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| 1 | Diabetic gastroenteropathy:An underdiagnosed complication显示文摘This article is an extensive review that provides an update on the pathophysiology,symptoms,diagnosis,and treatment of diabetic gastroenteropathy.There is no reported prevalence,but it has been described that patients with type 1 diabetes have a cumulative incidence at 10 years of 5.2%,and type 2 patients,1%.Also,in the group of type 1 diabetes,it has been observed that women are more likely to present this condition(5.8%vs 3.5%).Many factors are associate with its development(e.g.,hyperglycemia,vagal dysfunction,loss of expression of neural nitric oxide synthase in the myenteric plexus,alterations in the Cajal interstitial cell network,and oxidative stress).Gastrointestinal discomfort could be perceived 70% higher in diabetic patients,describing that 25%of diabetic patients experience gastrointestinal symptoms.Diabetic enteropathy could affect any portion of the gastrointestinal tract,but esophageal alterations were described in more than 60% of diabetic patients,also 60% of them present constipation,and 20%,diarrhea.Gastric emptying scintigraphy is useful to evaluate gastroparesis,therefore,gastric retention of more than 60%at 2 h has a sensitivity of 100% and specificity of 20% for diagnosis;however,other studies such as breath tests,with a sensitivity of 89% and a specificity of 80%,or the endoscopic capsule contribute to the diagnosis.There is no cure;however,management must be multidisciplinary,focused on slowing the progression of diabetic gastroenteropathy,reducing symptoms,and restoring function;that includes nutritional recommendation,maintain glucose levels kept below 180 mg/dL,use of prokinetics,anti-emetics;nowadays,it has been special interest in surgical treatment,such as pyloroplasty,also gastric electrical stimulation appears to be another alternative. | Marcio JoséConcepción Zavaleta Jhean Gabriel Gonzáles Yovera Diego Martín Moreno Marreros Luciana del Pilar Rafael Robles Kely Roxana Palomino Taype Karen Nohelly Soto Gálvez Luis Fernando Arriola Torres Julia Cristina Coronado Arroyo Luis Alberto Concepción Urteaga | 2021 | World Journal of Diabetes2021，12，6： | 4 |
| 2 | CagA EPIYA polymorphisms in Colombian Helicobacter pylori strains and their influence on disease-associated cellular responses显示文摘AIM: To investigate the influence of the CagA diversity in Helicobacter pylori (H. pylori ) strains from Colombia on the host cell biology. METHODS: Eighty-four H. pylori-cagA positive strains with different Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs patterns, isolated from patients with gastritis (n=17), atrophic gastritis (n=17), duodenal ulcer (n=16), intestinal metaplasia (n=16) and gastric cancer (n=18), were included. To determine the integrity of the cag pathogenicity island (cag PAI) we evaluated the presence of cagA, cagT, cagE, and cag10 genes by polymerase chain reaction. AGS gastric epithelial cellswere infected with each strain and assayed for translo-cation and tyrosine phosphorylation of CagA by western blot, secretion of interleukin-8 (IL-8) by enzyme-linked immuno sorbent assay after taking supernatants from cocultures and cell elongation induction. For cell elongation quantification, coculture photographs were taken and the proportion of 'hummingbird' cells (>15 μm) was determined. RESULTS: Overall 72% (60/84) of the strains were found to harbor a functional cag PAI. Levels of phos-phorylated CagA were significantly higher for isolates from duodenal ulcer than the ones in strains from gas-tritis, atrophic gastritis, intestinal metaplasia and gastric cancer (49.1% ± 23.1% vs 21.1% ± 19.5%, P < 0.02; 49.1% ± 23.1% vs 26.2%±14.8%, P<0.045; 49.1% ± 23.1% vs 21.5% ± 19.5%, P<0.043 and 49.1% ± 23.1% vs 29.5% ± 27.1%, P < 0.047 respectively). We observed variable IL-8 expression levels ranging from 0 to 810 pg/mL and from 8.8 to 1442 pg/mL at 6 h and 30 h post-infection, respectively. cagPAI-defective strains did not induce detectable levels of IL-8 at 6 h post-infection. At 30 h post-infection all strains induced IL-8 expression in AGS cells, although cagPAI-defective strains induced significantly lower levels of IL-8 than strains with a functional cagPAI (57.1 ± 56.6 pg/mL vs 513.6 ± 338.6 pg/mL,P < 0.0001). We did not observe differences in the extent of cell elongation induction between strains with a functional or a defective