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| 1 | Toward a 'Greener' revolution 显示文摘 | WELCH R M COMBS Jr G F DUXBURY J M | 1997 | Issues in Science and Technology1997，14，： | 1 |
| 2 | Relationship between plasma ghucose, brain actate and intracell Ular PH daring cerebralis chemiain gerbils显示文摘 | Combs DJ Deinpsey R Maley M | 1990 | Strock1990，21，5： | 1 |
| 3 | An overall strategy for the testing of chemicals for human hazard and risk assessment under the EU REACH system显示文摘 | Combes R Barratt M Balls M | 2003 | ATLA - Alternatives to Laboratory Animals2003，31，1： | 1 |
| 4 | An overall strategy for the testing of chemicals for human hazard and risk assessment under the EU REACH system 显示文摘 | COMBES R BARRATr M BALLM S | 2003 | Altern Lab Anim2003，31，1： | 1 |
| 5 | Two SEM techniquesto investigate reservoir-rock wettability显示文摘 | ROBIN M COMBES R CUIEC L | 1998 | Journal ofpetroleum technology1998，50，11： | 1 |
| 6 | Beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes显示文摘 | McDonald D R Bamberger M E Combs C K | 1998 | J Neurosci1998，18，12： | 1 |
| 7 | Free-radical telomerization of tetrafluoroethylene in supercritical carbon dioxide显示文摘 | Romack T J Combes J R DeSimone J M | 1995 | Macromol1995，28，： | 1 |
| 8 | Cryo-SEM and ESEM s new techniques tO investigate phase interactions within reservoir rocks显示文摘 | Robin M Combes R Rosenberg E | 1999 | SPE 568291999，，： | 1 |
| 9 | Quantitative analysis of sulfur dioxide with passive Fourier transform infrared remote sensing intefferogram data 显示文摘 | MATTU M J SMALL G W COMBS R J | 2000 | Applied Spectroscopy2000，54，3： | 1 |
| 10 | Cell transformation assay as predictors of human carcinogenicity: the report and recommendation of ECVAM Workshop 39显示文摘 | COMBES R BALLS M CURREN R | 1999 | ATLA1999，27，： | 1 |
| 11 | AABB technical manual16thed显示文摘 | Roback J D Combs M R Grossman B J | 2008 | Betheda: AABB press2008，36，27： | 1 |
| 12 | The two directions of TNF-related apoptosis-inducing ligand in rheumatoid arthritis显示文摘 | Audo R Combe B Hahne M | 2013 | Cytokine2013，63，2： | 1 |
| 13 | The monosodium iodoacetatemodel of osteoarthritis:a model of chronic nociceptlve pain in rats? 显示文摘 | Combe R Bramwell S Field M J | 2004 | Neurosci Lett2004，370，： | 1 |
| 14 | Fungal endophyte increases the al- lelopathic effects of an invasive forb显示文摘 | ASCHEHOUG E T CALLAWAY R M NEW- COMBE G | 2014 | Oecologia2014，175，1： | 1 |
| 15 | Toward a ‘Greener' revolution显示文摘 | Welch R M Combs G F Jr Duxbury J M | 1997 | Issues Sci Tech1997，14，： | 1 |
| 16 | Applying the three RS to animal experimentation and animal testing : are we merely drifting or lying at anchor ?显示文摘 | Balls M Combes R | 2006 | ATLA2006，34，： | 1 |
| 17 | High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy显示文摘BACKGROUND Liver transplantation(LT)presents a curative treatment option in patients with early stage hepatocellular carcinoma(HCC)who are not eligible for resection or ablation therapy.Due to a risk of up 30%for waitlist drop-out upon tumor progression,bridging therapies are used to halt tumor growth.Transarterial chemoembolization(TACE)and less commonly stereotactic body radiation therapy(SBRT)or a combination of TACE and SBRT,are used as bridging therapies in LT.However,it remains unclear if one of those treatment options is superior.The analysis of explant livers after transplantation provides the unique opportunity to investigate treatment response by histopathology.AIM To analyze histopathological response to a combination of TACE and SBRT in HCC in comparison to TACE or SBRT alone.METHODS In this multicenter retrospective study,27 patients who received liver transplantation for HCC were analyzed.Patients received either TACE or SBRT alone,or a combination of TACE and SBRT as bridging therapy to liver transplantation.Liver explants of all patients who received at least one TACE and/or SBRT were analyzed for the presence of residual vital tumor tissue by histopathology to assess differences in treatment response to bridging therapies.Statistical analysis was performed using Fisher-Freeman-Halton exact test,Kruskal-Wallis and Mann-Whitney-U tests.RESULTS Fourteen patients received TACE only,four patients SBRT only,and nine patients a combination therapy of TACE and SBRT.There were no significant differences between groups regarding age,sex,etiology of underlying liver disease or number and size of tumor lesions.Strikingly,analysis of liver explants revealed that almost all patients in the TACE and SBRT combination group(8/9,89%)showed no residual vital tumor tissue by histopathology,whereas TACE or SBRT alone resulted in significantly lower rates of complete histopathological response(0/14,0%and 1/4,25%,respectively,P value<0.001).CONCLUSION Our data suggests that a combination of TACE and SBRT increases the rate of complete histopathological response compared to TACE or SBRT alone in bridging to liver transplantation. | Ulrike Bauer Sabine Gerum Falk Roeder Stefan Münch Stephanie E Combs Alexander B Philipp Enrico N De Toni Martha M Kirstein Arndt Vogel Carolin Mogler Bernhard Haller Jens Neumann Rickmer F Braren Marcus R Makowski Philipp Paprottka Markus Guba Fabian Geisler Roland M Schmid Andreas Umgelter Ursula Ehmer | 2021 | World Journal of Gastroenterology2021，27，24： | 1 |
| 18 | Singlecolumn purification of free recombinant proteins using a self-cleavable affinity tag derived from a protein splicing element 显示文摘 | CHONG S R COMB D G SCOTT M E | 1997 | Gene1997，192，2： | 1 |
| 19 | A comparison of methods for calculating audible noise of high voltage transmission lines 显示文摘 | COMBES M G CARBERRY R E CHARTIER V L | 1982 | IEEE Transactions on Power Apparatus and Systems1982，101，10： | 1 |
| 20 | Freeradical telomerization of tetrafluoroethylene in supercritical carbon dioxide 显示文摘 | ROMACK T J COMBES J R DESIMONE J M | 1995 | Macromolecules1995，28，5： | 1 |
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