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15篇 您的检索式：作者名="Contu F"

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		题名	作者	年代	出处	被引量
	1	pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy.	Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira	2007	World Journal of Gastroenterology2007，13，11：	5
	2	HLA- G gene polymorphism in human placentas: possible association of ^*0105 allele with preeclampsia and miscarriage显示文摘	Moreau P Contu L Alba F	2008	Biol Reprod2008，79，3：	1
	3	HLA-G gene polymorphism in human placentas: possible association of G * 0106 allele with preeclampsia and miscarriage 显示文摘	Moreau P Contu L Alba F	2008	Biol Reprod2008，79，3：	1
	4	HLA-G gene polymorphism in human placentas:possible association of G*0106 allele with preeclampsia and miscarriage显示文摘	Moreau P Contu L Alba F	2008	Biol Reprod2008，79，3：	1
	5	HLA-G gene polymorphism in human placentas : possible association of G * 0106 allele with pre- eelampsia and miscarriage 显示文摘	Moreau P Contu L Alba F	2008	Biol Reprad2008，79，3：	1
	6	HLA-G gene polymorphism in human placentas:possible association of G*0106 allele with preeclampsia and miscarriage显示文摘	Moreau P Contu L Alba F	2008	Biol Reprod2008，79，：	1
	7	The use of cat- ionic fluoroprobes to characterize ionic pathways in organic coatings显示文摘	Taylor S R Contu F Santhanam R	2012	Prog Org Coat2012，73，：	1
	8	Corrosion behaviour of CoCrMoimplant alloy during fretting in bovine serum 显示文摘	Contu F Elesener B Bohni H	2005	Corros Sci2005，47，：	1
	9	HLA-G gene polymorphism in hu-man placentas:possible association of G * 0106 allele with preeclampsia and miscarriage 显示文摘	Moreau P Contu L Alba F	2008	Biol Reprod2008，79，3：	1
	10	HLA-G Gene Polymorphism in Human Placentas: Possible Association of G* 0106 Allele with Preeciampsia and Misearriage显示文摘	Moreau P Contu L Alba F	2008	tBiol Reprod2008，79，：	1
	11	Corrosion behaviour of CoCrMo implant alloy during fretting in bovine serum 显示文摘	Contu F Elsener B Bohni H	2005	Corrosion Science2005，47，8：	1
	12	Corrosion behaviour of CoCrMo implant alloy during fretting in bovine serum 显示文摘	Contu F Elsener B Bohni H	2005	Corrosion Science2005，47，8：	1
	13	HLA-G gene polymorphism in human placentas: possible association of G*0106 allele with preeclampsia and miscarriage 显示文摘	Moreau P Contu L Alba F	2008	Biol Reprod2008，79，3：	1
	14	Serum effect on the elec- trochemical behaviour of titanium, Ti6AI4V and Ti6AITNb alloys in sulphuric acid and sodium hydroxide显示文摘	CONTU F ELSENER B BOHNI H	2004	Corrosion Science2004，46，9：	1
	15	HLA-G gene polymorphism in human placentas: Possible association of G * 0106 allele with preeclampsia and miscarriage 显示文摘	Moreau P Contu L Alba F	2008	Biol Reprod2008，79，3：	1

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