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| 1 | Self-supporting nanoporous gold-palladium overlayer bifunctional catalysts toward oxygen reduction and evolution reactions显示文摘氧减小反应(ORR ) 和氧进化反应(OER ) 是为能量变换 / 存储系统的关键过程,例如燃料房间,金属空气电池,并且水切开。然而,两反应被他们的懒惰动力学严重地限制,因此要求高度活跃、划算、持久的 electrocatalysts。此处,我们通过驾驶 dealloying 的 nanoporous 黄金(NPG ) 的表面 nanoengineering 开发新奇 bifunctional nanocatalysts。Pd overlayers 被取向附生的 layer-by-layer 生长精确扔到 NPG 系带表面上。更重要地,获得的 NPG-Pd overlayer nanocatalysts 展览显著地在碱的媒介向 ORR 和 OER 提高了 electrocatalytic 活动,对 stateof- 艺术 Pt/C 催化剂的 benchmarked。改进 electrocatalytic 性能被 NPG,从 Pd overlayers 的精确控制的提高的 Pd 利用效率,和变化的唯一的三维的 nanoarchitecture 在电子结构文饰,作为由密度揭示了功能的理论计算。 | Yan Wang Wei Huang Conghui Si Jie Zhang Xuejiao Yan Chuanhong Jin Yi Ding Zhonghua Zhang | 2016 | Nano Research2016，9，12： | 3 |
| 2 | The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells显示文摘Pancreatic adenocarcinoma(PAAD) is one of the most lethal malignancies. Although gemcitabine(GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C(Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not been investigated since it was isolated. Our research is the first to indicate that Sec C is a broad-spectrum anticancer agent and could exhibit potently similar anticancer activity both in GEM-resistant and GEM-sensitive PAAD cells. Interestingly, Sec C exerted a rapid growth-inhibiting effect(80% death at 6 h), which might be beneficial for patients who need rapid tumor shrinkage before surgery. Liquid chromatography/mass spectrometry and N-acetyl-L-cysteine(NAC) reverse assays show that Sec C sulfates cysteines to disrupt disulfide-bonds formation in endoplasmic reticulum(ER) proteins to cause protein misfolding, leading to ER stress and disorder of lipid biosynthesis. Microarray data and subsequent assays show that ER stress-mediated ER-associated degradation(ERAD) ubiquitinates anddownregulates YAP to enhance ER stress via destruction complex(YAP-Axin-GSK-βTr CP), which also elucidates a unique degrading style for YAP. Potent anticancer activity in GEM-resistant cells and low toxicity make Sec C a promising anti-PAAD candidate. | Junxia Wang Minghua Chen Mengyan Wang Wenxia Zhao Conghui Zhang Xiujun Liu Meilian Cai Yuhan Qiu Tianshu Zhang Huimin Zhou Wuli Zhao Shuyi Si Rongguang Shao | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 2 |
| 3 | Multicomponent platinum-free nanoporous Pd-based alloy as an active and methanol-tolerant electrocatalyst for the oxygen reduction reaction显示文摘高效的氧减小反应(ORR ) 的开发催化剂是关键的改进质子交换膜燃料房间。此处, multicomponent nanoporous PdCuTiAl (np-PdCuTiAl ) electrocatalyst 被灵巧的一步舞 dealloying 策略综合了。np-PdCuTiAl 催化剂展出贯穿的三维的 bicontinuous 有 ~ 的极其细小的长度规模的系带 / 隧道结构 3.7 nm。np PdCuTiAl 的一半波浪潜力是 0.873 V 对 RHE,比那些更积极 PdC (0.756 V 对 RHE ) 和 PtC (0.864 V 对 RHE ) 催化剂。np-PdCuTiAl 合金与类似的 Tafel 斜坡显示出一条 4 电子反应小径到 PtC。显著地,一半波浪潜力面对甲醇为 np-PdCuTiAl 显示出仅仅 12 mV 的否定移动,并且这否定移动是比 PdC (50 mV ) 和 PtC (165 mV ) 的那些低得多的催化剂。np-PdCuTiAl 的提高的 ORR 活动进一步通过密度被文饰功能的理论计算。 | Xiaoting Chen Conghui Si Ying Wang Yi Ding Zhonghua Zhang | 2016 | Nano Research2016，9，6： | 2 |
| 4 | Functional analysis of flavanone 3-hydroxylase(F3H)from Dendrobium officinale,which confers abiotic stress tolerance显示文摘Flavonoids are important bioactive components in Dendrobium officinale,a medicinal orchid.They are involved in many biological activities,including protecting plants against biotic and abiotic stresses.Research on the key genes related to flavonoid biosynthesis in D.officinale is limited.In this study,one of the key flavonoid biosynthesis genes,flavanone 3-hydroxylase(F3H),was characterized from D.officinale.The open reading frame of DoF3H was 1134 bp long and it encoded a 377-amino acid protein.The DoF3H protein showed considerably high homology with F3H proteins from other plant species and shared a common evolutionary ancestor with other F3Hs.DoF3H transcripts were detected in different organs of adult plants and mainly accumulated in flowers,followed by roots,stems and leaves,a pattern that was similar to the content of flavonoids.Recombinant DoF3H protein,which was localized in the cytosol,could convert naringenin to dihydrokaempferol.The mRNA levels of DoF3H were significantly induced by salt and cold stresses.Furthermore,the heterologous expression of DoF3H in Escherichia coli conferred it higher tolerance to salt and cold stresses.These results provide insight into the molecular function of DoF3H in the biosynthesis of flavonoids,and provide a new application for improvement of abiotic tolerance in D.officinale. | Can Si Wei Dong Jaime A.Teixeira da Silva Chunmei He Zhenming Yu Mingze Zhang Lei Huang Conghui Zhao Danqi Zeng Chuanmao Li Shengxiang Qiu Jun Duan | 2023 | Horticultural Plant Journal2023，9，2： | 1 |
| 5 | Tungsten diselenide nanoplates as advanced lithium/ sodium ion electrode materials with different storage mechanisms显示文摘转变金属 dichalcogenides (TMD ) 由于他们的像三明治的分层的结构作为 lithium/ 钠离子电极材料展出巨大的潜力。优化他们的 lithium/sodium-storage 表演,二个问题应该被处理:根本上理解发生在 TMD 电极和发展中的新奇 TMD 的化学反应。在这研究, WSe 2 六角形的 nanoplates 作为 lithium/sodium-ion 被综合电池(解放 / 亲族) 电极材料。为解放, WSe 2-nanoplate 电极完成了一个稳定的可逆能力和高率能力,以及多达 1,500 的 ultralong 周期生活在 1,000 妈敢楬杮瀠潲散畤敲 ? 牯猠煥敵据 ? | Wanfeng Yang Jiawei Wang Conghui Si Zhangquan Peng Zhonghua Zhang | 2017 | Nano Research2017，10，8： | 0 |
