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| 1 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 2 | A rational approach to catalytic enantionoseletive enolate alkylation using a structurally rigidified and defined chiral quaternary ammonium salt under phase transfer conditions 显示文摘 | COREY E J XU F NOE M C | 1997 | J Am Chem Soc1997，119，12： | 2 |
| 3 | Venous stasis ulceration:effectiveness of subfascial ligation显示文摘 | Johnson WC O Hara ET Corey C | 1985 | Arch Surg1985，120，： | 1 |
| 4 | Reduction of carbonyl compounds with chiral oxazaborolidine catalysts: a new paradigm for enantioselective catalysis and a powerful new synthetic method 显示文摘 | COREY E J HELAL C J | 1998 | Angew Chem Int Ed1998，37，15： | 1 |
| 5 | Valganciclovir for suppression of human herpesvirus 8 replication: a randomized, double blind, placebo controlled, crossover trial显示文摘 | Casper C Krantz E Corey L | 2008 | Infect Dis2008，198，1： | 1 |
| 6 | Interfirm Collabora- tion Networks: The Impact of Large-Scale Network Struc- ture on Finn Innovation显示文摘 | Melissa A Schilling Corey C Phelps | 2007 | Management Science2007，53，7： | 1 |
| 7 | Interfirm collaboration networks: The impact of small world connectivity on firm innovation显示文摘 | Schilling Melissa Corey C Phelps | 2007 | Management Science2007，53，： | 1 |
| 8 | Interfirm collaborationnetworics : The impact of large - scale network structure onfirm innovation 显示文摘 | Schilling Melissa A Phelps Corey C | 2007 | Management Science2007，53，7： | 1 |
| 9 | Enantioselective Mukaiyama-aldol and aldol-dihydropyrone annulation reactions catalyzed by a tryptophan-derived oxazaborolidine 显示文摘 | COREY E J CYWIN C L ROPER T D | 1992 | Tetrahedron Lett1992，33，46： | 1 |
| 10 | Phosphorus variation in surface runoff from agricultural lands as a function of land use显示文摘 | Wendt R C Corey R B | 1980 | J Environ Qual1980，9，1： | 1 |
| 11 | Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits : serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial显示文摘 | Jenkins D J A Kendall C W C Vuksan V Vidgen E Parker T Faulkner D Mehling C C Garsetti M Testolin G Cunnane S C Ryan bl A Corey P N | 2002 | The American Journal of Clinical Nutrition2002，75，5： | 1 |
| 12 | Sleeppromotion in hospitalized elder 显示文摘 | Corey L Nagel Megan B Markie Kathy C Richards | 2003 | Mcd Surg Nursing2003，，12： | 1 |
| 13 | QT interval is a heritable quantitative trait with evidence of linkage to chromosome 3 in a genome- wide linkage analysis: The Framingham Heart Study 显示文摘 | Newton-Cheh C Larson M G Corey D C | 2005 | Heart Rhythm2005，2，3： | 1 |
| 14 | Calculation of hydraulic conductivity : a further evaluation of some predictive methods 显示文摘 | GREEN R E COREY J C | 1971 | Soil Science Society of America Proceedings1971，35，1： | 1 |
| 15 | Interfirm Collabo- ration Networks: The impact of large- scale Network Structure on Firm Innovation 显示文摘 | Melissa A Schilling Corey C Phelps | 2007 | Management Science2007，，7： | 1 |
| 16 | Sleep promotion in hospitalized elder显示文摘 | Corey L Nagel Megan B Markie Kathy C Richards | 2003 | Med Surg Nursing2003，，12： | 1 |
| 17 | Interfirmcollaboration networks: The impact of large - scale network structure on firm innovation 显示文摘 | Melissa A Schilling Corey C Phelps | 2007 | Management Science2007，53，7： | 1 |
| 18 | Absent posterior tibia artery associated with idiopathic clubfoot 显示文摘 | Dobbs Mb Walton T Corey C | 2004 | J Bone Joint Surge(Am)2004，86，12： | 1 |
| 19 | Agricultural insur- ance as an environmental policy tool 显示文摘 | KEITH C TERRY H COREY M | 2003 | Journal of Agricul- tural and Applied Economics2003，35，2： | 1 |
| 20 | Characteristics of REE andother trace elements in response to successive and superimposedmetasomatism within a portion of the South Mountain Batholith,Nova Scotia, Canada 显示文摘 | COREY M C CHATTERJEE A K | 1990 | Chemical Geology1990，85，3： | 1 |
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