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1篇 您的检索式:作者名="Congfeng Song"
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1MYB44 regulates PTI by promoting the expression of EIN2 and MPK3/6 in Arabidopsis显示文摘The plant signaling pathway that regulates pathogen-associated molecular pattern(PAMP)-triggered immunity(PTI)involves mitogen-activated protein kinase(MAPK)cascades that comprise sequential activation of several protein kinases and the ensuing phosphorylation of MAPKs,which activate transcription factors(TFs)to promote downstream defense responses.To identify plant TFs that regulate MAPKs,we investigated TF-defective mutants of Arabidopsis thaliana and identified MYB44 as an essential constituent of the PTI pathway.MYB44 confers resistance against the bacterial pathogen Pseudomonas syringae by cooperating with MPK3 and MPK6.Under PAMP treatment,MYB44 binds to the promoters of MPK3 and MPK6 to activate their expression,leading to phosphorylation of MPK3 and MPK6 proteins.In turn,phosphorylated MPK3 and MPK6 phosphorylate MYB44 in a functionally redundant manner,thus enabling MYB44 to activate MPK3 and MPK6 expression and further activate downstream defense responses.Activation of defense responses has also been attributed to activation of EIN2 transcription by MYB44,which has previously been shown to affect PAMP recognition and PTI development.AtMYB44 thus functions as an integral component of the PTI pathway by connecting transcriptional and posttranscriptional regulation of the MPK3/6 cascade.Zuodong Wang Xiaoxu Li Xiaohui Yao Jinbiao Ma Kai Lu Yuyan An Zhimao Sun Qian Wang Miao Zhou Lina Qin Liyuan Zhang Shenshen Zou Lei Chen Congfeng Song Hansong Dong Meixiang Zhang Xiaochen Chen 2023Plant Communications2023,4,6:0
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