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| 1 | Assessment of stricturing Crohn's disease:Current clinicalpractice and future avenues显示文摘Crohn's disease(CD) is a chronic remittent idiopathic disease. Although the early phase of the disease is commonly characterized by inflammation-driven symptoms, such as diarrhea, the frequency of fibrostenotic complications in patients with CD increases over the long-term course of the disease. This review presents the current diagnostic options for assessing CD-associated strictures. In addition to the endoscopic evaluation of CD strictures, this review summarizes the currently available imaging modalities, including ultrasound and cross-sectional imaging techniques. In addition to stricture detection, differentiating between the primarily inflammatory strictures and the predominantly fibrotic ones is essential for selecting the appropriate treatment strategy(anti-inflammatory medical treatment vs endoscopical or surgical approaches). Therefore, recent imaging advances, such as contrast-enhanced ultrasound and ultrasound elastography, contribute to the development of noninvasive non-radiating imaging of CD-associated strictures. Finally, novel magnetic resonance imaging techniques, such as diffusion-weighted, motility and magnetization transfer imaging, as well as 18F-FDG PET/CT, molecular imaging approaches and biomarkers, are critically reviewed with regard to their potential role in assessing stricturing CD. | Dominik Bettenworth Tobias M Nowacki Friederike Cordes Boris Buerke Frank Lenze | 2016 | World Journal of Gastroenterology2016，22，3： | 4 |
| 2 | Detection and characterization of murine colitis and carcinogenesis by molecularly targeted contrast-enhanced ultrasound显示文摘AIM To study mucosal addressin cellular adhesion molecule-1(MAd CAM-1) and vascular endothelial growth factor(VEGF)-targeted contrast enhanced ultrasound(CEUS) for the assessment of murine colitis and carcinogenesis. METHODS C57BL/6 mice were challenged with 3% dextran sodium-sulfate(DSS) for three, six or nine days to study the development of acute colitis. Ultrasound was performed with and without the addition of unspecific contrast agents. MAd CAM-1-targeted contrast agent was used to detect and quantify MAd CAM-1 expression. Inflammatory driven colorectal azoxymethane(AOM)/DSS-induced carcinogenesis was examined on day 42 and 84 using VEGF-targeted contrast agent. Highly specific tissue echogenicity was quantified using specialized software. Sonographic findings were correlated to tissue staining, western blot analysis and immunohistochemistry to quantify the degree of inflammation and stage of carcinogenesis. RESULTS Native ultrasound detected increased general bowel wall thickening that correlated with more progressed and more severe DSS-colitis(healthy mice: 0.3 mm ± 0.03 vs six days DSS: 0.5 mm ± 0.2 vs nine days DSS: 0.6 mm ± 0.2, P < 0.05). Moreover, these sonographic findings correlated well with clinical parameters such as weight loss(r2 = 0.74) and histological damage(r2 = 0.86)(P < 0.01). In acute DSS-induced murine colitis, CEUS targeted against MAd CAM-1 detected and differentiated stages of mild, moderate and severe colitis via calculation of mean pixel contrast intensity in decibel(9.6 d B ± 1.6 vs 12.9 d B ± 1.4 vs 18 d B ± 3.33, P < 0.05). Employing the AOM/DSSinduced carcinogenesis model, tumor development was monitored by CEUS targeted against VEGF and detected a significantly increased echogenicity in tumors as compared to adjacent healthy mucosa(healthy mucosa, 1.6 d B ± 1.4 vs 42 d, 18.2 d B ± 3.3 vs 84 d, 18.6 d B ± 4.9, P < 0.01). Tissue echogenicity strongly correlated with histological analysis and immunohistochemistry findings(VEGF-positive cells in 10 high power fields of healthy mucosa: 1 ± 1.2 vs 42 d after DSS start: 2.4 ± 1.6 vs 84 d after DSS start: 3.5 ± 1.3, P < 0.01). CONCLUSION Molecularly targeted CEUS is a highly specific and noninvasive imaging modality, which characterizes murine intestinal inflammation and carcinogenesis in vivo. | Markus Brückner Jan Heidemann Tobias M Nowacki Friederike Cordes Jorg Stypmann Philipp Lenz Faekah Gohar Andreas Lügering Dominik Bettenworth | 2017 | World Journal of Gastroenterology2017，23，16： | 4 |
