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| 1 | Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study显示文摘 | Christopher D. Williams Joel Stengel Michael I. Asike Dawn M. Torres Janet Shaw Maricela Contreras Cristy L. Landt Stephen A. Harrison | 2011 | Gastroenterology2011，，1： | 20 |
| 2 | Wastewater Treatment for Removal of Recalcitrant Compounds:A Hybrid Process for Decolorization and Biodegradation of Dyes显示文摘While conventional wastewater treatments for urban effluents are fairly routine and have proved highly effective,industrial wastewater requires more complex and specific treatments.This paper provides a technological strategy for removal of recalcitrant contaminants based on a hybrid treatment system.The model effluent containing a binary mixture of synthetic dyes is treated by a combination of a preliminary physicochemical stage followed by a biological stage based on ligninolytic enzymes produced by Phanerochaete chrysosporium.This proposal includes biosorption onto peat as pretreatment,which decreases the volume and concentration to be treated in the biological reactor,thereby obtaining a completely decolorized effluent.The treated wastewater can therefore be reused in the dyeing baths with the consequent saving of water resources. | Carolyn Palma Andrea Carvajal Carlos Vasquez Elsa Contreras | 2011 | Chinese Journal of Chemical Engineering2011，19，4： | 12 |
| 3 | 乙型肝炎病毒导致的肝硬化伴肝癌患者血清中N糖组学改变显示文摘肝细胞癌(HCC)是最常见的肿瘤和最主要的死因之一,多发生于HBV和HCV感染导致的肝硬化患者,筛查肝硬化人群,早期诊断HCC可降低肿瘤的病死率。甲胎蛋白(AFP)是目前广泛应用的辅助诊断HCC的血清学指标,是对B超、CT等影像学诊断的有效补充。最近的荟萃分析表明,不同研究论文报道的AFP的灵敏度和特异度有很大的不同,这种现象不能完全用AFP的临界值不同解释。血清中的N糖蛋白主要由肝脏和B淋巴细胞合成,N糖成分的改变可反应肝脏或B淋巴细胞功能的改变,糖链的改变常常反应出机体的异常改变。糖组学在诊断领域的应用曾经因为缺少合适的分析技术而受限制,血清中N糖组学分析技术克服了这一屏障。本研究的目的是评价血清中N糖指纹图谱应用于乙型肝炎后肝硬化伴肝癌辅助诊断的意义。 | 刘学恩 Liesbeth Desmyter 高春芳 Wouter Laroy Sylviane Dewaele Valerie Vanhooren 王玲 庄辉 Nico Callewaert Claude Libert Roland Contreras 陈翠英 | 2008 | 中华肝脏病杂志2008，16，1： | 11 |
| 4 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 5 | Adipose tissue lipolysis and remodeling during the transition period of dairy cows显示文摘Elevated concentrations of plasma fatty acids in transition dairy cows are significantly associated with increased disease susceptibility and poor lactation performance. The main source of plasma fatty acids throughout the transition period is lipolysis from adipose tissue depots. During this time, plasma fatty acids serve as a source of calories mitigating the negative energy balance prompted by copious milk synthesis and limited dry matter intake.Past research has demonstrated that lipolysis in the adipose organ is a complex process that includes not only the activation of lipolytic pathways in response to neural, hormonal, or paracrine stimuli, but also important changes in the structure and cellular distribution of the tissue in a process known as adipose tissue remodeling. This process involves an inflammatory response with immune cell migration, proliferation of the cellular components of the stromal vascular fraction, and changes in the extracellular matrix. This review summarizes current knowledge on lipolysis in dairy cattle, expands on the new field of adipose tissue remodeling, and discusses how these biological processes affect transition cow health and productivity. | G.Andres Contreras Clarissa Strieder-Barboza William Raphael | 2017 | Journal of Animal Science and Biotechnology2017，8，4： | 8 |
| 6 | Slope reliability and back analysis of failure with geotechnical parameters estimated using Bayesian inference显示文摘A Bayesian approach is proposed for the inference of the geotechnical parameters used in slope design.The methodology involves the construction of posterior probability distributions that combine prior information on the parameter values with typical data from laboratory tests and site investigations used in design.The posterior distributions are often complex,multidimensional functions whose analysis requires the use of Markov chain Monte Carlo(MCMC)methods.These procedures are used to draw representative samples of the parameters investigated,providing information on their best estimate values,variability and correlations.The paper describes the methodology to define the posterior distributions of the input parameters for slope design and the use of these results for evaluation of the reliability of a slope with the first order reliability method(FORM).The reliability analysis corresponds to a forward stability analysis of the slope where the factor of safety(FS)is calculated with a surrogate model from the more likely values of the input parameters.The Bayesian model is also used to update the estimation