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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | 显示文摘 | Jahan M S Cooke D W Hults W L | 1990 | J Luminesc1990，47，： | 2 |
| 3 | Evidence-based clinical practice guideline for the prevention of ventilator-associated pneumonia显示文摘 | Dodek P Keenan S Cook D | 2004 | Ann Intern Med2004，141，4： | 1 |
| 4 | Short term evaluation of carbon coated and uncoated porous titanium implants clin显示文摘 | COOK S D HADDAD R J | 1989 | Clin Mater1989，4，： | 1 |
| 5 | Telephone nursecounseling for medication adherence in ulcerative colitis : apreliminary study 显示文摘 | Cook PF Emiliozzi S El-Hajj D | 2010 | Patient Educ Couns2010，81，2： | 1 |
| 6 | Improving the quality of reports of meta-analyses of randomised controlled trials : the QUOROM statement 显示文摘 | Moher D Cook DJ Eastwood S | 1999 | The Lancet1999，354，9193： | 1 |
| 7 | Acceleration of tibia and distal radius fracture healing in patients who smoke显示文摘 | Cook S D Ryaby J P McCabe J | 1997 | Clin Orthop Relat Res1997，337，： | 1 |
| 8 | Evidence-based clinical practice guideline for the prevention of ventilator-associated pneumonia显示文摘 | DODEK P KEENAN S COOK D | 2004 | Ann Intern Med2004，141，4： | 1 |
| 9 | The clinical signifcance of serum transferring receptor levels in sickle cell disease显示文摘 | Singhal A Cook J D Sikne B S | 1993 | Br J Haematol1993，84，： | 1 |
| 10 | Diagnostics for heteroscedasticity in regresion显示文摘 | Cook R D Weisberg S | 1982 | Biometrika1982，70，： | 1 |
| 11 | Atmospheric Corrosion of Different Steels in Marine, Rural and Industrial Environments 显示文摘 | Oh S J Cook D C Townsend H E | 1999 | Corrosion Science1999，41，3： | 1 |
| 12 | From Raw Materials to Cus- tomers: Supply Chain Management in the Service Industry 显示文摘 | JACK S COOK KATHY D AMIE F | 2001 | SAM Advanced Management Journal2001，66，4： | 1 |
| 13 | The deglacial history of surface and intermediate water of the Bering Sea显示文摘 | Cook M S Keigwin L D Sancetta C A | 2005 | Deep-Sea Research IT2005，52，： | 1 |
| 14 | Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients显示文摘 | Cook D J Walter S D Cook R J | | 0，，06： | 1 |
| 15 | Vegetative pro- duction of kenaf and canola under irrigation in central Califor- nia显示文摘 | BANUELOS G S BRYLA D R COOK C G | 2002 | Industrial Crops and Products2002，15，3： | 1 |
| 16 | Lipid modulation of Plasina mem- branebound ATPase 显示文摘 | Cooke D J Burden R S | 1990 | Plant Physiology1990，78，1： | 1 |
| 17 | Rapid sea level rise and Holocene climate in the Chukchi sea显示文摘 | Keigwin L D Donnell J P Cook M S | 2006 | Geology2006，34，10： | 1 |
| 18 | Characteristics and genesis of epithermal gold deposits 显示文摘 | Cooke D R Simmons S F | 2000 | Reviews in Economic Geology2000，13，2： | 1 |
| 19 | The effects of hardpan layers on the water chemistry, from the leaching of pyrrhotite-rich tailings material 显示文摘 | GILBERT S E COOKE D R HOLLINGS P | 2003 | Environmental Geology2003，44，： | 1 |
| 20 | Sequencing the genespaces of Medicago truncatula and Lotus japonicusl显示文摘 | Cannon S Sato S Kim D Cook D Town C Roe B Tabata S | 2005 | Plant Physiology2005，137，： | 1 |
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