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| 1 | Partially hydrolyzed guar gum in pediatric functional abdominal pain显示文摘AIM:To assess the effects of partially hydrolyzed guar gum(PHGG) diet supplement in pediatric chronic abdominal pain(CAP) and irritable bowel syndrome(IBS).METHODS:A randomized,double-blind pilot study was performed in sixty children(8-16 years) with functional bowel disorders,such as CAP or IBS,diagnosed according to Rome Ⅲ criteria.All patients underwent ultrasound,blood and stool examinations to rule out any organic disease.Patients were allocated to receive PHGG at dosage of 5 g/d(n = 30) or placebo(fruitjuice n = 30) for 4 wk.The evaluation of the efficacy of fiber supplement included IBS symptom severity score(Birmingham IBS Questionnaire),severity of abdominal pain(Wong-Baker Face Pain Rating Score) and bowel habit(Bristol Stool Scale).Symptom scores were completed at 2,4,and 8 wk.The change from baseline in the symptom severity scale at the end of treatment and at 4 wk follow-up after treatment was the primary endpoint.The secondary endpoint was to evaluate compliance to supplementation with the PHGG in the pediatric population.Differences within groups during the treatment period and follow-up were evaluated by the Wilcoxon signed-rank test.RESULTS:The results of the study were assessed considering some variables,such as frequency and intensity of symptoms with modifications of the bowel habit.Both groups were balanced for baseline characteristics and all patients completed the study.Group A(PHGG group) presented a higher level of efficacy compared to group B(control group),(43% vs 5%,P = 0.025) in reducing clinical symptoms with modification of Birmingham IBS score(median 0 ± 1 vs 4 ± 1,P = 0.025),in intensity of CAP assessed with the Wong-Baker Face Pain Rating Score and in normalization of bowel habit evaluated with the Bristol Stool Scale(40% vs 13.3%,P = 0.025).In IBS subgroups,statistical analysis shown a tendency toward normalization of bowel movements,but there was no difference in the prevalence of improvement in two bowel habit subsets.PHGG was therefore better tolerated without any adverse effects.CONCLUSION:Although the cause of pediatric functional gastrointestinal disorders is not known,the results show that complementary therapy with PHGG may have beneficial effects on symptom control. | Claudio Romano Donatella Comito Annalisa Famiani Sabrina Calamarà Italia Loddo | 2013 | World Journal of Gastroenterology2013，19，2： | 3 |
| 2 | Globular adiponectin induces differentiation and fusion of skeletal muscle cells显示文摘对骨胳的肌肉新生的成长兴趣在损伤,以及几个肌肉发达的退化病理以后为肌肉损害与新治疗学的策略的开始被联系,包括营养障碍,肌肉发达的萎缩,和极度瘦弱。集中于细胞外的因素的能力支持 myogenesis 的研究因此是高度有希望的。我们现在报导那一个导出 adipocyte 的因素,球状的 adiponectin (荡者) ,能导致肌肉基因表示和房间区别。除它在肌肉调整几新陈代谢的功能的著名能力以外,包括葡萄糖举起和消费和丰满的酸分解代谢,荡者能堵住 myoblasts 的房间周期入口,到导致象肌浆球蛋白那样的特定的骨胳的肌肉标记的表示重链或 caveolin-3 ,象一样挑起房间熔化进 multinucleated syncytia 并且,最后肌肉纤维形成。荡者通过 p38, Akt 和 5 鈥 ? 的氧化还原作用依赖者激活施加它的 pro-differentiative 活动激活安培的蛋白质 kinase 小径。有趣地,区分 myoblasts 是为 adiponectin 的 autocrine,并且到氧化应力的支持 inflammatory 背景或暴露的 mimicking 强烈从区分房间增加荷尔蒙的生产。这些数据建议 adiponectin 的一个新奇函数,直接协调 myogenic 区别程序并且在骨胳的 myogenesis 期间服务一个 autocrine 函数。 | Tania Fiaschi Domenico Cirelli Giuseppina Comito Stefania Gelmini Giampietro Ramponi Mario Serio Paola Chiarugi | 2009 | Cell Research2009，19，5： | 2 |
