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| 1 | Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets显示文摘AIM: To investigate the effect of protein-energy malnutrition on intestinal barrier function during rotavirus enteritis in a piglet model.METHODS: Newborn piglets were allotted at day 4 of age to the following treatments:(1) full-strength formula(FSF)/noninfected;(2) FSF/rotavirus infected;(3) half-strength formula(HSF)/noninfected;or(4) HSF/rotavirus infected.After one day of adjustment to the feeding rates,pigs were infected with rotavirus and acute effects on growth and diarrhea were monitored for 3 d and jejunal samples were collected for Ussingchamber analyses.RESULTS: Piglets that were malnourished or infected had lower body weights on days 2 and 3 post-infection(P < 0.05).Three days post-infection,marked diarrhea and weight loss were accompanied by sharp reductions in villus height(59%) and lactase activity(91%) and increased crypt depth(21%) in infected compared with non-infected pigs(P < 0.05).Malnutrition also increased crypt depth(21%) compared to full-fed piglets.Villus:crypt ratio was reduced(67%) with viral infection.There was a trend for reduction in transepithelial electrical resistance with rotavirus infection and malnutrition(P = 0.1).3H-mannitol flux was significantly increased(50%;P < 0.001) in rotavirus-infected piglets compared to non-infected piglets,but there was no effect of nutritional status.Furthermore,rotavirus infection reduced localization of the tight junction protein,occludin,in the cell membrane and increased localization in the cytosol.CONCLUSION: Overall,malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model. | Sheila K Jacobi Adam J Moeser Anthony T Blikslager J Marc Rhoads Benjamin A Corl Robert J Harrell Jack Odle | 2013 | World Journal of Gastroenterology2013，19，31： | 4 |
| 2 | Trans-10, cis-12 conjugated linoleic acid decreases lipogenic rates and expression of genes involved in milk lipid synthesis in dairy cows显示文摘 | BAUMGARD L H MATITASHVILI E CORL B A | 2002 | Dairy Sci2002，85，： | 1 |
| 3 | CT evaluation of the colon:inflammatory disease显示文摘 | Horton KM Corl FM Fishman EK | 2000 | Radiographics2000，20，2： | 1 |
| 4 | CT of nonneoplastic diseases of the small bowel:spectrum of disease显示文摘 | Horton KM Corl FM Fishman EK | 1999 | J Comput Assist Tomogr1999，23，3： | 1 |
| 5 | Pathogenesis in acute aortic syndromes:aortic dissection,intramural hematoma,and penetrating atherosclerotic aortic ulcer显示文摘 | Macura KJ corl FM Fishman EK | 2003 | A JR2003，181，2： | 1 |
| 6 | Relationship ofbody condition score and oxidant stress to tumor nec- rosis factor expression in dairy cattle显示文摘 | O' Boyle N Corl C M Jeffery C | 2006 | Vet Immu- nol Immunopathol2006，113，34： | 1 |
| 7 | Pediatric skeletal trauma: use of multi planar reformatted and three -dimensional 64 -row multidetector CT in the emergency department 显示文摘 | Fayad LM Corl F Fishman EK | 2009 | Radiographies2009，29，1： | 1 |
| 8 | Validation of a Doppler guide wire for intravascular measurement of coronary artery flow velocity显示文摘 | CORL P D PAYNE H M | 1992 | Circulation1992，85，： | 1 |
| 9 | Imaging of renal trauma :a comprehensive review 显示文摘 | Kawashima A Sandier CM Corl FM | 2001 | Radiographics2001，21，3： | 1 |
| 10 | Transcriptional regulation of lipid synthesis in bovine mammary epithelial cells by sterol regulatory element binding protein-1显示文摘 | Ma L Corl B A | 2012 | J Dairy Sci2012，95，7： | 1 |
| 11 | Pathogenesis in acute aortic syndromes: aortic aneurysm leak and rupture and traumatic aortic transection 显示文摘 | MACURA J K CORL F M FISHMAN E K | 2003 | Am J Roentgenol2003，181，： | 1 |
| 12 | Tubular linear permanent magnet motors:an overall compari- son显示文摘 | Nicola Bianchi Silverio Bolognani Dario Dalla Corle | 2003 | IEEE Transactions on Industry Applieations2003，39，2： | 1 |
| 13 | Conjugated linoleic aoid is synthesized endogenously in lactating dairy cows by 9- desaturase显示文摘 | Griinari J M Corl B A Lacy S H | 2000 | J Nutr2000，130，9： | 1 |
| 14 | Effect of animal plasma proteins on intestinal damage and recovery of neonatal pigs infected with rotavirus显示文摘 | Corl B A Harrell R J Moon H K | 2007 | J Nutr Bio2007，18，： | 1 |
| 15 | Tumor transport physiology:Implications for imaging and imaging-guided therapy显示文摘 | Corl FM Franano FN | 2001 | AJR2001，177，4： | 1 |
| 16 | The Effect of Breed, Parity, and Stage of Lactation on Conjugated Linoleic Acid (CLA) in Milk Fat from Dairy Cows显示文摘 | KELSEY J A CORL B A COLLIER R J | 2003 | J Dairy Sci2003，86，： | 1 |
| 17 | Patterns of collateral pathways in extrahepatic portal hypertension as demonstrated by multideteetor row computed tomography and advanced image processing显示文摘 | Kamel IR Lawler LP Corl FM | 2004 | J Comput Assist Tomogr2004，28，4： | 1 |
| 18 | Validationof Doppler guide wire for intravascular measurement of coronaryartery flow velocity 显示文摘 | DOUCETTE J W CORL P D PAYNE H M | 1992 | Circulation1992，85，5： | 1 |
| 19 | A prospective study of the development of breast cancer in 16692 women with benign breast disease 显示文摘 | Corle DK | 1988 | Am J Epidemiol1988，128，： | 1 |
| 20 | Multi-detector row and volume-rendered CT of the normal and accessory flow pathways of the thoracic systemic and pulmonary veins显示文摘 | Lawler LP Corl FM Fishman EK | 2002 | Radiographics2002，，： | 1 |
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