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| 1 | 抗生素耐药性环境中产生和转移的人类健康风险评估(HHRA)显示文摘[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性病原体所致的抗生素治疗失败中所起的作用。[方法]作者参加了2012年3月4—8日在加拿大魁北克省举行的研讨会,定义抗生素耐药性风险与人类健康环境评估的范围和目标。我们专注于环境中耐药性产生'热点区域'的关键要素,(与食品无关的)暴露评估以及剂量反应,以描述风险特征,从而改善抗生素耐药性管理的方案。[讨论]识别传统风险评估中有助于评估环境中抗生素耐药性的各个新方面。包括:a)解释附加的选择压力对环境耐药基因组的作用,即随着时间的推移,促使抗生素耐药性细菌(ARB)产生;b)在相关的环境组成部分的'热点区域'中识别和描述水平基因转移(HGT)率;c)针对不同健康结局和途径的ARB剂量修改传统的剂量反应方法。[结论]我们建议将抗生素耐药性产生造成的环境影响纳入所有涉及ARB的HHRA过程之中。由于可用的数据有限,一种多标准决策分析方法将有助于进行环境中抗生素耐药性的HHRA,并使风险管理者了解环境抗生素耐药性。 | Nicholas J.Ashbolt Alejandro Amézquita Thomas Backhaus Peter Borriello Kristian K.Brandt Peter Collignon Anja Coors Rita Finley William H.Gaze Thomas Heberer John R.Lawrence D.G.Joakim Larsson Scott A.McEwen James J.Ryan Jens Schnfeld Peter Silley Jason R.Snape Christel Van den Eede Edward Topp 王晓宇 张伊人 操仪 | 2014 | 环境与职业医学2014，31，2： | 3 |
| 2 | Multimodality image registration by maximization of mutual information 显示文摘 | Maes F Collignon A Vandermeulen D | 1997 | IEEE Transactions on Medical Imaging1997，16，2： | 2 |
| 3 | Multimodality image registration by maximization of mutual information显示文摘 | Collignon A Vandermelen D | 1997 | IEEE Transactions on Medical Imaging1997，16，2： | 1 |
| 4 | Multimodality image registration by maximization of mutual information显示文摘 | Maes F Collignon A Vandermeulen D | 1997 | IEEE Trans Med Imag1997，16，4： | 1 |
| 5 | Fusidic acid in vitro activity显示文摘 | Collignon P Turndge J | 1999 | Int J Antimicrob Agents1999，12，2： | 1 |
| 6 | A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2 显示文摘 | Collignon J Sockanathan S Norris D | 1996 | Development1996，122，2： | 1 |
| 7 | A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes显示文摘 | GUBBAY J COLLIGNON J KOOPMAN P | 1990 | Nature1990，346，346： | 1 |
| 8 | Multi-modality image registration by maximization of mutual information显示文摘 | Collignon A Vandermeulen D | 1997 | IEEE Transactions on Medical Imaging1997，16，2： | 1 |
| 9 | A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes显示文摘 | GUBBAY J COLLIGNON J KOOPMAN D | 1990 | Nature1990，346，： | 1 |
| 10 | Multimodality image registration by maximization of mutual information显示文摘 | Maes F Collignon A Vandermeulen D | 1997 | IEEE Trans Med Imag1997，16，2： | 1 |
| 11 | Multimodality image registration by maximization of mutual information显示文摘 | Maes F Collignon A Vandermeulen D | 1997 | IEEE Trans Med Image1997，16，2： | 1 |
| 12 | lsolation of cells from ovine fetal long bone and characterization of their osteoblastic antivities during in vitro mineralization显示文摘 | Collignon H Davicco M J Barlet J P | 1997 | Arch Physiol Biochem1997，105，2： | 1 |
| 13 | Multi- modality image registration by maximization of mu- tual information显示文摘 | Maes F Collignon A Vandermeulen D | 1997 | IEEE Transactions on Medical Imaging1997，，16： | 1 |
| 14 | Involvement of Sox1, 2 and 3 in the early and subsequent molecular events of lens induction显示文摘 | Kamachi Y Uchikawa M Collignon J | 1998 | Development1998，25，： | 1 |
| 15 | Nonlesional central lobule seizures: use of awake cortial mapping and subdural grid monitoring for resection of seizure focus显示文摘 | Cohen-Gadol AA Britton JW Collignon FP | 2003 | J Neurosurg2003，98，： | 1 |
| 16 | Systemic sepsis and intra venous devices ,a prospective survey显示文摘 | Collignon PJ Munro R Sorrell TC | 1984 | Med J Aust1984，141，6： | 1 |
| 17 | Multimodality image registration by maximization of mutual information显示文摘 | Maes F Collignon A Vandermeulen D | 1997 | IEEE Transactions on Medical Imaging1997，16，2： | 1 |
| 18 | Sixty-four-row multisection CT angiography for detection and evaluation of ruptured intracranial aneurysms:interobserver and intertechnique reproducibility显示文摘 | Lubicz B Levivier M Franois O Thoma P Sadeghi N Collignon L | 2007 | AJNR Am J Neuroradiol2007，28，： | 1 |
| 19 | Multimodality image registration by maximization of mutual information显示文摘 | Maes F Collignon A Vandermeulen D | 1997 | IEEE Trans on Medical Imaging1997，16，2： | 1 |
| 20 | Multimodality Image Registration by Maximization of Mutual Information显示文摘 | Maes F Collignon A Vandermeulen D | 1997 | IEEE Transactions on Medical Imaging1997，16，2： | 1 |
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