|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | When sepsis affects the heart: A case report and literature review显示文摘A 59-year-old nursing home patient with Down syndrome was brought to the internal medicine department of our hospital due to fever, cough without expectorate, and dyspnea. A thoracic computed tomography revealed the presence of bilateral basal parenchymal opacities. Her condition deteriorated after admission and troponin reached a peak serum concentration of 16.9 ng/m L. The patient was in cardiogenic shock. In addition to fluid resuscitation, vaso-active amine infusion was administered to achieve hemodynamic stabilization. The differential diagnosis investigated possible pulmonary embolism, myocardial infarction, and myocarditis. Furthermore, a second transthoracic echocardiogram suggested Tako-Tsubo syndrome. This is a septic patient. The purpose of this manuscript is to review studies which formerly examined the possible association between high levels of troponin and mortality to see if it can be considered a positive predictive factor of fatal prognosis as the case of thrombocytopenia, already a positive independent predictive factor of multiple organ failure syndrome, and generally to characterize risk profile in a septic patient. | Giuseppe Clemente Antonino Tuttolomondo Daniela Colomba Rosaria Pecoraro Chiara Renda Vittoriano Della Corte Carlo Maida Irene Simonetta Antonio Pinto | 2015 | World Journal of Clinical Cases2015，3，8： | 5 |
| 2 | Transient elastography: A non-invasive tool for assessing liver fibrosis in HIV/HCV patients显示文摘AIM: To assess the prevalence of advanced liver fibrosis (ALF) in human immunodeficiency virus (HIV), hepatitis C virus (HCV) and HIV/HCV patients using transient elastography, and to identify factors associated with ALF. METHODS: Between September 2008 and October 2009, 71 HIV mono-infected, 57 HIV/HCV co-infected and 53 HCV mono-infected patients on regular follow-up at our Center were enrolled in this study. Alcohol intake, the main parameters of liver function, presence of HCV-RNA, HIV-RNA, duration of highly active anti-retroviraltherapy (HAART) and CD4 cell count were recorded. ALF was defined as liver stiffness (LS) ≥ 9.5 kPa. To estimate liver fibrosis (LF) a further 2 reliable biochemical scores, aspartate aminotransferase platelet ratio index (APRI) and FIB-4, were also used. RESULTS: LS values of co-infected patients were higher than in either HIV or HCV mono-infected patients (χ 2M H = 4, P < 0.04). In fact, LS ≥ 9.5 was significantly higher in co-infected than in HIV and HCV mono-infected pa-tients (χ 2 = 5, P < 0.03). Also APRI and the FIB-4 index showed more LF in co-infected than in HIV mono-infect-ed patients (P < 0.0001), but not in HCV mono-infected patients. In HIV?HCV co-infected patients, the extent of LS was significantly associated with alcohol intake (P < 0.04) and lower CD4+ cell count (P < 0.02). In HCV pa-tients, LS was correlated with alcohol intake (P < 0.001) and cholesterol levels (P < 0.03). Body mass index, dia-betes, HCV-and HIV-viremia were not significantly cor-related with LS. In addition, 20% of co-infected patients had virologically unsuccessful HAART; in 50% compliance was low, CD4+ levels were < 400 cells/mm 3 and LS was > 9.5 kPa. There was no significant correlation between extent of LF and HAART exposure or duration of HAART exposure, in particular with specific dideoxynucleoside analogues. CONCLUSION: ALF was more frequent in co-infected than mono-infected patients. This result correlated with lower CD4 levels. Protective immunological effects of HAART on LF progression outweigh its hepatotoxic effects. | Valentina Li Vecchi Maurizio Soresi Claudia Colomba Giovanni Mazzola Pietro Colletti Maurizio Mineo Paola Di Carlo Emanuele La Spada Giovanni Vizzini Giuseppe Montalto | 2010 | World Journal of Gastroenterology2010，16，41： | 4 |
| 3 | Role of the advanced glycation end products receptor in Crohn's disease inflammation显示文摘AIM:To investigate the level of mucosal expression and the involvement of the receptor for the advanced glycation end products(RAGE)in delayed apoptosis and tumor necrosis factor(TNF)-αproduction in Crohn’s disease(CD).METHODS:Surgical and endoscopic specimens from both inflamed and non-inflamed areas of the ileum and/or colon were collected from 20 and 14 adult CD patients,respectively,and used for the assessment of RAGE expression by means of immunohistochemistry and western blotting analysis.Normal tissues from 21 control subjects were used for comparison.The same polyclonal anti-human RAGE antibody(R and D System)was used in all experimental conditions.RAGE staining was quantized by a score including both the amount of positive cells and intensity of immunoreactivity;cellular pattern was also described.The effects of RAGE blocking on apoptotic rate and TNF-αproduction were investigated on immune cells freshly isolated from CD mucosa and incubated both with and without the muramyl dipeptide