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| 1 | Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients显示文摘AIM To investigate the relationships among diverse metalloproteases(MMPs) and their tissue inhibitors(TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus(HIV)-infected patients.METHODS Single nucleotide polymorphisms(SNPs) in MMPs, TNF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus(HCV) coinfection. A total of 158 patients were included, 57 of whom were HCVcoinfected. All patients drank < 50 g ethanol/day. Diverse SNPs(MMP-1-1607 1G/2G, MMP-8-799C/T, MMP-9-1562 C/T, MMP-13-77A/G, TNF-α-308 G/A,CCR5-?32), and serum levels of MMPs(2, 3, 8, 9 and 10) and TIMPs(1, 2 and 4) were assessed. Liver fibrosis was determined by transient elastometry, although other non-invasive markers of fibrosis were also considered. Significant liver fibrosis(F ≥ 2) was defined by a transient elastometry value ≥ 7.1 kP a.RESULTS A total of 34 patients(21.5%) had liver fibrosis ≥ F2. MMP-2 and TIMP-2 serum levels were higher in patients with liver fibrosis ≥ F2(P = 0.02 and P = 0.03, respectively) and correlated positively with transient elastometry values(P = 0.02 and P = 0.0009, respectively), whereas MMP-9 values were negatively correlated with transient elastometry measurements(P = 0.01). Multivariate analyses showed that high levels of MMP-2(OR = 2.397; 95%CI: 1.191-4.827, P = 0.014) were independently associated with liver fibrosis ≥ F2 in the patients as a whole. MMP-2(OR = 7.179; 95%CI: 1.210-42.581, P = 0.03) and male gender(OR = 10.040; 95%CI: 1.621-62.11, P = 0.013) were also independent predictors of fibrosis ≥ F2 in the HCV-infected subgroup. Likewise, MMP-2, TIMP-2 and MMP-9 were independently associated with transient elastometry values and other non-invasive markers of liver fibrosis. None of the six SNPs evaluated had any significant association with liver fibrosis ≥ F2.CONCLUSION Certain MMPs and TIMPs, particularly MMP-2, seems to be associated with non-alcoholic liver fibrosis in HIVinfected patients with/without HCV coinfection. | Julio Collazos Eulalia Valle-Garay Tomás Suárez-Zarracina Angel-Hugo Montes José A Cartón Víctor Asensi | 2017 | World Journal of Virology2017，6，2： | 3 |
| 2 | Portfolio selection with skewness in emerging market industries 显示文摘 | Canela M A Collazo E P | 2007 | Emerging Markets Review2007，8，3： | 1 |
| 3 | Seasonal variation in haematological parameters in male and female Tinca tinca显示文摘 | María Eugenia Collazos Eduardo Ortega Carmen Barriga Ana Beatriz Rodrìguez | 1998 | Molecular and Cellular Biochemistry (-)1998，，1： | 1 |
| 4 | Characterisation of barrier properties of organic paints : the zinc phosphate effectiveness显示文摘 | M BEINENCOURT A COLLAZO M LZQUIERDO | 2003 | Progress in Organic Coatings2003，46，5： | 1 |
| 5 | Corrosion protection performance of sol-gel coatings doped with red mud applied on AA2024-T3 显示文摘 | COLLAZO A COVELO A NOVOA X R PEREZ C | 2012 | Progress in Organic Coatings2012，74，2： | 1 |
| 6 | Hot electron transport in AIN显示文摘 | Collazo R Schlesser R Roskowski A | 2000 | J Appl Phys2000，88，10： | 1 |
| 7 | Accessible habitat for shorebirds: Factors influencing its availability and conservation implications显示文摘 | COLLAZO J A O'HARRA D A KELLY C A | 2002 | Waterbirds2002，25，2： | 1 |
| 8 | Seasonal variation in haematological parameters in male and female Tinca tinca显示文摘 | Collazos M E Ortega E Barriga C Rodriguz A B | 1998 | Molecular and Cellular Biochemistry1998，183，： | 1 |
| 9 | Corrosion behavior of cermet coatings in artifical seawater显示文摘 | Collazo A Novoa X R Perez C | 1999 | Electrochimica Acta1999，，44： | 1 |
| 10 | CA19-9 in non-neoplastic liver diseases: A clinical and laboratory, study显示文摘 | Collazos J Genolla J Ruibal A | 1992 | Clin Chim Acta1992，210，2： | 1 |
| 11 | Serum levels of CA50 in nonmalignant liver disease:A clinical and biochemical study显示文摘 | Collazos J Genolla J Ruibal A | 1993 | Am J Gastroenterol1993，88，3： | 1 |
| 12 | Serum levels of CA50 in nonmalignant liver diseases:A clinical and biochemical study显示文摘 | Collazos J Genolla J Ruibal A | 1993 | Amer J Gastroenterol1993，88，3： | 1 |
| 13 | Cul- tural competency training in psychiatry显示文摘 | Qureshi A Collazos F Ramos M | 2008 | Eur Psychiatry2008，23，： | 1 |
| 14 | EIS study for the rust converter effectiveness under different conditions显示文摘 | Collazo A Novoa X R Perez C Puga B | 2008 | Electrochimica Acta2008，53，： | 1 |
| 15 | Characterisation of the barrier properties of different paint systems Part Ⅰ : Experimental set-up and ideal Fickian diffusion显示文摘 | Perez C Collazo A Izquierdo M | 1999 | Progress in Organic Coatings1999，，36： | 1 |
| 16 | Charaeterisation of the barrier properties of different paint systems Part Ⅱ :Non-ideal differsion and water uptake kineties显示文摘 | Perez C Collazo A Izquierdo M | 1999 | Progress in Organie Coatings1999，，37： | 1 |
| 17 | Regulatory mycluid sup- pressor cells in heahh and disease 显示文摘 | Nagaraj S Collazo M Corzo C A | 2009 | Cancer Res2009，69，19： | 1 |
| 18 | Prevalence and se- rovars of Salmonella enteric a on pig carcasses* slaughtered pigs and the environment of four Spanish slaughterhouses显示文摘 | Arguello H Carvajal A Collazos J A | 2012 | Food Res Int2012，45，2： | 1 |
| 19 | Idiopathic pulmonary hemosiderosis; long-term follow-up in 10 patients treated with corticoids and immunosuppressive agents显示文摘 | Ceruti Danus E Casar Collazo C Diaz Cruz A | 1980 | Bol Med Hosp Infant Mex1980，37，5： | 1 |
| 20 | Corrosion behavior of cermet coatings in artifical seawater显示文摘 | Collazo A Novoa X R Perez C | 1999 | Electrochimica Acta1999，44，24： | 1 |
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