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| 1 | Voxel-based magnetic resonance imaging investigation of poor and preserved clinical insight in people with schizophrenia显示文摘AIM To define regional grey-matter abnormalities in schizophrenia patients with poor insight(Insight-),relative to patients with preserved clinical insight(Insight+),and healthy controls.METHODS Forty stable schizophrenia outpatients(20 Insight-and 20 Insight+) and 20 healthy controls underwent whole brain magnetic resonance imaging(MRI).Insight in all patients was assessed using the Birchwood Insight Scale(BIS;a self-report measure).The two patient groups were preselected to match on most clinical and demographic parameters but,by design,they had markedly distinct BIS scores.Voxel-based morphometry employed in SPM8 was used to examine group differences in grey matter volumes across the whole brain.RESULTS The three participant groups were comparable in age [F(2,57) = 0.34,P = 0.71] and the patient groups did not differ in age at illness onset [t(38) = 0.87,P = 0.39].Insight-and Insight+ patient groups also did not differ in symptoms on the Positive and Negative Syndromes scale(PANSS):Positive symptoms [t(38) = 0.58,P = 0.57],negative symptoms [t(38) = 0.61,P = 0.55],general psychopathology [t(38) = 1.30,P = 0.20] and total PANSS scores [t(38) = 0.21,P = 0.84].The two patient groups,as expected,varied significantly in the level of BIS-assessed insight [t(38) = 12.11,P < 0.001].MRI results revealed lower fronto-temporal,parahippocampal,occipital and cerebellar grey matter volumes in Insightpatients,relative to Insight+ patients and healthy controls(for all clusters,family-wise error corrected P < 0.05).Insight+ patient and healthy controls did not differ significantly(P > 0.20) from each other.CONCLUSION Our findings demonstrate a clear association between poor clinical insight and smaller fronto-temporal,occipital and cerebellar grey matter volumes in stable long-term schizophrenia patients. | Adegboyega Sapara Dominic H Ffytche Michael A Cooke Steven CR Williams Veena Kumari | 2016 | World Journal of Psychiatry2016，6，3： | 3 |
| 2 | 相对于男性,女性进行冠状动脉造影产生的额外的心血管病风险与严重受损的冠状动脉血流储备,而非阻塞性疾病相关显示文摘与男性相比,女性的心血管病死亡率更高,但是阻塞性冠状动脉疾病(coronary artery disease,CAD)在女性中不太普遍。冠状动脉血流储备(coronary flow reserve,CFR)是大、小血管CAD和心肌缺血的综合测量指标,可识别出具有心血管病死亡风险的患者,但其在临床实践中不是常规测量的指标。该研究试图调查性别、CFR和血管造影CAD严重程度对不良心血管事件的影响。 | 刘莉 叶鹏 Taqueti VR Shaw LJ Cook NR Murthy VL Shah NR Foster CR Hainer J Blankstein R Dorbala S Di Carli MF | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 3 | Factors associated with elevated plateau pressure in patients with acute lung injury receiving lower tidal volume ventilation 显示文摘 | Prescott HC Brower RG Cooke CR | 2013 | Crit Care Med2013，41，3： | 1 |
| 4 | Subehandral bone changes in three different canine models of osteoarthritis 显示文摘 | Kuroki K Cook CR Cook JL | 2011 | Osteoarthritis and Cartilage2011，19，9： | 1 |
| 5 | Out-of-hospital charac- teristics and care of patients with severe sepsis: a cohort study 显示文摘 | Seymour CW Band RA Cooke CR | 2010 | J Crit Care2010，25，4： | 1 |
| 6 | Blood pressure and cerebral hemorrhage and ischemia in very low birth weight infants显示文摘 | Watkins AM West CR Cooke RW | 1989 | Early Hum Dev1989，19，2： | 1 |
| 7 | Altemation of platelet seronergic mechanism and monoan ine oxidas activity in premenstrual syndrome显示文摘 | Ashby CR Cart LA Cook CL | 1998 | Biol Psychiatry1998，24，： | 1 |
| 8 | The phospholipid scramblase PLSCR1 increases UV induced apoptosis primarily through the augmentation of the intrinsic apoptotic pathway and independent of direct phosphmTlation by protein kinase C delta显示文摘 | Bailey K Cook HW McMaster CR | 2005 | Biochim Bio- ohvs Acta2005，1733，23： | 1 |
| 9 | Predictors of hospital mortality in a population-based cohort of patients with acute lung injury 显示文摘 | Cooke CR Kahn JM Caldwell E | 2008 | Crit Care Med2008，36，5： | 1 |
| 10 | Variation in use of intensive care for adults with diabetic ketoacidosis显示文摘 | Gershengorn HB Iwashyna TJ Cooke CR | 2012 | Crit Care Med2012，40，7： | 1 |
| 11 | Effects of high-speed powertraining on muscle performance,function,and pain in older adultswith knee osteoarthritis:a pilot investigation显示文摘 | Sayers SP Gibson K Cook CR | | 0，，01： | 1 |
| 12 | A New Association of Sec- ond-Trimester Eehogenic Bowel and Metabolic Disease of the Neonate 显示文摘 | Lee M Cook CR Wilkins I | 2007 | J Ultrasound Med2007，26，8： | 1 |
| 13 | Cardiac surgery in the parturient显示文摘 | Chandrasekhar S Cook CR Collard CD | 2009 | AnesthAnalg2009，108，3： | 1 |
| 14 | Out -of- hospital character- istics and care of patients with severe sepsis: a cohort study显示文摘 | Seymour CW Band RA Cooke CR | 2010 | J Crit Care2010，25，4： | 1 |
| 15 | Isolation and characterization of arsenate-reducing bacteria from arsenic-contaminated sites in New Zealand显示文摘 | Anderson CR Cook GM | 2004 | Current Microbiology2004，48，5： | 1 |
| 16 | Cardiac surgery in the partu-rient显示文摘 | Chandrasekhar S Cook CR ColIard CD | 2009 | Anesth Analg2009，108，3： | 1 |
| 17 | The phospholipid scramblase PLSCR1 increases UV induced apop- tosis primarily through the augmenta- tion of the intrinsic apoptotic pathway and independent of direct phosphory- lation by protein kinase C 显示文摘 | BAILEY K COOK HW MCMASTER CR | 2005 | Biochim- icaet Biophysica Acta2005，1733，： | 1 |
| 18 | MRI versus ultrasonography to assess meniscal abnormalities in acute knees显示文摘 | Cook JL Cook CR Stannard JP | 2014 | J Knee Surg2014，，4： | 1 |
| 19 | Out-of-hospital characteristics and care of patients with severe sepsis: a cohort study 显示文摘 | Seymour CW Band RA Cooke CR | 2010 | J Crit Care2010，25，4： | 1 |
| 20 | Glomerular filtration rate and renal scintigraphy显示文摘 | Kerl ME Cook CR | 2005 | Clin Tech Small Anita Pract2005，20，： | 1 |
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