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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 3 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 4 | The modified compression-field theory for reinforced concrete elements subjected to shear 显示文摘 | Vecchio F J Collins M P | 1986 | ACI Structural Journal1986，83，2： | 2 |
| 5 | Extreme oxygen sensitivity of electronic properties of carbon nanotubes 显示文摘 | Collins P G Bradley K Ishigami M | 2000 | Science2000，287，： | 2 |
| 6 | Hidden risks associated with conventional short intermittent hemodialysis:A call for action to mitigate cardiovascular risk and morbidity显示文摘The development of maintenance hemodialysis(HD)for end stage kidney disease patients is a success story that continues to save many lives.Nevertheless,intermittent renal replacement therapy is also a source of recurrent stress for patients.Conventional thrice weekly short HD is an imperfect treatment that only partially corrects uremic abnormalities,increases cardiovascular risk,and exacerbates disease burden.Altering cycles of fluid loading associated with cardiac stretching(interdialytic phase)and then fluid unloading(intradialytic phase)likely contribute to cardiac and vascular damage.This unphysiologic treatment profile combined with cyclic disturbances including osmotic and electrolytic shifts may contribute to morbidity in dialysis patients and augment the health burdenof treatment. As such, HD patients are exposed to multiple stressors including cardiocirculatory,inflammatory, biologic, hypoxemic, and nutritional. This cascade of events can be termed thedialysis stress storm and sickness syndrome. Mitigating cardiovascular risk and morbidityassociated with conventional intermittent HD appears to be a priority for improving patientexperience and reducing disease burden. In this in-depth review, we summarize the hidden effectsof intermittent HD therapy, and call for action to improve delivered HD and develop treatmentschedules that are better tolerated and associated with fewer adverse effects. | Bernard Canaud Jeroen P Kooman Nicholas M Selby Maarten Taal Andreas Maierhofer Pascal Kopperschmidt Susan Francis Allan Collins Peter Kotanko | 2022 | World Journal of Nephrology2022，11，2： | 2 |
| 7 | Strut-and-tie models for design of pile caps: an experimental study 显示文摘 | Adebar P Kuchma D Collins M P | 1992 | ACI Structural Journal1992，87，1： | 1 |
| 8 | The modified compression field theory for reinforced concrete elements subjected to shear 显示文摘 | Vecchio F J Collins M P | 1986 | ACI Journal1986，83，2： | 1 |
| 9 | The modified compression-filed theory for reinforced concrete elements subjected to shear显示文摘 | Vecchio F J and Collins M P | | ACI Struct J0，83，2： | 1 |
| 10 | A method for determining optimum sample size in species diversity studies显示文摘 | De Caprariis P Lindemann R H Collins C M | 1976 | Mathematical Geology1976，8，5： | 1 |
| 11 | High incidence of micrometastasesin breast cancer sentinel nodes 显示文摘 | Mann B G Buchana M Collins P J | 2000 | Aust N ZJ Surg2000，70，： | 1 |
| 12 | Simplified modi- fied compression field theory for calculating shear strength of reinforced concrete elements 显示文摘 | Bentz E C Vecehio F J Collins M P | 2006 | ACI Structural Journal2006，103，4： | 1 |
| 13 | Which Ore field signs/symptoms predict protracted recovery from sport- related concussion among high school football players? 显示文摘 | LAU B C KONTOS A P COLLINS M W | 2011 | Am J Sports Med2011，39，11： | 1 |
| 14 | Predicting the response of reinforced concrete beams subjected to shear using modified compression field theory 显示文摘 | Vecchio F J Collins M P | 1988 | ACI Structural Journal1988，85，3： | 1 |
| 15 | The modified compression-field theory for reinforced concrete elements subjected to shear显示文摘 | Vecchio F J Collins M P | 1986 | ACI1986，83，2： | 1 |
| 16 | The phylogeny of the genus Clostridium: proposal of five new genera and eleven new species eombinations显示文摘 | COLLINS M D LAWSON P A WILLEMS A | 1994 | Int J Syst Baeteriol1994，44，4： | 1 |
| 17 | Effect of Concrete Strength and Minimum Stirrups on Shear Strength Large Members显示文摘 | ANGELAKOS D BENTZ E C COLLINS M P | 2001 | ACI Structural Journal2001，98，3： | 1 |
| 18 | Oxidation of anthracene and benzo pyrene by laccases from Trametes versicolor 显示文摘 | COLLINS P J KOTTERMAN M J J FIELD J A | 1996 | Appl Environ Microbiol1996，62，12： | 1 |
| 19 | The effect of betablocker premedication on the surgical field during endoscopic sinus surgery 显示文摘 | Nair S Collins M Hung P | 2004 | Laryngoscope2004，114，6： | 1 |
| 20 | How safe are our large,lightly reinforced concrete beams,slabs and footings显示文摘 | COLLINS M P KUCHMA D | 1999 | ACI Structural Journal1999，96，4： | 1 |
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