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32篇 您的检索式：作者名="Conigrave"

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	题名	作者	年代	出处	被引量
1	向在人的察觉到钙的受体的 allosteric 药的结构的理解显示文摘allosterically 指向人的察觉到钙的受体(CaSR ) 的药有实质的治疗学的潜力,但是当前被限制。给 CaSR 的高分辨率的结构的缺席,我们把 mutagenesis 与一条新奇分析途径并且开发 “ 的分子的建模相结合; enriched”为在 Ca ²⁺_{在 CaSRs 7 transmembrane (7TM ) 以内的 o} 和 allosteric 调节的人领域。修改多重有约束力的地点以适应在结构上的一个扩大的洞多样的 ligands 被识别。Phenylalkylamines 绑在与通常认为的 Ca ²⁺_o-binding 地点并且向一个细胞外的门厅延长。相反,在结构上和 pharmacologically 不同的 AC-265347 在 7TM 领域以内更深绑。而且,不同氨基酸网络被发现调停由不同调节的人的 cooperativity。这些调查结果可以与不同、潜在地偏导小径的药理学效果便于 allosteric 调节的人的合理设计。	Katie Leach Karen J Gregory Irina Kufareva Elham Khajehali Anna E Cook Ruben Abagyan Arthur D Conigrave Patrick M Sexton Arthur Christopoulos	2016	Cell Research2016，26，5：	2
2	L-amino acid sensing by the extracellular Ca2+-sensing receptor 显示文摘	Conigrave DA Quinn JS Brown ME	2000	PNAS2000，97，9：	1
3	Combiningcarbohydrate-deficient transferrin and gamma-glutamyltransferase to increase diagnostic accuracy forproblem drinking显示文摘	Chen J Conigrave KM Macaskill P	2003	Alcohol Alcohol2003，38，6：	1
4	A prospective study of drinking patterns in relation to risk of type 2 diabe- tes among men显示文摘	Katherine M Conigrave B Frank H	2001	Diabets2001，50，：	1
5	Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men显示文摘	Mukamal KJ Conigrave KM Mittleman MA	2003	N Engl J Med2003，348，2：	1
6	Regulation of cellular signal transduction pathways by the extracellular calcium-sensing receptor显示文摘	BRENNAN S C CONIGRAVE A D	2009	Curr Pharm Biotechnol2009，10，3：	1
7	Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men显示文摘	Mukamal KJ Conigrave KM Mittleman MA	2003	N Engl J Med2003，348，2：	1
8	A prospective study of drinking patterns in relation to risk of type 2 diabetes among men显示文摘	Conigrave KM Hu BF Camargo CA Jr	2001	Diabetes2001，50，：	1
9	Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men 显示文摘	Mukamal KJ Conigrave KM Mittleman MA	2003	N Engl J Med2003，348，2：	1
10	Predictive capacity of the AUDIT questionnaire for alcohol-related harm显示文摘	Conigrave K M	1995	Addiction1995，，90：	1
11	Calcium-sensing receptor (CaSR): pharmacological properties and signaling pathways显示文摘	Conigrave A D Ward D T	2013	Best Pract Res Clin Endocrinol Metab2013，27，3：	1
12	The AUDIT questionnaire:choosing a cutoff score显示文摘	Conigrave K M Hall W D	1995	Addication1995，，90：	1
13	A Prospective Study of Drinking Patterns in Relation to Risk of Type 2 Diabetes Among Men显示文摘	KATHERINE M CONIGRAVE B FRANK Hu	2001	Diabet2001，50，：	1
14	L-amino acid-sensing by calci-um-sensing receptors: implications for GI physiology显示文摘	Conigrave A D Brown E M	2006	AmJ Physiol Gastrointest Liver Physiol2006，291，5：	1
15	Alcohol use in China 显示文摘	Cochrane J Chen H Conigrave KM	2003	Alcohol Alcohol2003，38，6：	1
16	Why are alcohol - related emergency department presentations under - detected? An exploratory study using nursing triage text显示文摘	Indig D Copeland J Conigrave KM	2008	Drug Alcohol Rev2008，29，：	1
17	Cooperative multi - modal sensing and therapeutic implications of the extracellular Ca^2+ - sensing receptor 显示文摘	Conigrave D Quinn S J Brown EM	2000	Trends Pharmacol Sci2000，21，10：	1
18	L-aminoacid sensing by the calcium-sensing receptor: a general mech-anism for coupling protein and calcium metabolism显示文摘	Conigrave A D Franks A H Brown E M	2002	Eur JClin Nutri2002，56，11：	1
19	L-amino acid sensing by the calcium-sensing receptor:a general mechanism for coupling protein and calcium metabolism?显示文摘	Conigrave AD Franks AH Brown EM	2002	Eur J Clin Nutri2002，56，11：	1
20	Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men显示文摘	Mukamal KJ Conigrave KM Mittleman MA	2003	N Engl J Med2003，348，2：	1

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