次要有效性分析为疼痛缓解率评分和根据日常活动和睡眠状况作出的对生活质量的评估。结果 :曲马多平均剂量为 2 1 0mg/天 ,治疗糖尿病性神经痛较安慰剂有显著疗效 (P≤ 0 .0 0 1 )。曲马多组患者生理(P =0 .0 2 )和社会功能 (P =0 .0 4 )的评分显著优于安慰剂组。未发现对睡眠有显著治疗作用。曲马多最常见的不良反应是恶心 ,便秘 ,头疼和嗜睡。结论 | Harati Y Gooch C Swenson M Green D Raskin P Donofrio P Cornblath D Sachdeo R Siu CO Kamin M | 2001 | 中国疼痛医学杂志2001，7，1： | 2 |
| 2 | Long-term outcome of pediatric patients with severe aplastic anemia treated with antithymocyte globulin and cyclosporine 显示文摘 | Scheinberg P Wu CO Nunez O Young NS | 2008 | J Pediatr2008，153，6： | 1 |
| 3 | Laugier-Hunziker syndrome显示文摘 | Lenane P Sullivan DO Keane CO | 2001 | J Eur Acad Dermatol Venereol2001，15，6： | 1 |
| 4 | Improving detection limits for organotin compounds in several matrix water samples by derivatization-headspace-solid- phase microextraction and GC-MS 显示文摘 | SEGOVIA-MARTINEZ L BOUZAS-BLANCO A CAMPINS-FAL- CO P | 2010 | Talanta2010，80，5： | 1 |
| 5 | A pilot trial of pentoxifylline in nonalcoholic steatohepatitis 显示文摘 | Adams LA Zein CO Angulo P | 2004 | Am J Gastroenterol2004，99，12： | 1 |
| 6 | Regulatory volume de- crease in Trypanosoma cruzi involves amino acid efflux and changes in intracellular calcium 显示文摘 | Rohloff P Rodrigues CO Docampo R | 2003 | Mol Biochem Parasitol2003，126，2： | 1 |
| 7 | The relationship between perceived stigma, disclosure patterns, support and distress in new attendees at an infertility clinic显示文摘 | Slade P Neill CO Simpson | 2007 | Human Reproduc- tion2007，22，8： | 1 |
| 8 | Case of propylthiouracil-induced ANCA associated small vessel vasculitis 显示文摘 | Harper L Coekwell P Savage CO | 1998 | Nephrol Dial Transplant1998，13，2： | 1 |
| 9 | The role of glutamine in intensive care unit patients:mechanisms of action and clinical outcome显示文摘 | Coéffier M Déchelotte P | 2005 | Nutr Rev2005，63，2： | 1 |
| 10 | Predicting response to immunosuppressive therapy and survival in severe aplastie anaemia显示文摘 | SCHEINBERG P WU CO NUNEZ O et ol | 2009 | Br J Haematol2009，144，2： | 1 |
| 11 | Lack of antioxidant activity of the antiatherogenic compound L-arginine 显示文摘 | ADAMS M R CO V P ROLAND S | 1999 | Atherosclerosis1999，146，2： | 1 |
| 12 | Prevalence and predictors of esophageal arices in patients with primary sclerosins cholangitis显示文摘 | Zein CO Lindor KD Hngalo P | 2004 | Hepatology2004，39，1： | 1 |
| 13 | Case of propylthiouracil-induce ANCA ssociated small vessel vasculitis显示文摘 | Harper L Cockwell P Savage CO | 1998 | Nephrol Dial Transplant1998，13，： | 1 |
| 14 | Serial office-based intralesional injection of cidofovir in adult -onset recurrent respiratory papillomatosis 显示文摘 | Co J Woo P | 2004 | Ann otol Rhlnol Laryngol2004，113，： | 1 |
| 15 | Predicting response to immunosuppressive therapy and survival in severe aplastic anaemia显示文摘 | Scheinberg P Wu CO Nunez O | 2009 | Br J Haematol2009，144，2： | 1 |
| 16 | Factors affecting response and survival in patients with myelodysplasia treated with immunosuppressive therapy 显示文摘 | Sloand EM Wu CO Greenberg P | 2008 | J Clin Oncol2008，26，15： | 1 |
| 17 | Phenotypic and genotypic events in gastric can -cinogeaesis显示文摘 | Co ea P Shhiao YH | 1994 | Cancer Res1994，54，7： | 1 |
| 18 | Regulation of haptoglobin gene expression in 3T3-L1 adipocytes by eytokines, catecholamines, and PPARgamma 显示文摘 | do Nascimento CO Hunter L Trayhurn P | 2004 | Biochem Biophys Res Commun2004，313，3： | 1 |
| 19 | Predicting response to e therapy and survival in severe aplastic anaemia显示文摘 | Scheinberg P Wu CO Nunez O | 2009 | Br J Haematol2009，144，2： | 1 |
| 20 | Case of propylthiouracil-induced ANCA associated small vessel vasculitis显示文摘 | Harper L Cockwell P Savage CO | 1998 | Nephrol Dial Transplant1998，13，2： | 1 |
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