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| 1 | Cold-inducible RNA-binding protein activates splenic T cells during sepsis in a TLR4-dependent manner显示文摘Cold-inducible RNA-binding protein (CIRP) is a novel inflammatory mediator that stimulates the release of proinflammatory cytokines from macrophages in sepsis. Given the immune dysregulation that characterizes sepsis, the effect of CIRP on other immune cells is an area of increasing interest that has not yet been studied. In the present study, we hypothesized that extracellular CIRP promotes activation of T lymphocytes in the spleen during sepsis. We observed that mice subjected to sepsis by cecal ligation and puncture showed significantly higher expression of the early activation markers CD69 and CD25 at 20 h on CD4+ splenic T cells, and significantly higher CD69 expression on CD8+ splenic T cells compared with sham-operated controls. Furthermore, at 20 h after receiving intravenous injection of recombinant murine CIRP (rmCIRP, 5 mg/kg body weight (BW)) or PBS (vehicle), those mice receiving rmCIRP showed significantly increased expression of CD69 and CD25 on both CD4+ and CD8+ splenic T cells. This effect, however, was not seen in TLR4-deficient mice after rmCIRP injection. In addition, treatment with CIRP predisposed CD4+ T cells to a Th1 hyperinflammatory response profile, and influenced CD8+ T cells toward a cytotoxic profile. Taken together, our findings indicate that CIRP is a proinflammatory mediator that plays an important role in T-cell dysregulation during sepsis in a TLR4-dependent manner. | Alexandra C Bolognese Archna Sharma Weng-Lang Yang Jeffrey Nicastro Gene F Coppa Ping Wang | 2018 | Cellular & Molecular Immunology2018，15，1： | 4 |
| 2 | Conservative treatment of breast carcinoma in small breasts: new minimally invasive surgical technique显示文摘 | Sorrentino S Scappin S Coppa F | 2005 | Suppl Tumori2005，4，3： | 1 |
| 3 | Effects of holder pasteurization on human milk oligosaccharides显示文摘 | Bertino E Coppa GV Giuliani F | 2008 | Int J Immunopathol Pharmacol2008，21，2： | 1 |
| 4 | On-line high- performance liquid chromatography-fluorescence detection- electrospray ionization-mass spectrometry profiling of human milk oligosaccharides derivatized with 2-aminoacridone 显示文摘 | Galeotti F Coppa G V Zampini L | 2012 | Anal Biochem2012，430，1： | 1 |
| 5 | Gold Schottky contacts on oxygen plasma-treated,n-type ZnO(0001)显示文摘 | Coppa B J Davis R F Nemanich R J | | 0，，03： | 1 |
| 6 | Radiofrequency ablation and combined hepatic arterial ischemia for unresectable 3-6 cm hepatocellular carcinoma:A prospective study显示文摘 | Coppa J Garbagnati F Marchiano A | 2003 | Hepat2003，38，2： | 1 |
| 7 | Relation between bevacizumab dose intensity and high-grade glioma survival:a retrospective study in two large cohorts显示文摘Bevacizumab is one of the rare drugs that could improve high-grade glioma outcome after failure of chemoradiotherapy.However,to date,there is no biomarker predictive for efficacy of bevacizumab therapy in terms of survival improvement for patients with high- | Lorgis V Maura G Coppa G Hassani K Taillandier L Chauffert B Apetoh L Ladoire S Ghiringhelli F | 2012 | 中国神经肿瘤杂志2012，10，4： | 0 |
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