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| 1 | Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer显示文摘AIM: To assess the proteome of normal versus tumor tissue in squamous cell carcinoma of the esophagus (SCCE) in Iranian patients and compare our results with former reports by using proteomics. METHODS: Protein was extracted from normal and tumor tissues. Two dimensional electrophoresis was carried out and spots with differential expression were identified with mass spectrometry. RNA extraction and RT-PCR along with immunodetection were performed. RESULTS: Fourteen proteins were found whose expression levels differed in tumor compared to normal tissues. Mass spectrometric analysis resulted in the identification of β-tropomyosin (TMβ), myosin light chain 2 (and its isoform), myosin regulatory light chain 2, peroxyredoxin 2, annexinⅠand an unknown polypeptide as the down regulated polypeptides in tumor tissue. Heat shock protein 70 (HSP70), TPM4-ALK fusion oncoprotein 2, myosin light polypeptide 6, keratinⅠ, GH16431p and calreticulin were the up-regulated polypeptides found in tumor tissue. Several of these proteins, such as TMβ,HSP70, annexinⅠ, calreticulin, TPM4-ALK and isoforms of myosins, have been well recognized in tumorigenesis of esophageal or other types of cancers. CONCLUSION: Our study not only supports the involve- ment of some of the formerly reported proteins in SCCE but also introduces additional proteins found to be lost in SCCE, including TMβ. | Ferdous Rastgar Jazii Zahra Najafi Reza Malekzadeh Thomas P Conrads Abed Ali Ziaee Christian Abnet Mansour Yazdznbod Ali Asghar Karkhane Ghasem H Salekdeh | 2006 | World Journal of Gastroenterology2006，12，44： | 14 |
| 2 | 显示文摘 | Wong A Luth H J Decether Conrad W | 2001 | Brain Res2001，920，12： | 1 |
| 3 | Multipotent mesenchymal stem cells acquire a lymphendothelial phenotype and enhance lymphatic re- generation in vivo 显示文摘 | Conrad C Niess H Huss R | 2009 | Circulation2009，119，2： | 1 |
| 4 | Vitamin E and selenium for reproduction of the dairy cow < sup> 1 ,2 < / sup>显示文摘 | HarrisonJ H Hancock D D Conrad H R | 1984 | Journal of Dairy Science1984，67，1： | 1 |
| 5 | Extracorporeal Life Support Registry Report2004显示文摘 | Conrad SA Rycus PT Dalton H | 2005 | ASAIO J2005，51，： | 1 |
| 6 | Unbalance compensation using generalized notch filters in the multivariable feedback of magnetic bearing显示文摘 | Raoul H Conrad G Rene L | 1996 | IEEE Transactions on Control Systems Technology1996，4，： | 1 |
| 7 | External electric field applied during solution heat treatment of the Al-Mg-Si alloy AA6022显示文摘 | JUNG K CONRAD H | 2004 | Journal of Materials Science2004，39，21： | 1 |
| 8 | Influence of an Electric or Magnetic Field on the Liquid-Solid Transformation in Materials and on the Microstructure of the Solid 显示文摘 | | 2000 | Materials Science and Engineering2000，287，2： | 1 |
| 9 | Specific inflammatory cytokines regulate the expression of human monocyte 15-lipexygenase 显示文摘 | Conrad DJ KUhn H Mulkins M | 1992 | Proc Natl Acad Sci U S A1992，89，1： | 1 |
| 10 | Neogenin-RGMa Signaling at the Growth Cone is BMP-independent and Involves RhoA,Rock and PKC显示文摘 | CONRAD S GENTH H HOFMANN F | 2007 | J Biol Chem(S0021--9258)2007，，： | 1 |
| 11 | Effect of soil characteristics on sequential reduction and methane production in sixteen rice paddy soils from China, the Philippines and Italy 显示文摘 | Yao H Conrad R Wassmann R | 1999 | Biogeochemistry1999，47，3： | 1 |
| 12 | Advanced glycation end products co-localize with inducible nitric oxide synthase in Alzheimer's disease 显示文摘 | Wong A Luth H J Deut her Conrad W | 2001 | Brain Res2001，920，12： | 1 |
| 13 | Critical national infrastructure reliability modeling and analysis 显示文摘 | Conrad S H LeClaire R J O' Reilly G P | 2006 | Bell Labs Technical Journal2006，11，3： | 1 |
| 14 | Colony (Grain) Size Reduction in Eutectic Pb-Sn Castings by Electroplusing 显示文摘 | Sprecher A F Conrad H | 1995 | Scripta Metallurgica et Materialia1995，32，6： | 1 |
| 15 | Effect of electric current pulses on the recrystallization of copper 显示文摘 | Conrad H NASSER K SARDARI M | 1983 | Scripta metallurgica1983，17，3： | 1 |
| 16 | Influence of an electric or magnetic field on the liquid-solid transformation in materials and on the microstructure of the solid 显示文摘 | Conrad H | 2000 | Materials Science and Engineering A2000，287，2： | 1 |
| 17 | Effect of an electric field on the plastic defoination kinetics of electrodeposited Cu at low and intermediate temperatures显示文摘 | Conrad H Yang D | 2002 | Acta Materialia2002，50，11： | 1 |
| 18 | SELEDO: a 5-year long term trial on the effect of selegine in early Parkinsonian patients treated with levodopa显示文摘 | Przuntek H Conrad B Dichgans M | 1999 | Eur J Neurol1999，6，2： | 1 |
| 19 | Plasma generation and plasma sources显示文摘 | Conrads H Schmidt M | 2000 | Plasma Sources Sci Technol2000，9，4： | 1 |
| 20 | Balance and Aging显示文摘 | Conrad H R | 1993 | Ann Neurol1993，，5： | 1 |
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