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| 1 | 从胚胎的干细胞塑造眼睛: 生物、医药的含意显示文摘 Organogenesis is regulated by a complex network of intrinsic cues, diffusible signals and cell/cell or cell/matrix interactions that drive the cells of a prospective organ to differentiate and collectively organize in three dimensions. Generating organs in vitro from embryonic stem (ES) cells may provide a simplified system to decipher how these processes are orchestrated in time and space within particular and between neighboring tissues. Recently, this field of stem cell research has also gained considerable interest for its potential applications in regenerative medicine. Among human pathologies for which stem cell-based therapy is foreseen as a promising therapeutic strategy are many retinal degenerative diseases, like retinitis pigmentosa and age-related macular degeneration. Over the last decade, progress has been made in producing ES-derived retinal cells in vitro, but engineering entire synthetic retinas was considered beyond reach. Recently however, major breakthroughs have been achieved with pioneer works describing the extraordinary self-organization of murine and human ES cells into a three dimensional structure highly resembling a retina. ES-derived retinal cells indeed assemble to form a cohesive neuroepithelial sheet that is endowed with the intrinsic capacity to recapitulate, outside an embryonic environment, the main steps of retinal morphogenesis as observed in vivo. This represents a tremendous advance that should help resolving fundamental questions related to retinogenesis. Here, we will discuss these studies, and the potential applications of such stem cell-based systems for regenerative medicine. | Gabriele Colozza Morgane Locker Muriel Perron | 2012 | World Journal of Stem Cells2012，4，8： | 2 |
| 2 | Value of Ki67 in breast cancer: the debate is still open 显示文摘 | Colozza M Sidoni A Piccart-Gebhart M | 2010 | Lancet On col2010，11，5： | 1 |
| 3 | EGFR,pMAPK,pAkt and PTEN status by immunohistochemistry:correlation with clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab显示文摘 | Gori S Sidoni A Colozza M Ferri I Mameli MG Fenocchio D | 2009 | Ann Oncol2009，20，4： | 1 |
| 4 | Evaluation of serum HER2 extracellular domain in early breast cancer patients: correlation with clinicopathological parameters and survival 显示文摘 | Ludovini V Gori S Colozza M | 2008 | Ann Oncol2008，19，5： | 1 |
| 5 | Epirubicin versus CMF as adjuvant therapy for stage I and II breast cancer: A prospective randomized study显示文摘 | Colozza M Bisagni G Mosconi A | 2002 | Eur J Cancer2002，38，： | 1 |
| 6 | CagA and VacA Helicobaeter pylori antibodies in gastric cancer显示文摘 | Suriani R Colozza M Cardesi E | 2008 | Can J Gastroenterol2008，22，3： | 1 |
| 7 | CagA and VacA Helicobacter pylori antibodies in gastric cancer显示文摘 | Suriani R Colozza M Cardesi E | 2008 | Cancer J Gastroenterol2008，22，3： | 1 |
| 8 | CagA and VacA Helicobacter pylori antibodies in gastric cancer显示文摘 | Suriani R Colozza M Cardesi E | 2008 | Cancer J Gastroenterol2008，22，3： | 1 |
| 9 | Extended survival of a HER-2-positive metastatic breast cancer patient with brain metastases also treated with intrathecal trastuzumab显示文摘 | Mariantonietta Colozza Elisa Minenza Stefania Gori Daniela Fenocchio Cristina Paolucci Cynthia Aristei Piero Floridi | 2009 | Cancer Chemotherapy and Pharmacology2009，，6： | 1 |
| 10 | Proliferative markers as prognostic and predictive tools in early breast cancer: where are we now?显示文摘 | Colozza M Azambuja E Cardoso F | 2005 | Ann Oncol2005，16，11： | 1 |
| 11 | Epirubicin versus CMF as adjuvant therapy for stage I and II breast cancer:A prospective randomized study显示文摘 | Colozza M Bisagni G Mosconi A | 2012 | Eur J Cancer2012，38，17： | 1 |
| 12 | Evaluation of serum HER2 extracellular domain in early breast cancer pa- tients: correlation with clinicopathological parameters and survival显示文摘 | Ludovini V Gori S Colozza M | 2008 | Ann Oncol2008，19，5： | 1 |
| 13 | Long-tern1 toxic effects of adjuvant chemotherapy in breast cancer显示文摘 | Azim HA Jr de Azambuja E Colozza M | 2011 | Ann Oncol2011，22，9： | 1 |
| 14 | ERCC1 expression in triple negative breast carcinoma: the paradox revisited显示文摘 | Angelo Sidoni Fabio Cartaginese Mariantonietta Colozza Stefania Gori Lucio Crinó | 2008 | Breast Cancer Research and Treatment2008，，3： | 1 |
| 15 | Evaluation of serum HER2 extracellular domain in early breast cancer patients: cor- relation with clinicopathological parameters and survival 显示文摘 | Ludovini V Gori S Colozza M | 2008 | Ann Oneol2008，19，5： | 1 |
| 16 | Breast cancer:achievements in adjuvant systemic therapies in the pre-genomic era显示文摘 | Colozza M de Azambuja E Cardoso F | 2006 | Oncologist2006，11，： | 1 |
| 17 | CagA and VacA Helicobacter pylori antibodies in gastric cancer 显示文摘 | Suriani R Colozza M Cardesi E | 2008 | Cancer J Gastroenterol2008，22，3： | 1 |
| 18 | Long-term toxic effects of adjuvant chemotherapy in breast cancer显示文摘 | Azim HA Jr de Azambuja E Colozza M | 2011 | Ann Oncol2011，22，9： | 1 |
| 19 | In vitro activities of amphotericin B and AmBisome against Aspergillus isolates re- covered from Italian patients treated for haematological malig- nancies显示文摘 | Colozza C Posteraro B Santilli S | 2012 | Int J Antimicrob Agents2012，39，5： | 1 |
| 20 | Proliferative markers as prognostic and predictive tools in early breast cancer: where are we- now? 显示文摘 | Colozza M Azambuja E Cardoso F | 2005 | Ann Oncol2005，16，11： | 1 |
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