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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Differences in standing balance between patients with diplegic and hemiplegic cerebral palsy显示文摘Maintaining standing postural balance is important for walking and handling abilities in patients with cerebral palsy.This study included 23 patients with cerebral palsy(seven with spastic diplegia and16 with spastic hemiplegia),aged from 7 to 16 years of age.Standing posture balance measurements were performed using an AMTI model OR6-7 force platform with the eyes open and closed.Patients with diplegic cerebral palsy exhibited greater center of pressure displacement areas with the eyes open and greater center of pressure sway in the medial-lateral direction with the eyes open and closed compared with hemiplegic patients.Thus,diplegic patients exhibited weaker postural balance control ability and less standing stability compared with hemiplegic cerebral palsy patients. | Valeska Gatica Rojas Guillermo Méndez Rebolledo Eduardo Guzman Muoz Natalia Ibarra Cortés Caterine Berrios Gaete Carlos Manterola Delgado | 2013 | Neural Regeneration Research2013，8，26： | 6 |
| 3 | Management of Helicobacter pylori infection in Latin America: A Delphi technique-based consensus显示文摘AIM: To optimize diagnosis and treatment guidelines for this geographic region, a panel of gastroenterologists, epidemiologists, and basic scientists carried out a structured evaluation of available literature.METHODS: Relevant questions were distributed among the experts, who generated draft statements for consideration by the entire panel. A modified three-round Delphi technique method was used to reach consensus. Critical input was also obtained from representatives of the concerned medical community. The quality of the evidence and level of recommendation supporting each statement was graded according to United States Preventive Services Task Force criteria.RESULTS: A group of ten experts was established. The survey included 15 open-ended questions that were distributed among the experts, who assessed the articles associated with each question. The levels of agreement achieved by the panel were 50% in the first round, 73.3% in the second round and 100% in the third round. Main consensus recommendations included:(1) when available, urea breath and stool antigen test(HpSA) should be used for non-invasive diagnosis;(2) detect and eradicate Helicobacter pylori(H. pylori) in all gastroscopy patients to decrease risk of peptic ulcer disease, prevent o retard progression in patients with preneoplastic lesions, and to prevent recurrence in patients treated for gastric cancer;(3) further investigate implementation issues and health outcomes of H. pylorieradication for primary prevention of gastric cancer in high-risk populations;(4) prescribe standard 14-d triple therapy or sequential therapy for first-line treatment;(5) routinely assess eradication success post-treatment in clinical settings; and(6) select second- and third-line therapies according to antibiotic susceptibility testing.CONCLUSION: These achievable steps toward better region-specific management can be expected to improve clinical health outcomes. | Antonio Rollan Juan Pablo Arab M Constanza Camargo Roberto Candia Paul Harris Catterina Ferreccio Charles S Rabkin Juan Cristóbal Gana Pablo Cortés Rolando Herrero Luisa Durán Apolinaria García Claudio Toledo Alberto Espino Nicole Lustig Alberto Sarfatis Catalina Figueroa Javier Torres Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，31： | 2 |
| 4 | An integrated analysis of an orogen sedimentary basin pair: Latest Cretaceous-Cenozoic evolution of the linked Eastern Cordillera orogen and the Llanos foreland basin of Colombia显示文摘 | Bayona G Cortes M Jaramillo C | 2008 | GSA Bulletin2008，120，9： | 1 |
| 5 | Predictive control in power electronics and drives显示文摘 | Cortes P Kazmierkowski M P Kennel R M | 2008 | IEEE Transactions on Industrial Electronics2008，55，12： | 1 |
| 6 | Uniqueness and boundary behaviour of large solutions to elliptic problems with singular weights显示文摘 | Chuaqui M Cortázar C Elgueta M | 2004 | CPAA2004，3，4： | 1 |
| 7 | Impact of glomerular filtration rate on urinary BNP and NT-proBNP levels in heart failure显示文摘 | CORTS R PORTOLS M ROSELL-LLETE | 2012 | Pep-tides2012，33，： | 1 |
| 8 | Tyrosine kinase inhibitors in acute and chronic leukemias显示文摘 | OHANIAN M CORTES J KANTARJIAN H | 2012 | Expert Opin Pharmacother2012，13，7： | 1 |
| 9 | The whole relationship between environmental variables and finn performance: competitive advantage and firm resources as mediator variables 显示文摘 | LOPEZ- GAMERO M D MOLINA -AZORIN J F CLAVER- CORTeS E | 2009 | Journal of environmental management2009，90，10： | 1 |
| 10 | Identification and proteolytic processing of procardosin A显示文摘 | Ramalho-Santos M Verissimo P Cortes L | 1998 | Eur J Biochem1998，255，1： | 1 |
| 11 | The value of simple microbi- ological studies for on-site screening of acute neonatal conjunctivitis in Angola 显示文摘 | Alexandre 1 Cortes N Justel M | 2014 | J Ophthalmic Inflamm Inft2014，4，1： | 1 |
| 12 | Time paths in the diffusion of product Innovations显示文摘 | Cort M K | 1982 | Economic Journal1982，92，9： | 1 |
| 13 | The CD8alpha gene locus is regulated by the Ikaros family of proteins显示文摘 | Harker N Naito T Cortes M | 2002 | Mol Cell2002，10，1： | 1 |
| 14 | Mapping 137Cs deposition: Data validation methods and data interpretation 显示文摘 | Dubois G De Cort M | 2001 | Journal of Environmental Radioactivity2001，53，3： | 1 |
| 15 | Differentialgene expression profile in omental adipose tissue in women withpolycystic ovary syndrome显示文摘 | Cortón M Botella-carretero JI Benguría A | 2007 | J Clin Endocrinol Metab2007，92，1： | 1 |
| 16 | Mapping 137Cs deposition:data validation methods and data interpretation显示文摘 | DUBOIS G DE CORT M | 2001 | Journal of Environmental Radioactivity2001，53，3： | 1 |
| 17 | Antihis- tone and anti - double - stranded deoxyribonucleic acid antibodies are associated with renal disease in systemic lupus erythematosus 显示文摘 | Cortes - Hernandez J Ordi - Ros J Labrador M | 2004 | Am J Med2004，116，3： | 1 |
| 18 | Three dimensional architecture of membrane embedded MscS in the closed conformation显示文摘 | Vasquez V Sotomayor M Cortes D M | | 0，，： | 1 |
| 19 | Key pa- rameter for tensile and compressive strength of fiber-re- inforced soil-lime mixtures 显示文摘 | CONSOLI N C CORTE M B FESTUGATO L | 2012 | Geosynthetics Interna- tional2012，19，5： | 1 |
| 20 | 显示文摘 | CORT(E)S-J(A)COME M A ESCOBAR J ANGELES CH(A)VEZ C LPEZ-SALINAS E ROMERO E FERRAT G TOLEDO-ANTONIO J A | 2008 | Catal Today2008，130，1： | 1 |
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