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| 1 | Microdialysis in awake macaque monkeys for central nervous system pharmacokinetics显示文摘Background: The brain bioavailability of novel small molecules developed to address central nervous system disease is classically documented through ex vivo or in vivo analyses conducted in rodent models. Data acquired in rodent models are, however,not easily transferrable to human as the pharmacokinetic and pharmacodynamics profiles of the species are quite different.Methods: Using drugs selected for their differential transport across the blood-brain barrier, we here demonstrate the feasibility of brain microdialysis in normal vigil macaque monkey by measuring brain extracellular fluid bioavailability of carbamazepine, digoxin, oxycodone, and quinidine.Results: All drugs, but digoxin, were found in dialysate samples. Drugs that are substrate of P-glycoprotein show a difference of bioavailability or brain pharmacokinetic parameters between rodents and primates.Conclusion: Data suggest that brain microdialysis in vigil macaque monkey, the species of choice for classic pharmacokinetic/pharmacodynamics studies could help predicting human brain bioavailability of a small molecule depending on the protein involved in the efflux transport from the brain. | Thibaud Thiollier Caisheng Wu Gregory Porras Erwan Bezard Qin Li Jinlan Zhang Hugues Contamin | 2018 | Animal Models and Experimental Medicine2018，1，4： | 2 |
| 2 | Comparison of ultrasound effects in different reactors at 20 kHz显示文摘 | Faid 17 Contamine F Wilhelm A M | 1998 | Ultrasonics Sonochem1998，5，3： | 1 |
| 3 | Shear strengthe- ning of RC beams with textile reinforced concrete (TRC) plate 显示文摘 | Larbi A S Contamine R Ferrier E | 2010 | Construction and Building Materials2010，24，10： | 1 |
| 4 | Chemical reactions under ultrasound: discrimination of chemical and physical effects 显示文摘 | CONTAMINE F FAID F WIHELM A M | 1994 | Chem Eng Sci1994，49，24： | 1 |
| 5 | Experimental study of the ultrasound attenuation in chemical reactors显示文摘 | Romdhane M Gadri A Contamine F | 1997 | Ultrasonics Sonochm1997，4，3： | 1 |
| 6 | 显示文摘 | Maryer T Morris W A Versteeg K J Feasibility of using magnetic properties for assessment of particale associated contaminant transport | 1996 | Water Quality Research Journal Canada1996，31，： | 1 |
| 7 | Poly(I)-poly(C12U) but not ribavirin prevents death in a hamster model of Nipah virus infection显示文摘 | Contamin H Faure C | 2006 | Antimicrob Agents Chemother2006，50，5： | 1 |
| 8 | Scientific Opinion on the risks to public health related to the presence of perchlorate in food, in particular fruits and vegetables 显示文摘 | EFSA Panel on Contaminants in the Food Chain | 2014 | EFSA Journal2014，12，10： | 1 |
| 9 | Antibody prophylaxis and therapy against Nipah virus infection in hamsters显示文摘 | Contamin H Loth P | 2006 | J Virol2006，80，4： | 1 |
| 10 | Age-dependent carr iage of multiple Plasmodium falciparum merozoite surface antigen-2 alleles in a symptomatic malaria infections显示文摘 | Ntoumi F Contamin H Rogier C | 1995 | Am J Trop Med Hyg1995，52，： | 1 |
| 11 | Application of insulators in a contaminated environment显示文摘 | IEEE Working Group on Insulator Contamination | 1979 | IEEETransactions on Power Apparatus and Systems1979，98，5： | 1 |
| 12 | Power measurement in sonochemistry显示文摘 | RATOARINORO CONTAMINE F WILHELM A M | 1995 | Ultrasonics Sonochemistry1995，2，1： | 1 |
| 13 | TRC and hybrid solutions for repairing and/or strengthening reinforced concrete beams显示文摘 | A. Si Larbi R. Contamine P. Hamelin | 2012 | Engineering Structures2012，，： | 1 |
| 14 | TRC and hybrid solutions for repairing and/or strengthening reinforced con- crete beams显示文摘 | Larbi A S Contamine R Hamelin P | 2012 | Engineering Structures2012，45，12： | 1 |
| 15 | Power measurement in sonoehemistry显示文摘 | Contamine R F Wilhelm A M Berlan J | 1995 | Uhrason Senochem1995，2，2： | 1 |
| 16 | 显示文摘 | WANG Y LIANG L SHI J Study on the contamination of heavy metals and their correlations in mollusks collected from coastal sites along the Chinese Bohai Sea | 2005 | Environ Int2005，31，8： | 1 |
| 17 | L'Oriflamme de Saint- Denis aux XIVe et XVe siècles显示文摘 | Philippe Contamine | 1973 | Annales de l'' Est 251973，，： | 1 |
| 18 | 显示文摘 | Gantois I Ducatelle R Pasmans F contamination by Salmonella Enteritidis Reviews 2009 in press | 2009 | Mechanisms of egg FEMS Microbiology2009，，： | 1 |
| 19 | in Arctic marine food chains: identification, geographical distribution and temporal trends in polar bears 显示文摘 | Norstrom R J Simon M Organochlorine contaminants Muir D C G | 1988 | Environmental Science & Technology1988，22，9： | 1 |
| 20 | Identifying the contributing mechanisms of textile reinforced concrete (TRC) in the case of shear repairing damaged and reinforced concrete beams显示文摘 | R. Contamine A. Si Larbi P. Hamelin | 2013 | Engineering Structures2013，，： | 1 |
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