of the input parameters based on the back analysis of slope failure.In this case,the condition FS?1 is treated as a data point that is compared with the model prediction of FS.The analysis requires a sufficient number of observations of failure to outbalance the effect of the initial input parameters.The parameters are updated according to their uncertainty,which is determined by the amount of data supporting them.The methodology is illustrated with an example of a rock slope characterised with a Hoek-Brown rock mass strength.The example is used to highlight the advantages of using Bayesian methods for the slope reliability analysis and to show the effects of data support on the results of the updating process from back analysis of failure. | Luis-Fernando Contreras Edwin T.Brown | 2019 | Journal of Rock Mechanics and Geotechnical Engineering2019，11，3： | 7 |
| 7 | An overview of plant-autochthonous microorganisms and fermented vegetable foods显示文摘Fermented plant-based foods and beverages constitute foods of high nutritional and functional value with appreciated health beneficial effects.They represent a natural and sustainable alternative to counteract the large wastage of vegetables and fruits due to their short shelf life.Usually,the use of controlled fermentation process using autochthonous microorganisms adapted to their vegetable matrix is preferred instead of traditionally spontaneous fermentation to designing fermented vegetable foods with the desirable sensory,technological,nutritional and functional properties.This review summarizes the autochthonous microorganisms selected as starters for the successful fermentation of vegetables and fruits.The main beneficial properties of autochthonous starters and fermented vegetable products with a focus on human health are revised. | Sebastian Torres Hernan Veron Luciana Contreras Maria I.Isla | 2020 | Food Science and Human Wellness2020，9，2： | 7 |
| 8 | A dual positional specific lipoxygenase functions in the generation of flavor compounds during climacteric ripening of apple显示文摘Lipoxygenase(LOX)is an important contributor to the formation of aroma-active C6 aldehydes in apple(Malus×domestica)fruit upon tissue disruption but little is known about its role in autonomously produced aroma volatiles from intact tissue.We explored the expression of 22 putative LOX genes in apple throughout ripening,but only six LOXs were expressed in a ripening-dependent manner.Recombinant LOX1:Md:1a,LOX1:Md:1c,LOX2:Md:2a and LOX2:Md:2b proteins showed 13/9-LOX,9-LOX,13/9-LOX and 13-LOX activity with linoleic acid,respectively.While products of LOX1:Md:1c and LOX2:Md:2b were S-configured,LOX1:Md:1a and LOX2:Md:2a formed 13(R)-hydroperoxides as major products.Site-directed mutagenesis of Gly567 to an alanine converted the dual positional specific LOX1:Md:1a to an enzyme with a high specificity for 9(S)-hydroperoxide formation.The high expression level of the corresponding MdLOX1a gene in stored apple fruit,the genetic association with a quantitative trait locus for fruit ester and the remarkable agreement in regio-and stereoselectivity of the LOX1:Md:1a reaction with the overall LOX activity found in mature apple fruits,suggest a major physiological function of LOX1:Md:1a during climacteric ripening of apples.While LOX1:Md:1c,LOX2:Md:2a and LOX2:Md:2b may contribute to aldehyde production in immature fruit upon cell disruption our results furnish additional evidence that LOX1:Md:1a probably regulates the availability of precursors for ester production in intact fruit tissue. | Doreen Schiller Carolina Contreras Jörg Vogt Frank Dunemann Bruno G Defilippi Randolph Beaudry Wilfried Schwab | 2015 | Horticulture Research2015，2，1： | 6 |
| 9 | Secreted protein acidic and rich in cysteine(SPARC)induces epithelial-mesenchymal transition,enhancing migration and invasion,and is associated with high Gleason score in prostate cancer显示文摘Secreted protein acidic and rich in cysteine(SPARC)is a matricellular protein highly expressed in bone tissue that acts as achemoattractant factor promoting the arrival of prostate cancer(PCa)cells to the bone marrow.However,the contribution of SPARCduring the early stages of tumor progression remains unclear.In this study,we show that SPARC is highly expressed in PCa tissueswith a higher Gleason score.Through stable knockdown and overexpression of SPARC in PC3 and LNCaP cells,respectively,here wedem on strate that en doge nous SPARC induces the epithelial-mesenchymal tran sition(EMT),decreasing E-cadheri n and cytokeratin18 and increasing N-cadheri n and vime ntin.Moreover,SPARC in duces the expression of EMT regulatory tran scription factors Snailfamily transcriptional repressor 1(Snail),Snail family transcriptional repressor 2(Slug),and zinc finger E-box binding homeobox 1(Zeb1).In addition,SPARC knockdown in PC3 cells decreases migration and invasion in vitro,without modifying cell proliferation.Our results indicate that SPARC might facilitate tumor progression by modifying the cellular phenotype in cancer cells. | Fernanda Lopez-Moncada Maria Jose Torres Enrique A Castellon Hector R Contreras | 2019 | Asian Journal of Andrology2019，21，6： | 5 |
