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| 1 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 2 | 中国高放废物深地质处置研究显示文摘中国的放射性废物深地质处置研究始于1985年。在中国核工业总公司科技局下设有“高放废物深地质处置研究协调组”,负责研究项目的计划、协调和实施。协调组的组长单位是核工业北京地质研究院,参加单位有核工业北京工程设计研究院、中国原子能科学研究院和中国辐射防护研究院。中国已初步提出了高放废物深地质处置研究发展计划,其目标是于2040年左右建成一个国家地质处置库。中国将采用深地质处置方式处置高放废物,处置对象为玻璃固化块、超铀废物和部分乏燃料,处置库为竖井-坑道型,候选围岩为花岗岩。自1985年至今,中国在高放废物深地质处置方面取得了以下主要进展:(1)经过全国筛选、对比,已初步选出甘肃北山地区为中国高放废物处置库的最有利候选地区,该区地壳稳定,地处戈壁,人烟稀少,适宜建造处置库。对该区的评价正在进行;(2)已在北京郊区筛选出2个地下实验室场址:昌平县阳坊花岗岩和怀柔县石湖峪钼矿;(3)经全国筛选,已选出内蒙古高庙子膨润土矿床作为我国高放废物处置库缓冲/回填材料的首选矿床。(4)已初步获得一批核素在花岗岩和膨润土上的吸附、扩散数据,进行了核素迁移的初步方法学研究,研究发现辉锑矿对Tc有特殊的吸附作用,在缓冲材料中添加? | 王驹 徐国庆 uranium depsoits in China the contents of Pu 239 I 129 and Cl 36 have bee | 1998 | 水文地质工程地质1998，25，5： | 9 |
| 3 | 数量表征和韦伯—费希纳定律:应用及发展显示文摘数量表征是人类与动物最重要的认知能力之一。长期以来对于数量表征的模式存在争论,部分研究者认为人类表征数量的方式具有符号的、离散的性质;而另一些研究者则认为,数量表征同其他物理刺激的表征一样,具有类比的、连续的性质。该研究从心理物理学角度考察该问题,提出数量表征在行为表现上遵循韦伯—费希纳定律;不同发展阶段中个体的数量表征行为均遵循韦伯定律;在神经表达上表现为具有韦伯—费希纳定律特征的对数或线性模型。通过总结已有研究结果,该研究有力地支持数量表征具有连续的性质。这也为研究其它类似性质的高阶认知表征提供了一种新的研究思路。 | 孙霁 Alain Content 孙沛 | 2017 | 心理研究2017，10，5： | 7 |
| 4 | Solar cells based on CuIn(Se,S)2显示文摘 | WALTER T CONTENT A VELTHAUS K O | 1992 | Solar Energy Materials and Solar Cells1992，26，： | 1 |
| 5 | Immunogenicity and protective efficacy of a tuberculosis DNA vaccine 显示文摘 | Huygen K Content J Denis O | 1996 | Nat Med1996，2，8： | 1 |
| 6 | Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex显示文摘 | Lozes E Huygen K Content J | 1997 | Vaccine1997，15，8： | 1 |
| 7 | Replication and incompatibility properties of plasmid pE194 in Bacillus subtilis显示文摘 | Gryczan T J Hahn J Contente S | | 0，，： | 1 |
| 8 | The A TP binding cassette (ABC) transport systems of Mycobacterium tuberculosis显示文摘 | Braibant M Gilot P Content 1 | 2000 | FEMS Microbiol Rev2000，24，44： | 1 |
| 9 | Immunogenicity and protective efficacy of a tuberculosis DNA vaccine显示文摘 | HUYGEN K CONTENT J DENIS O | 1996 | Nat Med1996，2，8： | 1 |
| 10 | Immunogenicity and protective efficacy of a tuberculosis DNA vaccine显示文摘 | HUYGEN K CONTENT J DENIS O | 1996 | Nature Medicine1996，2，8： | 1 |
| 11 | A polymorphic microsatellite that mediates induction of PIG3 by p53 显示文摘 | Contente A Dittmer A Koch MC | 2002 | Nat Genet2002，30，3： | 1 |
| 12 | Protective efficacy of a DNA vaccine encoding antigen 85A from Mycobacterium bovis BCG against Buruli ulcer显示文摘 | A Tanghe J Content JP Van Vooren | | 0，，： | 1 |
| 13 | Immunogenicity and protective efficacy of a tuberculosis DNA vaccine显示文摘 | Huygen K Content J Denis O | 1996 | Nat Med1996，2，8： | 1 |
| 14 | A promoter that acquired p53 responsiveness during primate evolution 显示文摘 | Contente A Zischler H Einspanier A | 2003 | Cancer Res2003，63，8： | 1 |
| 15 | Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex显示文摘 | Lozes E Huygen K Content J | 1997 | Vaccine1997，15，8： | 1 |
| 16 | Immunogenicity and protective efficacy of a tuberculosis DNA vaccine显示文摘 | Huygen K Content J Denis O | 1996 | Nat Med1996，2，： | 1 |
| 17 | SPACE: the spectroscopic all-sky cosmic explorer显示文摘 | A. Cimatti M. Robberto C. Baugh S. V. W. Beckwith R. Content E. Daddi G. Lucia B. Garilli L. Guzzo G. Kauffmann M. Lehnert D. Maccagni A. Martínez-Sansigre F. Pasian I. N. Reid P. Rosati R. Salvaterra M. Stiavelli Y. Wang M. Zapatero Osorio M. Balcells M. | 2009 | Experimental Astronomy2009，，1： | 1 |
| 18 | Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex显示文摘 | Lozes E Huygen K Content J | 1997 | Vaccine1997，15，8： | 1 |
| 19 | Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex 显示文摘 | Lozes E 2 Huygen K Content J | 1997 | Vaccine1997，15，： | 1 |
| 20 | Stabilization mechanisms of soil organic matter:Implications for C-saturation of soils显示文摘 | SIX J CONTENT R T PAUL E A | 2002 | Plant and Soil2002，241，： | 1 |
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