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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Interferon alfa2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C显示文摘 | McHutchison JG Gordon SC Schiff ER Shiffrnan ML Lee WM Rustgi VK Goodman ZD Ling MH Cort S Albrecht JK | | 0，，： | 1 |
| 3 | Cyanide bystander effect of the linamarase/linamarin killer-suicide gene therapy system显示文摘 | Cortes ML Garcia-Escudero V Hughes M | 2002 | J Gene Med2002，4，： | 1 |
| 4 | Cancer gene therapy by thyroid hormone-mediated expression of toxin genes显示文摘 | Martin V Cortes ML de Felipe P | 2000 | Cancer Res2000，60，12： | 1 |
| 5 | Cancer gene therapy by thyroid hormone-mediated expression of toxin genes显示文摘 | Martin V Cortes ML de Felipe P el al | 2000 | CancerRes2000，60，12： | 1 |
| 6 | Cyanide bystander effect of the linamarase/linamarin killer suicide gene therapy system 显示文摘 | Cortes ML GarciaEscudeor V Hughes M | 2002 | Gene Med2002，4，4： | 1 |
| 7 | Cyanide bystander effect of the linamarase/linamarin killer-suicide gene therapy system显示文摘 | Cortes ML Garcia-Escudero V Hughes M | 2002 | Gene Med2002，4，4： | 1 |
| 8 | Improved prognosis after using mild hypothermia to treat c;ardiorespiratory ar- rest due to a ardiac cause:comparison with a control group显示文摘 | Castrejon S Cortes M Salto ML et a/ | 2009 | Re'' Esp Cardiol2009，62，7： | 1 |
| 9 | Gene therapy in brain tumours: implications of the size of glioblastoma on its curability 显示文摘 | Izquierdo M Cortes ML Martin V | 1997 | Acta Neurochir Suppl1997，68，： | 1 |
| 10 | Successful use of a plant gene in the treatment of cancer in vivo显示文摘 | Cortes ML de Felip P Martin V | 1998 | Gene Therapy1998，5，11： | 1 |
| 11 | Sternal osteomyelitis andscrofuloderma due to BCG vaccination显示文摘 | Corrales IF Cortes JA Mesa ML | 2003 | Biomedica2003，23，： | 1 |
| 12 | Anti-tumoral action of cannabinoids:involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation显示文摘 | Galve-Roperh I Snchez C Cortés ML | 2000 | Nat Med2000，6，3： | 1 |
| 13 | Cyanide bystander effect of the linamarase/linamarin killer-suicide gene therapy system显示文摘 | GarciaEscudero V Hughes M | 2002 | J Gene Med2002，4，4： | 1 |
| 14 | Cyanide bystander effect of the Linamarase/linamarin killer-suicide gene therapy system 显示文摘 | Cortes ML Garcia-Escudero V Hughes M | 2002 | Gene Med2002，4，4： | 1 |
| 15 | Cancer gene therapy by thyroid hormone-mediated expression of toxin genes显示文摘 | Cortes ML de Felipe P | 2000 | Cancer Res2000，60，12： | 1 |
| 16 | Successful use of a plant gene in the treatment of cancer in vivo显示文摘 | Cortes ML P de Felipel | 1998 | Gene Therapy1998，5，： | 1 |
| 17 | Successful use of a plant gene in the treatment of cancer in vivo 显示文摘 | Cortes ML de Felipe P Martin V etal | 1998 | Gene Ther1998，5，11： | 1 |
| 18 | Gene therapy in brain tumors: implications of the size of glioblastoma on its curability显示文摘 | Izquierdo M Cort ML Mart V | 1997 | Acta Neurochir Supple(wien)1997，68，5： | 1 |
| 19 | Cyanide bystander effect of the linamarase/linamarin killer'suicide gene therapy system显示文摘 | Cortes ML Garcia-Escudero V Hughes M | 2002 | Gene Med2002，4，4： | 1 |
| 20 | Intravitreal bevacizumab therapy for neovascular age-related macular degeneration:A pilot study显示文摘 | Abrahám-Marin ML Cortés-Luna CF (A)lvarez-Rivera G | 2007 | Graefe''s Arch Clin Exp Ophthalmol2007，245，5： | 1 |
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