| 3 | HIF - 1α stabilization by mitoehondrial ROS promotes Met - dependent invasive growth and vasculogenie mimicry in melanoma ceils 显示文摘 | Comito G Calvani M Giannoni E | 2011 | Free Radie Biol Med2011，12，： | 1 |
| 4 | HIF - 1α stabilization by mitochondrial ROS promotes Met - dependent invasive growth andvasculogenic mimicry in melanoma cells显示文摘 | Comito G Calvani M Giannoni E | 2011 | Free Radic Biol Med2011，51，4： | 1 |
| 5 | Grid services: principles, implementations and use显示文摘 | Comito C talia D Trunfio P | 2005 | Int J Web and Grid Services2005，1，1： | 1 |
| 6 | Senescent stroma promotes prostate cancer progression: The role of miR- 210 显示文摘 | Taddei ML Cavallini L Comito G | 2014 | MolOncol2014，8，8： | 1 |
| 7 | Is Stereotactic Body Radiation Therapy an Attractive Option for Unresectable Liver Metastases? A Preliminary Report from a Phase II Trial显示文摘 | Marta Scorsetti Stefano Arcangeli Angelo Tozzi Tiziana Comito Filippo Alongi Pierina Navarria Pietro Mancosu Giacomo Reggiori Antonella Fogliata Guido Torzilli Stefano Tomatis Luca Cozzi | 2012 | International Journal of Radiation Oncology Biology Physics2012，，： | 1 |
| 8 | Senescent stroma promotes prostate cancer progression: the role of miR-210 显示文摘 | Taddei ML Cavallini L Comito G | 2014 | Mol Oncol2014，8，8： | 1 |
| 9 | Proton pump inhibitors in pediatrics:evaluation of efficacy in GERD therapy显示文摘 | Romano C Chiaro A Comito D | | 0，，01： | 1 |
| 10 | Cancer-associated fibroblasts and M2-polarized macrophages synergize during pros tate carcinoma progression显示文摘 | Comito G Giammomi E Segura CP | 2014 | Oncogene2014，33，19： | 1 |
| 11 | HIF-1α stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells显示文摘 | Comito G Calvani M Giannoni E | 2011 | Free Radic Biol Med2011，51，4： | 1 |
| 12 | Pulmonary embolism in pregnancy显示文摘 | E. Conti L. Zezza E. Ralli C. Comito L. Sada J. Passerini D. Caserta S. Rubattu C. Autore M. Moscarini M. Volpe | 2014 | Journal of Thrombosis and Thrombolysis2014，，3： | 1 |
| 13 | Stereotactic body radiation therapy for liver metastases显示文摘 | Scorsetti M Clerici E Comito T | 2014 | J Gastrointest Oncol2014，5，3： | 1 |
| 14 | Norepinephrine promotestumor microenvironment reactivity through P3-adrenoreceptorsduring melanoma progression 显示文摘 | Calvani M Pelon F Comito G | 2015 | Oncotarget2015，6，7： | 1 |
| 15 | Proton pump inhibitors in pediatrics: evaluation of efficacy in GERD therapy显示文摘 | Romano C Chiaro A Comito D | 2011 | Curr Clin Pharmacol2011，6，1： | 1 |
| 16 | A Service-oriented System for Distributed Data Queryingand Integration on Grids显示文摘 | Comito C Gounafis A Sakellariou tL | 2009 | Future Generation Computer Systems2009，25，5： | 1 |
| 17 | Immunotherapy for Epstein-Barr virus-associated tumors 显示文摘 | Comito MA Sun Q Lucas KG | 2004 | Leuk Lymphoma2004，45，10： | 1 |
| 18 | A case-control study of quality of life and functional impairment in women with long-standing vertebral osteoporotic fracture显示文摘 | Hall SE Criddh RA Comito TL | 1999 | Osteoporos Int1999，9，： | 1 |
| 19 | Cancer-as- sociated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression显示文摘 | COMITO G GIANNONI E SEGURA C P | 2014 | Oncogene2014，33，19： | 1 |
| 20 | Stromal fibroblasts synergize with hypoxic oxidative stress to enhance melanoma aggressiveness 显示文摘 | Comito G Giannoni E Di Gennaro P | 2012 | Cancer Lctt2012，324，1： | 1 |
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