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| 1 | Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia显示文摘Functional gastrointestinal disorders(FGID) are common clinical syndromes diagnosed in the absence of biochemical,structural,or metabolic abnormalities. They account for significant morbidity and health care expenditures and are identifiable across variable age,geography,and culture. Etiology of abdominal pain associated FGIDs,including functional dyspepsia(FD),remains incompletely understood,but growing evidence implicates the importance of visceral hypersensitivity and electromechanical dysfunction. This manuscript explores data supporting the role of visceral hypersensitivity and electromechanical dysfunction in FD,with focus on pediatric data when available,and provides a summary of potential therapeutic targets. | John M Rosen Jose T Cocjin Jennifer V Schurman Jennifer M Colombo Craig A Friesen | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 16 |
| 2 | Eosinophils and mast cells as therapeutic targets in pediatric functional dyspepsia显示文摘There is an increasing appreciation for the importance of inflammation as a pathophysiologic entity that contributes to functional gastrointestinal disorders including functional dyspepsia(FD).Importantly,inflammation may serve as a mediator between psychologic and physiologic functions.This manuscript reviews the literature implicating two inflammatory cell types,mast cells and eosinophils,in the generation of dyspeptic symptoms and explores their potential as targets for the treatment of FD.There are a number of inciting events which may initiate an inflammatory response,and the subsequent recruitment and activation of mast cells and eosinophils.These include internal triggers such as stress and anxiety,as well as external triggers such as microbes and allergens.Previous studies suggest that there may be efficacy in utilizing medications directed at mast cells and eosinophils.Evidence exists to suggest that combining 'anti-inflammatory' medications with other treatments targeting stress can improve the rate of symptom resolution in pediatric FD. | Craig A Friesen Jennifer V Schurman Jennifer M Colombo Susan M Abdel-Rahman | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，4： | 4 |
| 3 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 4 | Cutting balloon angioplasty for the treatment of in-stent restenosis:a matched comparison with rotational atherectomy,additional stent implantation and balloon angioplasty显示文摘 | ADAMIAN M COLOMBO A BRIGUORI C | 2001 | J Am Coll Cardiol2001，38，： | 1 |
| 5 | Aggressive surgical strategies in advanced ovarian cancer:a mono- centric study of 203 stage Ⅲ C and IV patients显示文摘 | Colombo PE Mourregot A Fabbro M | 2009 | Eur J Surg Oncol2009，35，2： | 1 |
| 6 | Degradation of toxic halogenated organie compounds by iron-containing mono-,bi- and tri-metallie particles in water 显示文摘 | COLOMBO A DRAGONETTI C MAGNI M | 2015 | lnorganica Chimiea Aeta2015，431，： | 1 |
| 7 | Recent progress and new trends in the treatment of hepatitis B显示文摘 | ALBERTI A BRUNETTO MR COLOMBO M | 2002 | J Med Virol2002，67，3： | 1 |
| 8 | Hepatocellular carcinoma in Italian patients with cirrhosis显示文摘 | Colombo M de Franchis R Del Ninno E Sangiovanni A De Fazio C Tommasini M | | New England Journal of Medicine0，，： | 1 |
| 9 | Recent progress and newtrends in the treatment of hepatitis B 显示文摘 | Alberti A Brunetto MR Colombo M | 2002 | J Med Virol2002，67，： | 1 |
| 10 | Pegylated IFN-alpha2a and ribavirin in the treatment of hepatitis C 显示文摘 | Aghemo A Rumi MG Colombo M | 2009 | Expert Rev Anti Infect Ther2009，7，8： | 1 |
| 11 | A general synthesis of water soluble upper rim calix arene guanidinium derivatives which bind to plasmid DNA显示文摘 | Dudic M Colombo A Sansone F | 2004 | Tetrahedron2004，60，11： | 1 |
| 12 | Click chemistry for the synthesis of RGD-containing integrin ligands 显示文摘 | Colombo M Bianchi A | 2010 | Molecules2010，15，1： | 1 |
| 13 | Risk factors for break through candidemia显示文摘 | Colombo A L | 2002 | Eur J Clin Microb Infect Dis2002，21，3： | 1 |
| 14 | Cutting balloon angioplasty for the treatment of in-stent restenosis: a matched comparison with rotational atherectomy, additional stent implantation and angioplasty显示文摘 | Adamian M Colombo A Briguori C | 2001 | J Am Coll Cardiol2001，38，： | 1 |
| 15 | Reduced DAT and DBH immunostaining in the limbic system of Sardinian alcohol-preferring rats 显示文摘 | CASU M A DINUCCI D COLOMBO G | 2002 | Brain Research2002，948，12： | 1 |
| 16 | Small chamber tests and headspace analysis of volatile organic compounds emitted from household products显示文摘 | Colombo A Bortoli M D Knoppel H | 1991 | Indoor Air1991，1，1： | 1 |
| 17 | Estimation of Leaf and Canopy Water Content in Poplar Plantations by Means of Hyperspectral Indices and Inverse Modeling 显示文摘 | Colombo R Meroni M Marchesi A | 2008 | Remote Sensing of Environment2008，112，： | 1 |
| 18 | Estimation of leaf and canopy water content in poplar plantations by means of hyperspectral indices and inverse modeling显示文摘 | Colombo R Meroni M Marcbesi A | 2008 | Remote Sensing of Environment2008，112，4： | 1 |
| 19 | Comparison of two methods for weaning patients with chronic obstructive pulmonary disease requiring mechanical ventilation for more than 15 days显示文摘 | Vitacca M Vianello A Colombo D | 2001 | Am J Respir Crit Care Med2001，164，2： | 1 |
| 20 | Globald- istribution and outcomes for Candida species causing invasive candidiasis: results from an international ran domized double-blind study of caspofungin versus am- photeriein B for the treatment of invasive candidiasis显示文摘 | Colombo A L Perfect J Di Nubile M | 2003 | Eur J Clin Microbiol Infect Dis2003，22，： | 1 |
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