| 10 | Predictive biomarkers for immune checkpoint blockade and opportunities for combination therapies显示文摘Immune checkpoint blockade therapies(ICBs)are a prominent breakthrough in cancer immunotherapy in recent years(named the 2013“Breakthrough of the Year”by the Science magazine).Thus far,FDA-approved ICBs primarily target immune checkpoints CTLA-4,PD-1,and PD-L1.Notwithstanding their impressive long-term therapeutic benefits,their efficacy is limited to a small subset of cancer patients.In addition,ICBs induce inadvertent immune-related adverse events(irAEs)and can be costly for long-term use.To overcome these limitations,two strategies are actively being pursued:identification of predictive biomarkers for clinical response to ICBs and multi-pronged combination therapies.Biomarkers will allow clinicians to practice a precision medicine approach in ICBs(biomarker-based patient selection)such as treating triple-negative breast cancer patients that exhibit PD-L1 staining of tumor-infiltrating immune cells in1%of the tumor area with nanoparticle albumin-bound(nab)epaclitaxel plus anti-PD-L1 and treating patients of MSI-H or MMR deficient unresectable or metastatic solid tumors with pembrolizumab(anti-PD-1).Importantly,the insights gained from these biomarker studies can guide rational combinatorial strategies such as CDK4/6 inhibitor/fractionated radiotherapy/HDACi in conjunction with ICBs to maximize therapeutic benefits.Further,with the rapid technological advents(e.g.,ATCT-Seq),we predict more reliable biomarkers will be identified,which in turn will inspire more promising combination therapies. | Hongxing Shen Eddy Shih-Hsin Yang Marty Conry John Fiveash Carlo Contreras James A.Bonner Lewis Zhichang Shi | 2019 | Genes & Diseases2019，6，3： | 5 |
| 11 | Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study显示文摘 | Christopher D. Williams Joel Stengel Michael I. Asike Dawn M. Torres Janet Shaw Maricela Contreras Cristy L. Landt Stephen A. Harrison | 2011 | Gastroenterology2011，，1： | 5 |
| 12 | The transcription factor ZEB1 promotes chemoresistance in prostate cancer cell lines显示文摘One of the factors promoting tumoral progress is the abnormal activation of the epithelial-mesenchymal transition(EMT)program which has been associated with chemoresistance in tumoral cells.The transcription factor zinc finger E-box-binding homeobox 1(ZEB1),a key EMT activator,has recently been related to docetaxel resistance,the main chemotherapeutic used in advanced prostate cancer treatment.The mechanisms involved in this protective effect are still unclear.In a previous work,we demonstrated that ZEB1 expression induced an EMT-like phenotype in prostate cancer cell lines.In this work,we used prostate cancer cell lines 22Rvl and DU145 to study the effect of ZEB1 modulation on docetaxel resistance and its possible mechanisms.The results showed that ZEB1 overexpression conferred to 22Rvl cell resistance to docetaxel while its silencing made DU145 cells more sensitive to it.Analysis of resistance markers showed no presenee of ATP-binding cassette subfamily B member 1(MDR1)and no changes in breast cancer resistance protein(BCRP)or ATP-binding cassette subfamily C member 10(MRP7).However,a correlation between ZEB1,multidrug resistance-associated protein 1(MRP1),and ATP-binding cassette subfamily C member 4(MRP4)expression was observed.MRP4 inhibition,using MK571,resensitized cells with ZEB1 overexpression to docetaxel treatment.In addition,modulation of ZEB1 and subsequent change in MRP4 expression correlated with a lower apoptotic response to docetaxel,characterized by lower B-cell lymphoma 2(Bcl2),high BCL2-associated X protein(Bax),and high active caspase 3 expression.The response to docetaxel in our model seems to be mediated mainly by activation of the apoptotic death program.Our results showed that modulation of MRP4 could be a mediator of ZEBl-related resistance to docetaxel in prostate cancer,making it a possible marker for chemotherapy response in patients who do not express MDR1. | Octavio Orellana-Serradell Daniela Herrera Enrique A Castellon Hector R Contreras | 2019 | Asian Journal of Andrology2019，21，5： | 5 |
