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	题名	作者	年代	出处	被引量
1	Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team.	Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel	2014	World Journal of Gastroenterology2014，20，42：	5
2	Main outcomes from in situ thermo-hydro-mechanical experiments programme to demonstrate feasibility of radioactive high-level waste disposal in the Callovo-Oxfordian claystone显示文摘In the context of radioactive waste disposal,an underground research laboratory(URL)is a facility in which experiments are conducted to demonstrate the feasibility of constructing and operating a radioactive waste disposal facility within a geological formation.The Meuse/Haute-Marne URL is a sitespecific facility planned to study the feasibility of a radioactive waste disposal in the Callovo-Oxfordian(COx)claystone.The thermo-hydro-mechanical(THM)behaviour of the host rock is significant for the design of the underground nuclear waste disposal facility and for its long-term safety.The French National Radioactive Waste Management Agency(Andra)has begun a research programme aiming to demonstrate the relevancy of the French high-level waste(HLW)concept.This paper presents the programme implemented from small-scale(small diameter)boreholes to full-scale demonstration experiments to study the THM effects of the thermal transient on the COx claystone and the strategy implemented in this new programme to demonstrate and optimise current disposal facility components for HLW.It shows that the French high-level waste concept is feasible and working in the COx claystone.It also exhibits that,as for other plastic clay or claystone,heating-induced pore pressure increases and that the THM behaviour is anisotropic.	G. Armand F. Bumbieler N. Conil R. de la Vaissière J.-M. Bosgiraud M.-N. Vu	2017	Journal of Rock Mechanics and Geotechnical Engineering2017，9，3：	4
3	Radiotherapy for in situ extramammary Paget disease of the vulva显示文摘	Moreno-Arias GA Conill C Sola-Casas MA	2003	J Dermatolog Treat2003，14，：	1
4	Risk of emergence of Pseudononas aeruginosa resistance to betalaclam antibiotics in intensive care units 显示文摘	Georges R Conil JM Dubouix A	2006	Crit Care Med2006，34，6：	1
5	Comparison of positron emission tomography (PET)and computed tomo-graphy(CT) for better target volume deft nition in radiation therapy planning 显示文摘	Vila A S6nchez-Reyes A Conill C	2010	Clin Transl Oncol2010，12，5：	1
6	Population pharmacokinetics of ceftazidime in intensive care unit patients:influence of glomerular filtration rate,mechanical ventilation,and reason for admission显示文摘	Georges B Conil JM Seguin T	2009	Antimicrob Agents Chemother2009，5300，：	1
7	Retrospective analysis of multidrug-resistant Acinetobacter baumannii strains isolated during a 4-year period in a university hospital 显示文摘	Fillaux J Dubouix A Conil JM	2006	Infect Control Hosp Epidemiol2006，27，7：	1
8	Incidence of radiation-induced leukoencephalopathy after whole brain radiotherapy in patients with brain metastases显示文摘	Conill C Berenguer J Vargas M	2007	Clin Transl Oncol2007，9，9：	1
9	显示文摘	Kuntz E G	1995	J Organomet Chem1995，502，：	1
10	Risk of emergence of pseudomonas aeruginosa resistance to β-lactam antibiotics in intensive care unit显示文摘	Georges B Conil JM Dubouix A	2006	Crit Care Med2006，34，：	1
11	Ceftazidime dosage recommen-dations in bum patients : from a population pharmacokinetic approachto clinical practice via Monte Carlo simulations 显示文摘	Conil JM Georges B Ravat F	2013	Clin Ther2013，35，10：	1
12	Poroplastic damage model for claystones显示文摘	CONIL N DJERAN-MAIGER I CABRILLAR R	2004	Applied Clay Science2004，26，1234：	1
13	Radiotherapy for genital extramammary Paget's disease in situ 显示文摘	Moreno-Arias GA Conill C Castells-Mas A	2001	Dermatol Surg2001，27，6：	1
14	Contribution of Magnetic Resonance Imaging in the Early Diagnosis of Epidural Metastasis显示文摘	Verger E Conill C Vila A	1992	Med Clin1992，99，9：	1
15	Role of calcium ions in the mechanism of action of a lignosulphonate used to modify the wettability of plastics for their separation by flotation显示文摘	GUERN C L CONIL P HOUOT R	2000	Minerals Engineering2000，13，1：	1
16	Effects of injection position and transponder size on the performances of passive injectable transponders used for the electronic identification of cattle 显示文摘	Conill C G Caja R Nehring	2000	J Anim Sci2000，，78：	1
17	The use of passive injectable transponders in fattening lambs from birth to slaughter:Effects of injecfon position, age and breed 显示文摘	Conill C G Caja R Nehring	2002	J Anim Sci2002，80，：	1
18	Executive summary:ACC/AHA guidelines for implantation of cardiac pacemakers and antiarrhythmia devices显示文摘	Gregoratos G Cheitlin MD Conill A	1998	Circulation1998，97，13：	1
19	ACC/AHA guidelines for implantation of cardiac pacemakers and antiarrhythmia devices: executive summary-a report of the American college of cardiology/American heart association task force on practice guidelines (committee on pacemaker implantation)显示文摘	Gregoratos G Cheitlin MD Conill A	1998	Circulation1998，97，：	1
20	Poroplastic damage model for claystones 显示文摘	CONIL N DJERAN - MAIGRE I CABRILLAC R SU K	2004	Applied Clay Science2004，26，14：	1

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