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| 1 | Probiotic bacteria change Escherichia coli-induced gene expression in cultured colonocytes:Implications in intestinal pathophysiology显示文摘AIM: To investigate the change in eukaryotic gene expression profile in Caco-2 cells after infection with strains of Escherichia coli and commensal probiotic bacteria. METHODS: A 19 200 gene/expressed sequence tag gene chip was used to examine expression of genes after infection of Caco-2 cells with strains of normal flora E. coli,Lactobacillus plantarum,and a combination of the two. RESULTS: The cDNA microarray revealed up-regulation of 155 and down-regulation of 177 genes by E. coli . L. plantarum up-regulated 45 and down-regulated 36 genes. During mixed infection,27 genes were up-regulated and 59 were down-regulated,with nullification of stimulatory/inhibitory effects on most of the genes. Expression of several new genes was noted in this group. CONCLUSION: The commensal bacterial strains used in this study induced the expression of a large number of genes in colonocyte-like cultured cells and changed the expression of several genes involved in important cellular processes such as regulation of transcription,protein biosynthesis,metabolism,cell adhesion,ubiquitination,and apoptosis. Such changes induced by the presence of probiotic bacteria may shape the physiologic and pathologic responses they trigger in the host. | Pinaki Panigrahi Gheorghe T Braileanu Hegang Chen O Colin Stine | 2007 | World Journal of Gastroenterology2007，13，47： | 10 |
| 2 | Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart显示文摘出生后的心通过 hypertrophic 生长适应应力和超载,可能病理学或有益的一个过程(生理的肥大) 。生理的肥大改进心脏的性能在健康并且 diseased 个人,然而,宣传这有利改编的机制仍然保持糟糕定义。我们识别 cytokine cardiotrophin (CT1 ) 1 作为能够包括导致的导出 cardiomyocyte 的 angiogenic 信号的心肌层,和刺激的短暂、可逆的肥大概括心的生理的生长的特色的一个因素增加了由脉管形成。CT1 的能力从 caspase 激活的调停 CK2 的制止发源导致生理的肥大,阻止到无限制的病理学的生长的转变。外长的 CT1 蛋白质交货稀释了病理并且在正确的心失败的一个严格的模型恢复了可收缩的功能,建议为这难处理的心脏病的一种新奇处理选择。 | Mohammad Abdul-Ghani Colin Suen Baohua Jiang Yupu Deng Jonathan J Weldrick Charis Putinski Steve Brunette Pasan Femando Tom T Lee Peter Flynn Frans H H Leenen Patrick G Burgon Duncan J Stewar Lynn A Megeney | 2017 | Cell Research2017，27，10： | 8 |
| 3 | Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data显示文摘 | Alan D Lopez Colin D Mathers Majid Ezzati Dean T Jamison Christopher JL Murray | 2006 | The Lancet . 2006 (9524)2006，，9524： | 2 |
| 4 | Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data显示文摘 | Alan D Lopez Colin D Mathers Majid Ezzati Dean T Jamison Christopher JL Murray | 2006 | 2006 (9524)2006，，9524： | 2 |
| 5 | A multiscale mathematical model of canc-er,and its use in analyzing irradiation therapies显示文摘 | Ribba B Colin T Schnell S | | 0，，07： | 1 |
| 6 | Longitudinal study of children with perinatal braindamage in whom early neurohabilitation was applied: Pre- liminary report显示文摘 | Harmony T Barrera Resendiz J Juarez Colin M E | 2015 | Neurosci Lett2015，611，： | 1 |
| 7 | Numerical methods for unsteady compressible multi-component reacting flows on fixed and moving grids 显示文摘 | MOUREAU V LARTIGUE G SOMMERER Y ANGELBERGER C COLIN O POINSOT T | 2005 | Journal of Computational Physics2005，202，2： | 1 |
| 8 | Degradation of lambda-carrageenan by Pseudoalteromonas carrageenovora lambda-carrageenase: a new family of glycoside hydrolases unrelated to kappa-and iota-carrageenases显示文摘 | Guibet M Colin S Barbeyron T | 2007 | Biochem J2007，404，1： | 1 |
| 9 | On the Cauchy problem for a nonlocal nonlinear Schrodinger equation occur- ring in plasma physics 显示文摘 | Colin T | 1993 | Differential Integral Equations1993，6，： | 1 |
| 10 | Semimonthly versus monthly regimen of fluorouracil and leucovorin administered for 24 or 36 weeks as adjuvant therapy in stage Ⅱ and Ⅲ colon cancer:results of a randomized trial显示文摘 | Andre T Colin P Louver C | 2003 | J Clin Oncol2003，21，15： | 1 |
| 11 | AsFabricated and HeatTreated Microstructures of the Ti6A14V Alloy Processed by Selective Laser Melting显示文摘 | Vilaro T Colin C Bartout J D | 2011 | Metallurgical and Materials Transactions A2011，42，10： | 1 |
| 12 | Detrital fine grained sediment contribution from Taiwan to the northern South China Sea and its relation to regional ocean cireulation显示文摘 | LIU Z F TUO S T COLIN C | 2008 | Marine Geology2008，255，： | 1 |
| 13 | Distribution system planning in focus显示文摘 | Ault Graham W Foote Colin E T Mcdonald James R | 2002 | IEEE Power Engineering Review2002，22，1： | 1 |
| 14 | A systematic review and me-ta-analysis of clinicopathologic factors linked to intravesical recur-rence after radical nephroureterectomy to treat upper tract urothelialcarcinoma 显示文摘 | Seisen T Granger B Colin P | 2015 | Eur Urol2015，67，6： | 1 |
| 15 | Water stress and CO2 exchange rate of pitahaya(Hylocereus undatus) 显示文摘 | ORTIZH Y D LIVERA M M COLIN AS L T | 1999 | Agrociencia1999，33，： | 1 |
| 16 | Prospective identification of tumorigenic prostate cancer stem cells显示文摘 | Colins A T Berry P A Hyde C | 2005 | Cancer Res2005，65，10： | 1 |
| 17 | Methods for the evaluation of the maturity of municipal refuse compost显示文摘 | Morel T L Colin F Germon J | 1985 | Composting of Agricultural and Other Wastes1985，5672，： | 1 |
| 18 | Impact of cattle on soil physical properties and nutrient concentrations in overland flow from pasture in Ireland显示文摘 | Isabelle K Colin D R Hubert T | 2006 | Agriculture Ecosystems and Environment2006，113，： | 1 |
| 19 | An error correction model of induced innovation in UK agriculture 显示文摘 | Jenifer P David S Colin T | 2011 | Applied Economics2011，43，1： | 1 |
| 20 | Microstructural and me- chanical approaches of the selective laser melting process applied to a nickel-base superalloy 显示文摘 | Vilaro T Colin C Bartout J D | 2012 | