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| 1 | Structure and Dynamics of the Isoprenoid Pathway Network显示文摘Isoprenoids 是机能上地并且植物代谢物的最多样的组迄今为止报导了的在结构上。他们能作为主要代谢物工作,参予必要植物细胞的进程,和同样第二等的代谢物,许多有实质的广告,药理学,和农业价值。Isoprenoid 结束产品在 synergistically 两个都在他们行动的大量生理的过程参予植物,例如在光合作用期间的叶绿素和类胡萝卜素,或反对地,例如 gibberellic 酸和在种子萌芽期间酸的 abscisic。这因此被期望经由 isoprenoid 的流动新陈代谢的网络紧时间地并且空间地被控制,并且这控制在全部 isoprenoid 上发生在规定并且以一种安排方式的不同层次新陈代谢的网络。在这评论,我们在跟随多样的刺激的基因表达式水平总结我们植物 isoprenoid 小径网络和它的规定的拓扑学的当前的知识。我们由讨论从植物 isoprenoid 新陈代谢出现的 agronomical 和 biotechnological 应用程序得出结论并且在植物 isoprenoid 小径网络的系统分析在未来方向上提供眼界。 | Eva Vranova Diana Coman Wilhelm Gruissem | 2012 | Molecular Plant2012，5，2： | 18 |
| 2 | Training in endoscopic submucosal dissection显示文摘Endoscopic submucosal dissection (ESD) represents an important advancement in the therapy of early neoplastic gastrointestinal lesions by providing higher en-bloc curative resection rate with lower recurrence compared to endoscopic mucosal resection (EMR) and by sparing the involved organ and protecting patient' s quality of life. Despite these advantages ESD is associated with long procedure times and a higher rate of complications, making ESD a challenging procedure which requires advanced endoscopic skills. Thus, there has been a recognized need for structured training system for ESD to enhance trainee experience and, to reduce the risks of complications and inadequate treatment. ESD has a very flat learning curve. However, we do not have uniformly accepted benchmarks for competency. Nevertheless, it appears that, in Japan, more than 30 supervised gastric ESD procedures are required to achieve technical proficiency and minimize complications. A number of training algorithms have been pro-posed in Japan with the aim to standardize ESD training. These algorithms cannot be directly applied in the West due to substantial differences including the availability of highly qualified mentors, the type of pathology seen, choice of devices, and trainee's background. We propose a training algorithm for Western physicians which integrates both hands-on training courses, animal model work as well as visits to expert centers. No specific preceptor training programs have been yet developed but there is a consensus that these programs are important for permeation of ESD worldwide. | Roxana M Coman Takuji Gotoda Peter V Draganov | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，8： | 8 |
| 3 | Role of observation of live cases done by Japanese experts in the acquisition of ESD skills by a western endoscopist显示文摘AIM:To evaluate the role of observation of experts performing endoscopic submucosal dissection(ESD)in the acquisition of ESD skills.METHODS:This prospective study is documenting the learning curve of one Western endoscopist.The study consisted of three periods.In the first period(preobservation),the trainee performed ESDs in animal models in his home institution in the United States.The second period(observation)consisted of visit to Japan and observation of live ESD cases done by experts.The observation of cases occurred over a 5-wk period.During the third period(post-observation),the trainee performed ESD in animal models in a similar fashion as in the first period.Three animal models were used:live40-50 kg Yorkshire pig,explanted pig stomach model,and explanted pig rectum model.The outcomes from the ESDs done in the animal models before and after observation of live human cases(main study intervention)were compared.Statistical analysis of the data included:Fisher’s exact test to compare distributions of a categorical variable,Wilcoxon rank sum test to compare distributions of a continuous variable between the two groups(pre-observation and post-observation),and Kruskal-Wallis test to evaluate the impact of lesion location and type of model(ex-vivo vs live pig)on lesion removal time.RESULTS:The trainee performed 38 ESDs in animal model(29 pre-observation/9 post-observation).The removal times post-observation were significantly shorter than those pre-observation(32.7±15.0 min vs 63.5±9.8 min,P<0.001).To minimize the impact of improving physician skill,the 9 lesions post-observation were compared to the last 9 lesions pre-observation and the removal times remained significantly shorter(32.7±15.0 min vs 61.0±7.4 min,P=0.0011).Regression