used as antigenic stimulus.Statistical analysis was performed via the test for trend,with regression models to account for intra-patient correlations.A 2-sided P<0.05 was considered significant.RESULTS:In inflamed areas,RAGE expression in both the epithelial and lamina propria compartments was higher than control tissues(P=0.001 and 0.021,respectively),and a cluster of positive cells were usually found in proximity of ulcerative lesions.Similar results were obtained in the lamina propria compartment of non-inflamed areas(P=0.025).The pattern of staining was membranous and granular cytosolic at the epithelial level,while in the lamina propria it was diffuse cytosolic.When evaluating the amount of protein expression by immunoblotting,a significant increase of both surface area and band intensity(P<0.0001 for both)was observed in CD inflamed areas compared to control tissue,while in non-inflamed areas a significant increase was found only for band intensity(P<0.005).Moreover,a significantly lower expression in noninflamed areas in comparison with inflamed areas was found for both surface area and band intensity(P<0.0006 for both).Finally,RAGE blocking largely affects both the apoptotic rate of mucosal cells(towards an increase in both non-inflamed and inflamed areas of P<0.001 and<0.0001,respectively)and TNF-αsecretion(towards a decrease in both non-inflamed and inflamed areas of P<0.05 and<0.01,respectively),mainly in the presence of antigenic stimulation.CONCLUSION:RAGE is up-regulated in CD,especially in inflamed areas,and it appears to play a role in the mechanisms involved in chronic inflammation. | Rachele Ciccocioppo Alessandro Vanoli Catherine Klersy Venerina Imbesi Vincenzo Boccaccio Rachele Manca Elena Betti Giuseppina Cristina Cangemi Elena Strada Roberta Besio Antonio Rossi Colomba Falcone Sandro Ardizzone Paolo Fociani Piergiorgio Danelli Gino Roberto Corazza | 2013 | World Journal of Gastroenterology2013，19，45： | 2 |
| 4 | Intrinsic kinetics of isothermal xylan degradation in inert atmosphere 显示文摘 | Colomba D B Lanzetta M | 1997 | Journal of Analytical and Applied Pyrolysis1997，，4041： | 1 |
| 5 | Chromosomal analysis of repeated DNAs in the rainbow wrasse Coris julis (Pisces, Labridae)显示文摘 | Mandrioli M Colomba M S Vitturi R | 2000 | Genetica2000，108，2： | 1 |
| 6 | Oxidation characteristics of chars generated from wood impregnated with (NH4)2HPO4 and (NH4)2 SO4显示文摘 | Carmen Branca Colomba Di Blasi | 2007 | The rmochimica Acta2007，456，2： | 1 |
| 7 | GC/MS characterization of liquids generated from low-temperature pyrolysis of wood显示文摘 | Carmen Branca Paola Giudicianni Colomba Di Blasi | | 0，，14： | 1 |
| 8 | Viral gastroenteritis in children hospitalised in Sicily, Italy显示文摘 | Colomba C De-Grazia S Giammanco GM | 2006 | Eur J Clin Microhiol Infect Dis2006，25，9： | 1 |
| 9 | Chromosomal location of ribosomal DNA (rDNA), ( GATA )n and ( TTAGGG )n telomeric repeats in the neogastropod Fasciolaria lignaria ( Mollusca:Prosobranchia) 显示文摘 | Vitturi R Colomba Gianguzza P | 2000 | Genetica2000，108，3： | 1 |
| 10 | The ' bystander effect': association of U-87 cell death with ganciclovir-mediated apoptosis of nearbycells and lack of effect in athymic mice显示文摘 | Bendettis S Ottolenghi S | 1995 | Human Gene Ther1995，6，： | 1 |
| 11 | Thermo-gravimetric analysis and devolatilization kinetics of wood显示文摘 | MORTEN G G GABOR V COLOMBA D B | 2002 | Ind Eng Chem Res2002，41，： | 1 |
| 12 | Modeling chemical and physical processes of wood and biomass pyrolysis显示文摘 | Colomba Di Blasi | 2008 | Progress in Energy and Combustion Science2008，34，： | 1 |
| 13 | Flame retarding of wood by impregnation with boric acid--Pyrolysis products and char oxidation rates显示文摘 | Colomba D B Carmen B Antonio G | 2007 | Polymer Degradation and Stability2007，92，： | 1 |
| 14 | Modeling and simulation of combustion processes of charring and non-charring solid fuels 显示文摘 | COLOMBA D B | 1993 | Progress Energy Combustion Science1993，19，： | 1 |
| 15 | Flame retarding of wood by impregnation with boric acid-pyrolysis products and char oxida- tion rates显示文摘 | COLOMBA D B CARMEN B ANTONIO G | 2007 | Polymer Degradation and Stability2007，92，5： | 1 |
| 16 | Influences of sample thickness on the early transient stages of concurrent flame spread and solid buming显示文摘 | Colomba D B | 1995 | Fire Safety Journal1995，25，4： | 1 |
| 17 | Devolatilization in the temperature range 300-600K of liquids derived from wood pyrolysis and gasification显示文摘 | Carmen Branea Colomba Di Blasi Carmine Russo | 2005 | Fuel2005，84，1： | 1 |
| 18 | Dynamic behaviour of stratified downdraft gasifiers显示文摘 | Blasi Colomba Di | | 0，，15： | 1 |
| 19 | Dynamic behaviour of strati'ed downdraft gasi'ers显示文摘 | Blasi Colomba Di | 2000 | Chemical EngineeringScience2000，，55： | 1 |
| 20 | Soluble receptor for advanced glyeation end products: from disease marker to potential therapeutic target 显示文摘 | Diego G Colomba F Enzo E | 2006 | Curr Med Chem2006，13，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员