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| 1 | Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer显示文摘AIM: To assess the proteome of normal versus tumor tissue in squamous cell carcinoma of the esophagus (SCCE) in Iranian patients and compare our results with former reports by using proteomics. METHODS: Protein was extracted from normal and tumor tissues. Two dimensional electrophoresis was carried out and spots with differential expression were identified with mass spectrometry. RNA extraction and RT-PCR along with immunodetection were performed. RESULTS: Fourteen proteins were found whose expression levels differed in tumor compared to normal tissues. Mass spectrometric analysis resulted in the identification of β-tropomyosin (TMβ), myosin light chain 2 (and its isoform), myosin regulatory light chain 2, peroxyredoxin 2, annexinⅠand an unknown polypeptide as the down regulated polypeptides in tumor tissue. Heat shock protein 70 (HSP70), TPM4-ALK fusion oncoprotein 2, myosin light polypeptide 6, keratinⅠ, GH16431p and calreticulin were the up-regulated polypeptides found in tumor tissue. Several of these proteins, such as TMβ,HSP70, annexinⅠ, calreticulin, TPM4-ALK and isoforms of myosins, have been well recognized in tumorigenesis of esophageal or other types of cancers. CONCLUSION: Our study not only supports the involve- ment of some of the formerly reported proteins in SCCE but also introduces additional proteins found to be lost in SCCE, including TMβ. | Ferdous Rastgar Jazii Zahra Najafi Reza Malekzadeh Thomas P Conrads Abed Ali Ziaee Christian Abnet Mansour Yazdznbod Ali Asghar Karkhane Ghasem H Salekdeh | 2006 | World Journal of Gastroenterology2006，12，44： | 14 |
| 2 | Potential of phytoremediation for treatments of PAHs in soil at MGP sites显示文摘 | Pradhan S P Conrad J R Paterek J R | 1998 | J Soil Contam1998，7，： | 2 |
| 3 | Rayleigh-Taylor in- stability and convective thinning of mechanically thickened lithosphere: Effects of non-linear viscosity decreasing expo- nentially with depth and of horizontal shortening of the layer 显示文摘 | Molnar P Houseman G A Conrad C P | 1998 | Geophysical Journal International1998，133，： | 1 |
| 4 | Solid-phase crystalli-zation of amorphous silicon on ZnO:Al for thin-film solar cells显示文摘 | Becker C Conrad E Dogan P | 2009 | Solar Energy Mater Solar Cells2009，93，： | 1 |
| 5 | Neosporosisin cattle显示文摘 | Anderson M L Andrianarivo A G Conrad P A | 2000 | Animal Reproduction Science2000，60，： | 1 |
| 6 | Neospora-like encephalomyelitis in a calf: pathology, ultrastrueture, and immuno-reactivity显示文摘 | BARR B C CONRAD P A DUBEY J P | 1991 | J Vet Dia gn Invest1991，3，1： | 1 |
| 7 | Critical national infrastructure reliability modeling and analysis 显示文摘 | Conrad S H LeClaire R J O' Reilly G P | 2006 | Bell Labs Technical Journal2006，11，3： | 1 |
| 8 | Athletic footwear,leg stiffness,and running kinematics显示文摘 | Bishop M Fiolkowski P Conrad B Brunt D Horodyski M | | 0，，： | 1 |
| 9 | Colony (Grain) Size Reduction in Eutectic Pb-Sn Castings by Electroplusing 显示文摘 | Sprecher A F Conrad H | 1995 | Scripta Metallurgica et Materialia1995，32，6： | 1 |
| 10 | Methane emission from hypersaline microbial mats:lack of aerobic methane oxidation activity显示文摘 | Conrad R Frenzel P Cohen | 2006 | FEMS Microbiology Ecology2006，16，4： | 1 |
| 11 | Mechanism of inactivation of CDKN2 and MTS2 in non - small cell lung cancer and association with advanced stage 显示文摘 | NAKAGAWA K CONRAD N K WILLIAMS J P | 1995 | Oncogene1995，11，9： | 1 |
| 12 | Heterozygote and mutation detection by direct automated fluorescent DNA sequencing using a mutant Taq DNA polymerase显示文摘 | CHADWICK R B CONRAD M P MCGINNIS M D | 1996 | Biotechniques1996，20，4： | 1 |
| 13 | Prophylaxis against hepatitis B recurrence following liver transplantation using combination lamivudine and hepatitis B immunoglobulin显示文摘 | Markowitz JS Martin P Conrad JJ | 1998 | Hepatology1998，28，2： | 1 |
| 14 | Protection a- gainst RNA-induced liver damage by myeloid cells requires type I interferon and IL -1 receptor antagonist in mice显示文摘 | CONRAD E RESCH TK GOGESCH P | 2014 | Hepatology2014，59，4： | 1 |
| 15 | Role of miRNA and miRNA processing factors in development and disease显示文摘 | CONRAD R BARRIER M FORD L P | 2006 | Birth Defects Research Part C: Embryo Today: Reviews2006，78，2： | 1 |
| 16 | Electrical velocimetry demonstrates the increase in cardiac output and decrease in sys- temic vascular resistance accompanying cesarean delivery and oxy- tocin administration显示文摘 | Archer TL Conrad BE Suresh P | 2012 | J Clin Anesth2012，24，1： | 1 |
| 17 | Methods for fractionation,separation and profiling of proteins and peptides显示文摘 | ISSAQ H J CONRADS T P JANINI G M | 2002 | Electrophoresis2002，23，17： | 1 |
| 18 | Direct ampholyte-free liquid-phase isoelectric peptide focusing: application to the human serum proteome显示文摘 | XIAO Z CONRADS T P LUCAS D A | 2004 | Electrophoresis2004，25，1： | 1 |
| 19 | Distribution of Activator (Ac) throughout the maize genome for use in regional mutagenesis 显示文摘 | Kolkman J M Conrad L J Farmer P R | 2005 | Genetics2005，，169： | 1 |
| 20 | Colony(Grain) Size Reduction in Eutectic Pb-Sn Castings by Electroplusing 显示文摘 | Barnak J P Sprecher A F Conrad H | 1995 | Scripts Metallurgica et Materialia1995，32，6： | 1 |
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