维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

7篇 您的检索式：作者名="Conchillo A"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	Mitochondrial protection by low doses of insulin-like growth factor-Ⅰin experimental cirrhosis显示文摘AIM: To characterize the mitochondrial dysfunction in experimental cirrhosis and to study whether insulin-like growth factor-Ⅰ(IGF-Ⅰ) therapy (4 wk) is able to induce beneficial effects on damaged mitochondria leading to cellular protection. METHODS: Wistar rats were divided into three groups: Control group, untreated cirrhotic rats and cirrhotic rats treated with IGF-Ⅰtreatment (2 μg/100 g bw/d). Mitochondrial function was analyzed by flow cytometry in isolated hepatic mitochondria, caspase 3 activation was assessed by Western blot and apoptosis by TUNEL in the three experimental groups. RESULTS: Untreated cirrhotic rats showed a mitochon- drial dysfunction characterized by a significant reduction of mitochondrial membrane potential (in status 4 and 3); an increase of intramitochondrial reactive oxigen species (ROS) generation and a significant reduction of ATPase activity. IGF-Ⅰtherapy normalized mitochondrial func-tion by increasing the membrane potential and ATPase activity and reducing the intramitochondrial free radical production. Activity of the electron transport complexes Ⅰand Ⅲ was increased in both cirrhotic groups. In addition, untreated cirrhotic rats showed an increase of caspase 3 activation and apoptosis. IGF-Ⅰtherapy reduced the expression of the active peptide of caspase 3 and resulted in reduced apoptosis.	Raquel Pérez María García-Fernández Matías Díaz-Sánchez Juan E Puche Gloria Delgado Marian Conchillo Jordi Muntané Inma Castilla-Cortázar	2008	World Journal of Gastroenterology2008，14，17：	11
	2	Combined effect of cooking (grilling and roasting) and chilling storage (with and without air) on lipid and cholesterol oxidation in chicken breast显示文摘	CONCHILLO D A ASTIASARAN I	2003	Journal of Food Protection2003，66，5：	1
	3	Is type Ⅲ intestinal metaplasia an obligatory precancerous lesion in intestinal-type gastric carcinoma? 显示文摘	Conchillo JM Houben G de Bruine A	2001	Eur J Cancer Pre2001，10，4：	1
	4	Is type Ⅲ intestinal metaplasia an obligatnry precancerous lesion in intestinal-type gastric carcinoma? 显示文摘	Conchillo J M Houben G de Bruine A	2001	Eur J Cancer Prey2001，10，4：	1
	5	Insulin-like growth factor I (IGF-I)replacement therapy increases albumin concentration in liver cirrhosis:results of a pilot randomized controlled clinical trial显示文摘	Conchillo M de Knegt R J Payeras M Castilla-Cortazar I, Frystyk J, Flyvbjerg A, Yoshizawa C, Jansen PL, Scharschmidt B, Prieto J		0，，：	1
	6	Overexpression of GATA2 predicts an adverse prognosis for patients with acute myeloid leukemia and it is associated with distinct molecular abnormalities显示文摘	Vicente C Vazquez I Conchillo A	2011	Leukemia2011，26，3：	1
	7	Electrical stimulation therapy for gastroesophageal reflux disease显示文摘	Rinsma N F Bouvy N D Masclee A A Conchillo J M	2014	J Neurogastroenterol Motil2014，20，：	1

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费