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| 1 | Apple whole genome sequences:recent advances and new prospects显示文摘In 2010,a major scientific milestone was achieved for tree fruit crops:publication of the first draft whole genome sequence(WGS)for apple(Malus domestica).This WGS,v1.0,was valuable as the initial reference for sequence information,fine mapping,gene discovery,variant discovery,and tool development.A new,high quality apple WGS,GDDH13 v1.1,was released in 2017 and now serves as the reference genome for apple.Over the past decade,these apple WGSs have had an enormous impact on our understanding of apple biological functioning,trait physiology and inheritance,leading to practical applications for improving this highly valued crop.Causal gene identities for phenotypes of fundamental and practical interest can today be discovered much more rapidly.Genome-wide polymorphisms at high genetic resolution are screened efficiently over hundreds to thousands of individuals with new insights into genetic relationships and pedigrees.High-density genetic maps are constructed efficiently and quantitative trait loci for valuable traits are readily associated with positional candidate genes and/or converted into diagnostic tests for breeders.We understand the species,geographical,and genomic origins of domesticated apple more precisely,as well as its relationship to wild relatives.The WGS has turbo-charged application of these classical research steps to crop improvement and drives innovative methods to achieve more durable,environmentally sound,productive,and consumer-desirable apple production.This review includes examples of basic and practical breakthroughs and challenges in using the apple WGSs.Recommendations for“what’s next”focus on necessary upgrades to the genome sequence data pool,as well as for use of the data,to reach new frontiers in genomics-based scientific understanding of apple. | Cameron P.Peace Luca Bianco Michela Troggio Eric van de Weg Nicholas P.Howard Amandine Cornille Charles-Eric Durel Sean Myles ZoëMigicovsky Robert J.Schaffer Evelyne Costes Gennaro Fazio Hisayo Yamane Steve van Nocker Chris Gottschalk Fabrizio Costa David Chagné Xinzhong Zhang Andrea Patocchi Susan E.Gardiner Craig Hardner Satish Kumar Francois Laurens Etienne Bucher Dorrie Main Sook Jung Stijn Vanderzande | 2019 | Horticulture Research2019，6，1： | 3 |
| 2 | Photoinduced electron- transfer processes along molecular wires based on phenylenevinylene oligomers: a quantum - chemical insight显示文摘 | Pourtois G Beljonne D Cornil J | 2002 | J Am Chem Soc2002，，124： | 1 |
| 3 | Bulk and fine chemicals via aqueous biphasic catalysis显示文摘 | Cornils B | 1999 | J Mol Catal A1999，143，1： | 1 |
| 4 | Interchain interactions in organic w-conjugated materials: impact on electronic structure, optical response, and charge transport 显示文摘 | CORNIL J BELJONNE D CALBERT J-P | 2001 | Adv Mater2001，13，： | 1 |
| 5 | Electronic structure of phenylene vinylene oligomers: influence of donor/acceptor substitutions 显示文摘 | CORNIL J DOSSANTOS D A BELJONNE D | 1995 | Journal physical chemistry1995，99，15： | 1 |
| 6 | Effect of propylene glycol supplementation around parturition on milk yield,reproduction performance and some hormonal and metabolic characteristics in dairy cows显示文摘 | Formigoni A Cornil M C Prandi A | | 0，，01： | 1 |
| 7 | Charge transport versus optical properties in semiconducting crystalline organic thin films显示文摘 | Cornil J Calbert J Beljonne D | 2000 | Adv Mater2000，12，： | 1 |
| 8 | Infliximab Induces Potent Anti-Inflammatory and Local Immunomodulatory Activity But no Systemic Immune Suppression in Patients with Crohn's Disease显示文摘 | CORNILIC F SHCALY D DHAENS G | 2001 | Aliment Pharmacol Ther2001，15，4： | 1 |
| 9 | 显示文摘 | COROPCEANU V CORNIL J DA SILVA FILHO D A | 2007 | Chem Rev2007，107，： | 1 |
| 10 | Relationships between Identity Formation and Computer Use among Black and White Emerging Adult Females显示文摘 | Mullis R L Mullis A K Cornille T A | 2007 | Computers in Human Behavior2007，23，1： | 1 |
| 11 | Progress in hydroformylation and carbonylation显示文摘 | BELLER M CORNILS B FROHNING C D | 1995 | J Mol Catal A:Chem1995，104，1： | 1 |
| 12 | Water-soluble catalysts improve hydroformylation of olefins显示文摘 | Wiebus E Cornils B | 1996 | Hydrocarborn Process1996，75，3： | 1 |
| 13 | Adenocarcinoma of the urachus显示文摘 | Cornil C Reynolds CT Kickham CJE | 1967 | J Urol1967，98，： | 1 |
| 14 | Industrial aspects of aqueous catalysis显示文摘 | Cornils B Herrmann W F Eckl R W | 1997 | J Mol Catal A1997，116，12： | 1 |
| 15 | Joint Experimental and Theoretical Characterization of the Electronic Structure of 4, 4 '-Bis (N-m-tolyl-N-phenylamino) biphenyl (TPD) and Substituted Derivatives显示文摘 | Cornil J Gruhn N E Dos Santos D A | 2001 | The Journal of Physical Chemistry A2001，105，21： | 1 |
| 16 | Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH. | Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet | 2022 | Bone Research2022，10，1： | 1 |
| 17 | Prognostic value of total dose and dose intensity of methatrexate in multi-drug treatment of osteosarloma显示文摘 | Delepine N Cornille H Delepine G | 1994 | Am Soc Clin Oncol1994，12，： | 1 |
| 18 | Fluorous biphase systems-the new phase-separation and immobilization technique显示文摘 | Cornils B | 1997 | Chem Int Ed Engl1997，36，19： | 1 |
| 19 | Carcinoma of the urachus显示文摘 | Cornil C | 1967 | J Urol1967，98，1： | 1 |
| 20 | Water-soluble catalysts improve hydroformylation of olefins 显示文摘 | Wiebus E Cornils B | 1996 | Hydrocarbon Process1996，75，3： | 1 |
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