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| 1 | Comparison of Parallel Kinematic Machines with Three Translational Degrees of Freedom and Linear Actuation显示文摘The development of new robot structures, in particular of parallel kinematic machines(PKM), is widely systematized by different structure synthesis methods. Recent research increasingly focuses on PKM with less than six degrees of freedom(DOF). However, an overall comparison and evaluation of these structures is missing. In order to compare symmetrical PKM with three translational DOF, different evaluation criteria are used. Workspace, maximum actuation forces and velocities, power, actuator stiffness, accuracy and transmission behavior are taken into account to investigate strengths and weaknesses of the PKMs. A selection scheme based on possible configurations of translational PKM including different frame configurations is presented. Moreover, an optimization method based on a genetic algorithm is described to determine the geometric parameters of the selected PKM for an exemplary load case and a prescribed workspace. The values of the mentioned criteria are determined for all considered PKM with respect to certain boundary conditions. The distribution and spreading of these values within the prescribed workspace is presented by using box plots for each criterion. Thereby, the performance characteristics of the different structures can be compared directly. The results show that there is no 'best' PKM. Further inquiries such as dynamic or stiffness analysis are necessary to extend the comparison and to finally select a PKM. | PRAUSE Isabel CHARAF EDDINE Sami CORVES Burkhard | 2015 | Chinese Journal of Mechanical Engineering2015，28，4： | 7 |
| 2 | Intensified intensity-modulated radiotherapy in anal cancer with prevalent HPV p16 positivity显示文摘AIM: To investigate the toxicity and response of intensity-modulated radiotherapy schedule intensified with a simultaneous integrated boost in anal canal cancer.METHODS: From March 2009 to March 2014, we retrospectively analyzed 41 consecutive patients treated with intensity-modulated radiotherapy(IMRT) and concurrent chemotherapy for anal canal squamous cell carcinoma at our center. Radiotherapy was delivered via simultaneous integrated boost(SIB) technique by helical tomotherapy, and doses were adapted to two clinical target volumes according to the tumor-nodemetastasis(TNM) stage: 50.6 Gy and 41.4 Gy in 23 fractions in T1N0, 52.8 Gy and 43.2 Gy in 24 fractionsin T2N0, and 55 Gy and 45 Gy in 25 fractions in all patients with N positive and/or ≥ T3, respectively, to planning target volumes 1 and 2. The most common chemotherapy regimen was 5-fluorouracil and mitomycin-based. Human papilloma virus(HPV) p16 expression was performed by immunohistochemistry and evaluated in the majority of patients. Acute and late toxicity was scored according to CTCAe v 3.0 and RTOG scales.RESULTS: The median follow-up was 30 mo(range:12-71). Median age was 63 years(range 32-84). The stage of disease was: stage Ⅰ in 2 patients, stage Ⅱin 13 patients, stage ⅢA in 12 patients, and stage ⅢB in 14 patients, respectively. Two patients were known to be HIV positive(4.9%). HPV p16 expression status was positive in 29/34(85.3%) patients. The 4-year progression-free survival and overall survival in HPVpositive patients were 78% and 92%, respectively.Acute grade 3 skin and gastrointestinal toxicities were reported in 5% and 7.3% of patients, respectively;patients' compliance to the treatment was good due to a low occurrence of severe acute toxicity, although treatment interruptions due to toxicity were required in 7.3% of patients. At 6 mo from end of treatment,36/40(90%) patients obtained complete response;during follow-up, 5(13.8%) patients presented with disease progression(local or systemic).CONCLUSION: In our experience, intensified SIBIMRT with chemotherapy is very feasible in clinical practice, with excellent results in terms of overall survival and local control. | Liliana Belgioia Stefano Vagge Dario Agnese Stefania Garelli Roberto Murialdo Giuseppe Fornarini Silvana Chiara Fabio Gallo Almalina Bacigalupo Renzo Corvò | 2015 | World Journal of Gastroenterology2015，21，37： | 2 |