| 3 | Perspectives on the clinical development of mmunotherapy in prostate cancer显示文摘 | Lisa M Cordes James L Gulley Ravi A Madan | 2018 | Asian Journal of Andrology2018，20，3： | 2 |
| 4 | Relationships between serum adipokines ,insulin levels, and bone densitY in girls with anorexia nervosa显示文摘 | Misra M Miller KK Cord J | 2007 | J Clin Endocrinol Metab2007，92，： | 1 |
| 5 | Integrated Control of Root and Crown Rot in Sugar Beet: Combined Effects of Cultivar, Crop Rotation, and Soil Tillage显示文摘 | Cord Buhre Christian Kluth Klaus Barcky Bemward M?rl?nder and Mark Varrelmann | 2009 | Plant Disease2009，93，2： | 1 |
| 6 | Buliding resopnse to ex- cavation-induced stettlement 显示文摘 | Boscardin M D Cording E J | 1989 | Journal of Geotechnical Engineering1989，115，1： | 1 |
| 7 | The effect of high-dose angiotensin Ⅱ receptor blockade beyond maximal recommended doses in reducing urinary protein excretion显示文摘 | WEINBERG M S WEINBERG A J CORD R | 2001 | J Renin Angiotensin Aldosterone Syst2001，1，1： | 1 |
| 8 | The risk of permanent neurologic sequelae after continuous spinal anesthesia显示文摘 | Mollmann M Cord S Mayweg S | 1999 | Reg Anaesth Pain Med1999，24，3： | 1 |
| 9 | Superoxide dismutase:An en-zymic function for erythrocupein(Homocuprein)显示文摘 | Mc Cord J M Fridovich I | 1969 | JBiol Chem1969，244，： | 1 |
| 10 | Transcranial doppler ultrasound in internal carotid artery and middle cerebral artery disease 显示文摘 | Rosenkranz K Langer R Cordes M | 1992 | Neurosurg Rev1992，15，1： | 1 |
| 11 | Patterns ot burnout among managers and protessionals: A comparison ot models 显示文摘 | Cordes CL Dougherty TW Blum M | 1997 | J Organizational Behavior1997，18，6： | 1 |
| 12 | Ionizing radiation induces up-regulation of functional β1-integrin in human lung tumour cell lines in vitro显示文摘 | Cordes N Blaese M Meineke V | 2002 | Int J Radiat Biol2002，78，： | 1 |
| 13 | Automatic extraction of urban vegetation structures from high resolution imagery and digital elevation model显示文摘 | IOVAN C B CORD M D | 2007 | Urban Remote Sensing Joint Event2007，21，3： | 1 |
| 14 | A whole-genome RNAi screen identifies an 8@2 gene cluster that inhibits death receptor-mediated apoptosis 显示文摘 | Dompe N Rivers C S Li L Cordes S Schwickart M Punnoose E A | 2011 | Proc Natl Acad Sci USA2011，108，： | 1 |
| 15 | Stochastic ex- ploration and active learning for image retrieval 显示文摘 | CORD M COSSELIN P H PHILIPP-FOLIGUET S | 2007 | Image and Vi- sion Computing2007，25，1： | 1 |
| 16 | Aberrant default mode network in subjects with amnestic mild cognitive impairment using restingstate functional MRI显示文摘 | Jin M Pelak V S Cordes D | 2012 | Magn Reson Imaging2012，30，1： | 1 |
| 17 | Reducing Causal Ambiguity in Acquisition Integration:Intermediate Goals as Mediators of Integration Decisions and Acquisition Performance显示文摘 | Cording M Christmann P King D R | 2008 | Academy of Management Journal2008，51，： | 1 |
| 18 | Active learning methods for interactive image retrieval显示文摘 | Gosselin P H Cord M | 2008 | IEEE Transactions on Image Processing2008，17，7： | 1 |
| 19 | A Corporate Social Performance-Corporate Financial Performance Behavioral Model for Consumers 显示文摘 | Schuler D A Cording M | 2006 | Academy of Management Review2006，31，3： | 1 |
| 20 | A corporate social performance-corpo-rate financial performance behavioral model for consumers 显示文摘 | Schuler D Cording M | 2006 | Academy of Management Review2006，31，54： | 1 |
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