| 6 | Phase-boundary regulation boosting electrochemical reactivity of tin-based anodes for magnesium-ion batteries显示文摘Tin(Sn)-based materials are promising anodes for magnesium-ion batteries(MIBs) owing to their low reaction voltages, high theoretical specific capacities and good compatibility with conventional electrolytes. However, relatively arduous alloying reaction and sluggish diffusion kinetics limit their practical applications. Herein, we proposed a general strategy to regulate the electrochemical reactivity and performance of Sn-based anodes for Mg storage through the introduction of the second phase and phase boundary. The biphase Sn–Al, Sn–Pb and Sn–Zn O films were further fabricated via magnetron co-sputtering. Taking Sn–Al as an example, it has been revealed that the introduction of Al can effectively stimulate the electrochemical reaction of Sn with Mg in either nanoscale or bulk through combining experiments with density-functional theory calculations. Specially, the rolled Sn–Al electrode exhibits superior long-term stability over 5,000 cycles. Additionally, the Mg-storage mechanism of the Sn–Al electrode was investigated by operando X-ray diffraction. The Sn–Al anodes also demonstrate good compatibility with simple Mg-salt-based electrolytes like Mg(TFSI)2in full cells. More importantly, it has been authenticated that the activation effect of second phase and phase boundary to Sn is also applicable to Pb and Zn O. Our findings may provide a favorable reference for the development of alloy-type anodes for MIBs. | Meijia Song Yan Wang Conghui Si Wenrun Cui Wanfeng Yang Guanhua Cheng Zhonghua Zhang | 2022 | Science China Chemistry2022，65，7： | 0 |
| 7 | Amorphous germanium-crystalline bismuth films as a promising anode for magnesium-ion batteries显示文摘Magnesium-ion batteries(MIBs)are promising alternatives to lithium-ion batteries due to their safety and high theoretical specific capacity,and the abundance of magnesium reserves.However,their anodes and electro-lytes severely restrict the development of MIBs,so alloy-type anodes provide an effective strategy to circum-vent the surface passivation issue encountered with Mg metal in conventional electrolytes.Theoretically,a germanium anode can deliver a high specific capacity of 1476 mAh g?1,but hitherto,no experimental reports have described Ge in MIBs.Herein,we experimentally verified that Ge could reversibly react with Mg 2þions through the design of dual-phase Ge–Bi film electrodes fabricated by magnetron co-sputtering.Notably,a Ge 57 Bi 43 electrode delivered a high specific capacity of 847.5 mAh g?1,owing to the joint alloying reactions of Ge and Bi with Mg,which was much higher than the specific capacity of Bi(around 385 mAh g?1).Moreover,the Ge–Bi anode showed excellent rate performance,good cycling stability,and superior compatibility with conventional electrolytes such as Mg(TFSI)2.More importantly,the Mg storage mechanism of the Ge–Bi anode was unveiled by operando X-ray diffraction,and density functional theory calculations rationalized that the introduction of Bi to form Ge–Bi evidently decreased the defect formation energy and effectively boosted the electrochemical reactivity of Ge with Mg. | Zhonghua Zhang Meijia Song Conghui Si Wenrun Cui Yan Wang | 2023 | eScience2023，3，1： | 0 |
| 8 | Self-templating synthesis and structural regulation of nanoporous rhodium-nickel alloy nanowires efficiently catalyzing hydrogen evolution reaction in both acidic and alkaline electrolytes显示文摘Highly active and stable electrocatalysts to produce hydrogen through water splitting are crucial for clean energy systems but are still challenging.Herein,a novel self-templating strategy was proposed to synthesize one-dimensional nanoporous RhNi alloy nanowires through combining metallurgical eutectic solidification and microalloying with chemical dealloying.In-situ X-ray diffraction and ex-situ characterizations reveal that the Al matrix served as a template to guide the growth of the Al3(Ni,Rh)nanowires during eutectic solidification of Al-Ni-Rh precursor and was completely removed in the dealloying process.Meanwhile,the nanowire morphology could be well retained and the dealloying of Al_(3)(Ni,Rh)led to the formation of nanoporous RhNi alloy nanowires.The length scale of the RhNi nanowires could be facilely regulated by changing the solidification conditions.More importantly,the RhNi catalysts show excellent electrocatalytic activity and stability towards hydrogen evolution reaction in both acidic and alkaline media,which has been rationalized by density functional theory calculations. | Zhihua Zhai Yan Wang Conghui Si Pan Liu Wanfeng Yang Guanhua Cheng Zhonghua Zhang | 2023 | Nano Research2023，16，2： | 0 |
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