| 3 | Mutation in the ampC promoter increasing resistance to β-lactams in a clinical Escherichia coli strain 显示文摘 | Corves S Caroff N Espaze E | 2002 | J Antimicrob Agents Chemother2002，46，： | 1 |
| 4 | Second-generation ver- sus first-generation antipsychotic drugs for schizophrenia a meta-analysis 显示文摘 | Leucht S Corves C Arbter D | 2009 | Lancet2009，373，9657： | 1 |
| 5 | Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis显示文摘 | Stefan Leucht Caroline Corves Dieter Arbter Rolf R Engel Chunbo Li John M Davis | 2009 | The Lancet . 2009 (9657)2009，，9657： | 1 |
| 6 | Second-gener-ation versus first-generation antipsychotie drugs for schizophrenial:a me- ta-analysis 显示文摘 | Leucht S Corves C Arbter D | 2009 | Lancet2009，373，： | 1 |
| 7 | Second-generation versus firstgenerationantipsychotic drugs for schizophrenia: a meta-analysis显示文摘 | Leucht S Corves C Arbter D | 2009 | Lancet2009，373，9657： | 1 |
| 8 | Second -- generation versus first- generation antipsychotic drugs for schizophrenia: A meta-- analysis显示文摘 | Stefan Leucht Caroline Corves Dieter Arbter | 2009 | Lancet2009，373，： | 1 |
| 9 | Antipsychotic combinations vs monotherapy in schizophrenia: a meta-analysis of randomized controlled trials显示文摘 | Correll CU Rummel-Kluge C Corves C | 2009 | Schizophr Bull2009，35，2： | 1 |
| 10 | Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis 显示文摘 | Leucht S Corves C Arbter D | 2009 | lancet2009，373，3： | 1 |
| 11 | Second- genera- tion versus first - generation antipsychotic drugs for schizophrenia:a meta - analysis显示文摘 | Stefan Leucht Caroline Corves Dieter Arbter | 2009 | Lancet2009，373，： | 1 |
| 12 | Second-generation versus first-generation antipsychotie drugs for schizophrenia: a meta-analysis显示文摘 | Leucht S Corves C Arbter D | 2009 | Lancet JT-Lancet2009，373，9657： | 1 |
| 13 | second-generation versusfirst-generation antipsychotic drugs for schizophrenia:a meta-analysis显示文摘 | Leucht S Corves C Arbter D | | 0，，9657： | 1 |
| 14 | Second-generation versus first-generation antipsychotic drugs for schizophrenia:a meta-analysis显示文摘 | Leucht S Corves C Arbter D | 2009 | Lancet2009，373，9657： | 1 |
| 15 | Second-generation versus first- generation antipsychotic drugs for schizophrenia:a meta-analysis 显示文摘 | Leucht S Corves C Arber D | 2009 | Lancet2009，373，： | 1 |
| 16 | Second-generation versus first-generation antipsychotic drugs for schizophrenia: a recta- analysis显示文摘 | Leucht S Corves C Arbter D | 2009 | Lancet2009，373，9657： | 1 |
| 17 | Second-generation versus first- generation antipsychotic drugs for schizophrenia: a meta-analysis 显示文摘 | Leucht S Corves C Arbter D | 2009 | Lancet2009，373，9657： | 1 |
| 18 | Second - generation versus first- generation antipsychotic drugs for schizophrenia: a meta-analysis 显示文摘 | Leucht S Corves C Arbter D | 2009 | Lancet2009，373，： | 1 |
| 19 | Teaching mechanism theory - from hands-on analysis to virtual modeling显示文摘 | BAREJ M HOSING M CORVES B | 2001 | Mechanism and Machine Science Springer Dortrecht Heidelberg New York London2001，7，： | 1 |
| 20 | Second-generation versus first-generation antipsychotic drugs for schizophrenia:a meta-analysis显示文摘 | Leucht S Corves C Arbter D | 2009 | Lancet2009，373，9657： | 1 |
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