analysis showed that ESD observation significantly reduced removal time when controlling for the sequence of lesion removal(P=0.025).Furthermore,it was also noted a trend towards decrease in failure to remove lesions and decrease in complications after the period of observation.This study did not find a significant difference in the time needed to remove lesions in different animal models.This finding could have important implications in designing training programs due to the substantial difference in cost between live animal and explanted organ models.The main limitation of this study is that it reflects the experience of a single endoscopist.CONCLUSION:Observation of experts performing ESD over short period of time can significantly contribute to the acquisition of ESD skills. | Peter V Draganov Myron Chang Roxana M Coman Mihir S Wagh Qi An Takuji Gotoda | 2014 | World Journal of Gastroenterology2014，20，16： | 3 |
| 4 | Assessment of the plug flow and dead volume ratios in a sub-surface horizontal-flow packed-bed reactor as a representative model of a sub-surface horizontal constructed wetland显示文摘 | David Jafet Rodríguez Alcocer Germán Giácoman Vallejos Pascale Champagne | 2011 | Ecological Engineering2011，，： | 2 |
| 5 | Mechanisms of aqueous wollastonite carbonation as a possible CO 2 sequestration process显示文摘 | Wouter J.J. Huijgen Geert-Jan Witkamp Rob N.J. Comans | 2006 | Chemical Engineering Science2006，，13： | 2 |
| 6 | A double-blind,randomized,placebo-controlled trial of macrolide in the treatment of chronic rhinosinusitis显示文摘 | Wallwork B Coman W Mackay-Sirm A | | 0，，2： | 1 |
| 7 | WGEMLab: simulation platform for the analysis of rectangular waveguide aperture radiation 显示文摘 | Lager I E Coman C I Hoop A T | 2003 | IEEE Transactions on Magnetics2003，39，3： | 1 |
| 8 | Transcription and protein expression of mb-1 and B29 genes in human hematopoietic malignancies and cell lines显示文摘 | Verschuren MCM Comans Bitter WM Kapteijin CAC | 1993 | Leukemia1993，7，： | 1 |
| 9 | Sorption andsorption reversibility of cadmium on calcite in the presence of phosphate and sulfate显示文摘 | RD Van der Weijden J Meima RNJ Comans | 1997 | Mar Chem1997，57，12： | 1 |
| 10 | Sentinel lymph node biopsy in breast cancer :guidelines and pitfalls of lymphoscintigraphy and gamma probe detection显示文摘 | Borgstein PJ Pijpers R Comans EF | | 0，，： | 1 |
| 11 | Sorption of cadmium on hydroxyapatite 显示文摘 | MIDDELBURG J J COMANS R N | 1991 | Chemical Geology1991，90，： | 1 |
| 12 | Present problems of intra-and extra-lobar pulmonary sequestration显示文摘 | Coman C Stan A Georgescu G | 1973 | Poumon Coeur1973，29，2： | 1 |
| 13 | Evalua- tion of egg and nauplii production parameters of a sin- gle stock of domesticated Penaeus monodon (giant tiger shrimp) across generations 显示文摘 | Coman G J Arnold S J Wood A T | 2013 | Aqua2013，，400401： | 1 |
| 14 | Selective inhibittion of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors 显示文摘 | Pelletier JP Lascau- Coman V Jovanovic D | 1999 | J Rheumatol1999，26，： | 1 |
| 15 | A comparison of the influence of lanthanum and fluoride on de-and remineralization of bovine enamel in vitro显示文摘 | Collys KL Delanhe G Comans D | 1990 | J Dent Res1990，69，2： | 1 |
| 16 | Real-time RT-PCR quantification of Kuruma shrimp transcripts: A comparison of relative and absolute quantification procedures显示文摘 | Melony J. Sellars Tony Vuocolo Lisa A. Leeton Greg J. Coman Bernard M. Degnan Nigel P. Preston | 2007 | Journal of Biotechnology2007，，3： | 1 |
| 17 | Sentinel lymph node biospy in breast cancer:guidelines and pitfalls of lymphoscin-tigraphy and gamma probe detection显示文摘 | Borgstein PJ Pijpers R Comans EF | 1998 | J Am Coll Surg1998，186，3： | 1 |
| 18 | Selective inhibi- tion of inducible nitric oxide synthase in experimental oateoarthritis is associated with reduction intissue levels of catabolic factors显示文摘 | Pelletier JP Lascau - Coman V J Jovanovic D | 1999 | Rheu- matot1999，26，： | 1 |
| 19 | Mineral CO2 sequestration by steel slag carbonation 显示文摘 | Huijgen W J J Witkamp G J Comans R N J | 2005 | Environmental Science and Technology2005，39，96： | 1 |
| 20 | Network analysis of the MVA and MEP pathways for isoprenoid synthesis 显示文摘 | Vranova E Coman D Gruissem W | 2013 | Annual Review of Plant Biology2013，64，： | 1 |
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