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| 1 | Quantitative analysis of opioids and cannabinoids in wastewater samples显示文摘Wastewater-based epidemiology is an innovative approach that uses the analysis of human excretion products in wastewater to obtain information about exposure to drugs in defined population groups.We developed and validated an analytical method for the simultaneous determination of opioids(morphine,oxycodone,hydrocodone,oxymorphone and hydromorphone),and cannabinoids(△9-tetrahydrocannabinol,11-nor-9-carboxy-tetrahydrocannabinol(THCCOOH)and THCCOOH-glucuronide)in raw-influent wastewater samples by ultra-high performance liquid chromatography-tandem mass spectrometry.Method validation included linearity(5-1000 ng/L for opioids,10-1000 ng/L for cannabinoids),imprecision(<21.2%),accuracy(83%-131%),matrix effect(from-35.1%to-14.7%)and extraction efficiency(25%-84%),limit of detection(1-5 ng/L)and quantification(5-10 ng/L)and auto-sampler stability(no loss detected).River and wastewater samples were collected in triplicate from different locations in New York City and stored at-20℃until analysis.Water from sewage overflow location tested positive for morphine(10.7 ng/L),oxycodone(4.2-23.5 ng/L),oxymorphone(4.8 ng/L)and hydromorphone(4.2 ng/L).Raw influent wastewater samples tested positive for morphine(133.0-258.3 ng/L),oxycodone(31.1-63.6 ng/L),oxymorphone(16.0-56.8 ng/L),hydromorphone(6.8-18.0 ng/L),hydrocodone(4.0-12.8 ng/L)and THCCOOH(168.2-772.0 ng/L).This method is sensitive and specific for opioids and marijuana determination in wastewater samples. | Alethea Jacox Jillian Wetzel Shu-Yuan Cheng Marta Concheiro | 2017 | Forensic Sciences Research2017，2，1： | 3 |
| 2 | 3,4-Methylenedioxypyrovalerone (MDPV) and metabolites quantification in human and rat plasma by liquid chromatography-high resolution mass spectrometry显示文摘 | Anizan S Ellefsen K Concheiro M | 2014 | Analytica Chimica Acta2014，827，： | 1 |
| 3 | Influence of cationic cellulose structure on its interactions with sodium dodecylsulfate: implications on the properties of aqueous dispersions and hydrogels显示文摘 | Rodriguez R Alvarez-Lorenzo C Concheiro A | 2003 | European Journal of Pharmaceutics and Biopharmaceutics2003，56，1： | 1 |
| 4 | Preparation of chitosan beads by simultaneous eross-linkingAnsolubilisation in ba- sic Ph 显示文摘 | Barreiro-lglesias R Coronilla R Concheiro A | 2005 | European Journal of Pharmaceutical Sciences2005，24，1： | 1 |
| 5 | Simultaneous quantification of 28 synthetic cathinones and metabolites in urine by liquid chromatography-high resolution mass spectrometry 显示文摘 | Concheiro M Anizan S Ellefsen K | 2013 | Analytical and Bioanalytical Chemistry2013，405，29： | 1 |
| 6 | Molecularly imprinted polymers for drug delivery显示文摘 | Alvarez-Lorenzo C Concheiro A | 2004 | J Chromatogr B2004，19，4： | 1 |
| 7 | Molecularly imprinted polymers for drug delivery显示文摘 | ALVAREZ-LPRENZO C CONCHEIRO A | 2004 | J Chromator B2004，804，1： | 1 |
| 8 | Fast LC-MS/MS method for the determination of amphetamine,methamphetamine,MDA,MDMA,MDEA,MBDB and PMAin urine显示文摘 | Concheiro M Simes SMSS Quintelaó | 2007 | Forensic Sci Int2007，171，1： | 1 |
| 9 | Determination of illicit and medicinal drugs and their metabolites in oral fluid and preserved oral fluid by liquid chromatography-tandem mass spectrometry 显示文摘 | CONCHEIRO M CASTRO A QUINTELA O | 2008 | Anal Bioanal Chem2008，391，： | 1 |
| 10 | High-throughput simultaneous analysis of bu- prenorphine, methadone, cocaine, opiates, nicotine, and metabolites in oral fluid by liquid chromatography tandem mass spectrometry显示文摘 | CONCHEIRO M GRAY T R SHAKLEYA D M | 2010 | Anal Bioanal Chem2010，398，： | 1 |
| 11 | Temperature-sensitive chitosan-poly(N-isopropylacrylamide)interpenetrated networks with enhanced loading capacity and controlled release properties显示文摘 | Angel Concheiro Alexander S | 2005 | Journal of Controlled Release2005，102，3： | 1 |
| 12 | Reversible adsorptionby a pH-and temperature-sensitive acrylic hydrogel 显示文摘 | Alvarez-Lorenzo C Concheiro A | 2002 | Jcontrolled reZ2002，80，1： | 1 |
| 13 | Reversible adsorption by a pH-and temperature-sensitive acrylic hydrogel 显示文摘 | Alvarez-Lorenzo C Concheiro A | 2002 | J Controlled Release2002，80，2： | 1 |
| 14 | 查看详情显示文摘 | Alvarez-Lorenzo C Concheiro A | | 0，，11： | 1 |
| 15 | Development and validation of a liquid chromatography - tandem mass spectrometry assay for the simultaneous quantification of buprenorphine, norbuprenorphine, and metabolites in human urine显示文摘 | Kacinko SL Concheiro - Guisan M Shakleya DM | 2008 | Anal Bioanal Chem2008，392，5： | 1 |
| 16 | Intelligent drug delivery systems:polymeric micelles and hydrogels显示文摘 | Alvarez-Lorenzo C Concheiro A | 2008 | Mini Rev Med Chem2008，8，11： | 1 |
| 17 | Controlled release of estradiol solubilized in carbopol/surfactant aggregates显示文摘 | Barreiro- iglesias R Alvarez- lorenzo C Concheiro A | 2003 | J Controlled Release2003，93，： | 1 |
| 18 | Poly (acrylic acid) microgels (carbopol 934) / surfactant interactions in aqueous media: Part I : Nonionic surfactants显示文摘 | Barreiro I R Alvarez L C Concheiro A | 2003 | International Journal of Pharma ceutics2003，258，12： | 1 |
| 19 | Cationic cellulose hydrogels:kinetics of the cross-linking process and characterization as pH-/ion-sensitive drug delivery systems显示文摘 | Alvarez-Lorenzo C Concheiro A | 2003 | Journal of Controlled Release2003，86，23： | 1 |
| 20 | Biophysical characterization of complexation of DNA with block copolyrners ofpoly(2-dimethylaminoethyl) methacrylate, poly(ethyle- ne oxide), and poly(propylene oxide)显示文摘 | Carmen Alvarez-Lorenzo Rafael Barreiro-lglesias Angel Concheiro | 2005 | Langmuir2005，21，： | 1 |
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