| 13 | Bayesian data analysis to quantify the uncertainty of intact rock strength显示文摘One of the main difficulties in the geotechnical design process lies in dealing with uncertainty. Uncertainty is associated with natural variation of properties, and the imprecision and unpredictability caused by insufficient information on parameters or models. Probabilistic methods are normally used to quantify uncertainty. However, the frequentist approach commonly used for this purpose has some drawbacks.First, it lacks a formal framework for incorporating knowledge not represented by data. Second, it has limitations in providing a proper measure of the confidence of parameters inferred from data. The Bayesian approach offers a better framework for treating uncertainty in geotechnical design. The advantages of the Bayesian approach for uncertainty quantification are highlighted in this paper with the Bayesian regression analysis of laboratory test data to infer the intact rock strength parameters σ_(ci) and m_i used in the Hoek-Brown strength criterion. Two case examples are used to illustrate different aspects of the Bayesian methodology and to contrast the approach with a frequentist approach represented by the nonlinear least squares(NLLS) method. The paper discusses the use of a Student's t-distribution versus a normal distribution to handle outliers, the consideration of absolute versus relative residuals, and the comparison of quality of fitting results based on standard errors and Bayes factors. Uncertainty quantification with confidence and prediction intervals of the frequentist approach is compared with that based on scatter plots and bands of fitted envelopes of the Bayesian approach. Finally, the Bayesian method is extended to consider two improvements of the fitting analysis. The first is the case in which the Hoek-Brown parameter, a, is treated as a variable to improve the fitting in the triaxial region. The second is the incorporation of the uncertainty in the estimation of the direct tensile strength from Brazilian test results within the overall evaluation of the intact rock strength. | Luis Fernando Contreras Edwin T.Brown Marc Ruest | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，1： | 4 |
| 14 | The transcription factor ZEB1 promotes an aggressive phenotype in prostate cancer cell lines显示文摘 | Octavio Orellana-Serradell Daniela Herrera Enrique A Castellon Hector R Contreras | 2018 | Asian Journal of Andrology2018，20，3： | 4 |
| 15 | An NF90/NF110-mediated feedback amplification loop regulates dicer expression and controls ovarian carcinoma progression显示文摘 | Jerome Barbier Xin Chen Gabriel Sanchez Muyan Cai Marion Helsmoortel Takuma Higuchi Pierre Giraud Xavier Contreras Gangjun Yuan Zihao Feng Rima Nait-Saidi Olivier Deas Lisa Bluy Jean-Gabriel Judde Sylvie Rouquier William Ritchie Shuji Sakamoto Dan Xie Rosemary Kiernan | 2018 | Cell Research2018，28，5： | 3 |
| 16 | Functionalized CVD monolayer graphene for label-free impedimetric biosensing显示文摘在大区域 graphene 生长的最近的进展在不同区域导致了许多应用。在现在的学习,化学蒸汽扔了(CVD ) 在玻璃底层上支持的单层 graphene 为电气化学的 biosensing 应用作为电极材料被检验。我们由在酸的水的答案在 situ 准备的 carboxyphenyl 重氮基盐的电气化学的减小为 CVD 单层 graphene 的共有原子价 functionalization 报导灵巧的策略。修改 carboxyphenyl 的 graphene 用拉曼光谱学, X 光检查光电子光谱学(XPS ) ,和原子力量被描绘显微镜学(AFM ) ,以及电气化学的阻抗光谱学(EIS ) 。我们也证明 graphene 表面上的 grafted carboxyphenyl 组的数字能被扫描为 electrografting 使用了的周期的 voltammetry (CV ) 的数字控制。我们进一步在 grafted 的激活以后在 graphene 表面上基于 ovalbumin 抗体的固定介绍 immunosensor 的制造和描述经由 EDC/NHS 化学的羧基的组。在使表面不能调动的抗体和 ovalbumin 之间的绑定然后用 Faradaic EIS 被监视在[Fe (CN )< 潜水艇 class= “ a-plus-plus ” > 6 ] 3/4 答案。费用转移抵抗的百分比变化(R < 潜水艇 class= “ a-plus-plus ” > 在绑定以后的 ct ) 为从 1.0 pg 的 ovalbumin 集中展出了线性依赖? | Shimaa Eissa Gaston Contreras Jimenez Farzaneh Mahvash Abdeladim Guermoune Chaker Tlili Thomas Szkopek Mohammed Zourob Mohamed Siaj | 2015 | Nano Research2015，8，5： | 3 |
| 17 | Extended Preoperative Chemotherapy Does Not Improve Pathologic Response and Increases Postoperative Liver Insufficiency After Hepatic Resection for Colorectal Liver Metastases显示文摘 | Yoji Kishi MD Daria Zorzi MD Carlo M. Contreras MD Dipen M. Maru MD Scott Kopetz MD Dario Ribero MD Manuela Motta MD Nicoletta Ravarino MD Mauro Risio MD Steven A. Curley MD Eddie K. Abdalla MD Lorenzo Capussotti MD Jean-Nicolas Vauthey MD | 2010 | Annals of Surgical Oncology2010，，11： | 3 |