cagPAI in 6 h cocultures. At 24 h post infection strains with functionalcagPAI showed high diversity in the extent of hummingbird phenotype induction ranging from 7% to 34%. cag PAI defective strains induced significantly lower levels of elongation than strains with functional cag-PAI with one or more than one EPIYA-C motif (15.1% ± 5.2%vs 18.9% ± 4.7%,P < 0.03; and 15.1% ± 5.2% vs 20.0% ± 5.1%, P < 0.003 respectively). No differences were observed in cellular elongation inductionor IL-8 expression among H. pylori strains bearing one and more than one EPIYA-C motifs, neither at 6 h nor at 24 h of coculture. There were no associations between the levels of induction of cell elongation or IL-8 expression and number of EPIYA motifs or pathology. CONCLUSION: The present work describes a lack of association between H. pylori CagA protein EPIYA motifs variations from Colombian isolates and disease-associated cellular responses. | Carlos Alberto Fajardo Andrés Javier Quiroga Andrea Coronado Karen Labrador Nicole Acosta Pilar Delgado Carlos Jaramillo María Mercedes Bravo | 2013 | World Journal of Gastrointestinal Oncology2013，5，3： | 3 |
| 3 | 生理性线粒体破碎是心脏适应能量需求增加的正常现象显示文摘线粒体在心脏中起着双重作用:负责满足能量需求和调节细胞凋亡。通常认为,线粒体的分裂和碎裂是病理性应激(如缺血)的结果,是线粒体质量差的指标,并导致线粒体自噬和细胞死亡。然而,最近的研究表明,抑制裂变也导致线粒体功能减弱和心脏损害,说明裂变对维持心脏和线粒体生物能量平衡十分重要。 | 刘莉 叶鹏 Coronado M Fajardo G Nguyen K Zhao M Kooiker KB Jung G Hu DQ Reddy S Sandoval E Stotland A Gottlieb RA Bernstein D | 2018 | 中华高血压杂志2018，26，1： | 2 |
| 4 | Polyoxometalate-based molecularmaterials 显示文摘 | Coronado E Gomez-Garcia C J | 1998 | Chem Rev1998，98，1： | 1 |
| 5 | Solvent removal from water with hydrophobic aerogels 显示文摘 | HRUBESH L W CORONADO P R SATCHER J H | 2001 | J Non-Cryst Solids2001，285，32： | 1 |
| 6 | Magnetic properties of ferrimagnetic chains显示文摘 | Drillon M Coronado E Beltran D | 1986 | J Magn Magn Mater1986，5457，： | 1 |
| 7 | 查看详情显示文摘 | Coronado E Gomez-Garcia C | | 0，，： | 1 |
| 8 | Th2 regulation of viral myocarditis in mice: different roles for TLR3 versus TRIF in progres- sion to chronic disease 显示文摘 | Abston ED Coronado MJ Bucek A | 2012 | Clin Dev Immuno12012，2012，12： | 1 |
| 9 | Clinical features, triage, and outcome of patients presenting to the ED with suspected acute coronary syndromes but without pain: a multicenter study显示文摘 | Coronado BE Pope IH Griffith JL | 2004 | Am J Emer Med2004，22，7： | 1 |
| 10 | NCI thesaurus: a semantic model integrating cancer-related clinical and molecular information显示文摘 | Sioutos Nicholas de Coronado Sherri | 2007 | Journal of Biomedical Informatics2007，40，1： | 1 |
| 11 | Metal complexes of a picolinate-based nitronyl nitroxide free radical显示文摘 | Coronado E Gimenez-Saiz C M Romero F | 2009 | Inorg Chem2009，48，： | 1 |
| 12 | ·8H2O(M=Mn,Cd):A novel type of two-dimensional magnetic lattice显示文摘 | Juan J B Coronado E Carlos J G | 1993 | Angew Chem Int Ed Engl1993，32，： | 1 |
| 13 | Influence of the structural characteristics of Ti1-xSnxO2 nanoparticles on their photocatalytic activity for the elimination of methylcyclohexane vapors显示文摘 | Fresno F Coronado J A Tudela D | 2005 | Applied Catalysis B: Environmental2005，55，3： | 1 |
| 14 | 查看详情显示文摘 | Coronado E Gomez-Garcia C | | 0，，： | 1 |
| 15 | Nuevos procesos de metropolización facilitados por la Alta Velocidad Ferroviaria显示文摘 | Ure?a J M Garmendia M Coronado J M | 2009 | CyTET LXI2009，，160： | 1 |
| 16 | Influence of the structural characteristics of Ti1-xSnxO2 nanoparticles on their photocatalytic activity for the elimination of ethylcyclohexane vapors显示文摘 | Fresno F Coronado J M Tudela D | 2005 | Applied Catalysis B2005，55，： | 1 |
| 17 | Towards an ART based mathematical editor,that uses on-line handwritten symbol recognition显示文摘 | Y A Dimitriadis J L Coronado | 1995 | Pattern Recognition1995，28，6： | 1 |
| 18 | From 1-D to 3-D ferrimagnets in the EDTA family:magnetic characterization of the tetrahydrate series MtM(M'EDTA)2·4H2O显示文摘 | Sapina F Coronado E Beltran D | 1991 | J Am Chem Soc1991，113，： | 1 |
| 19 | Science-technology flows in Spanish re- gions:An analysis of scientific citations in patents 显示文摘 | Acosta M Coronado D | 2003 | Research Policy2003，32，10： | 1 |
| 20 | The importance of tamoxifen metabolism in tamoxifen-stimulated breast tumor growth显示文摘 | C. Kent Osborne Michael Jarman Ray McCague Ester B. Coronado Susan G. Hilsenbeck Alan E. Wakeling | 1994 | Cancer Chemotherapy and Pharmacology1994，，2： | 1 |
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