| 18 | Priorities and needs for research on urban interventions targeting vector-borne diseases: rapid review of scoping and systematic reviews显示文摘This paper highlights the critical importance of evidence on vector-borne diseases(VBD)prevention and control interventions in urban settings when assessing current and future needs,with a view to setting policy priorities that promote inclusive and equitable urban health services.Research should produce knowledge about policies and interventions that are intended to control and prevent VBDs at the population level and to reduce inequities.Such interventions include policy,program,and resource distribution approaches that address the social determinants of health and exert influence at organizational and system levels. | Clara Bermudez-Tamayo Olive Mukamana Mabel Carabali Lyda Osorio Florence Fournet Kounbobr Roch Dabiré Celina Turchi Marteli Adolfo Contreras Valéry Ridde | 2016 | Infectious Diseases of Poverty2016，5，1： | 3 |
| 19 | Treatment of chronic hepatitis C with direct-acting antivirals: The role of resistance显示文摘The use of direct-acting antivirals(DAAs) to treat chronic hepatitis C has resulted in a significant increase in rates of sustained viral response(around 90%-95%) as compared with the standard treatment of peginterferon/ribavirin. Despite this, however, the rates of therapeutic failure in daily clinical practice range from 10%-15%. Most of these cases are due to the presence of resistant viral variants, resulting from mutations produced by substitutions of amino acids in the viral target protein that reduce viral sensitivity to DAAs, thus limiting the efficacy of these drugs. The high genetic diversity of hepatitis C virus has resulted in the existence of resistance-associated variants(RAVs), sometimes even before starting treatment with DAAs, though generally at low levels. These preexisting RAVs do not appear to impact on the sustained viral response, whereas those that appear after DAA therapy could well be determinant in virological failure with future treatments. As well as the presence of RAVs, virological failure to treatment with DAAs is generally associated with other factors related with a poor response, such as the degree of fibrosis, the response to previous therapy, the viral load or the viral genotype. Nonetheless, viral breakthrough and relapse can still occur in the absence of detectable RAVs and after the use of highly effective DAAs, so that the true clinical impact of the presence of RAVs in therapeutic failure remains to be determined. | Miguel Jiménez-Pérez Rocío González-Grande Pilar Espana Contreras Isabel Pinazo Martínez Jesús de la Cruz Lombardo Raúl Olmedo Martín | 2016 | World Journal of Gastroenterology2016，22，29： | 3 |
| 20 | Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A Delphi technique-based consensus显示文摘AIM To propose several alternatives treatment of type 1 hepatorenal syndrome(HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal hypertension.METHODS A group of eleven gastroenterologists and nephrologists performed a structured analysis of available literature.Each expert was designated to review and answer a question.They generated draft statements for evaluation by all the experts.Additional input was obtained from medical community.In order to reach consensus,a modified three-round Delphi technique method was used.According to United States Preventive Services Task Force criteria,the quality of the evidence and level of recommendation supporting each statement was graded.RESULTS Nine questions were formulated.The available evidence was evaluated considering its quality,number of patients included in the studies and the consistency of its results.The generated questions were answered by the expert panel with a high level of agreement.Thus,a therapeutic algorithm was generated.The role of terlipressin and norepinephrine was confirmed as the pharmacologic treatment of choice.On the other hand the use of the combination of octreotide,midodrine and albumin without vasoconstrictors was discouraged.The role of several other options was also evaluated and the available evidence was explored and discussed.Liver transplantation is considered the definitive treatment for HRS-1.The present consensus is an important effort that intends to organize the available strategies based on the available evidence in the literature,the quality of the evidence and the benefits,adverse effects and availability of the therapeutic tools described.CONCLUSION Based on the available evidence the expert panel was able to discriminate the most appropriate therapeutic alternatives for the treatment of HRS-1. | Juan P Arab Juan C Claro Juan P Arancibia Jorge Contreras Fernando Gomez Cristian Munoz Leyla Nazal Eric Roessler Rodrigo Wolff Marco Arrese Carlos Benítez | 2016 | World Journal of Hepatology2016，8，25： | 3 |
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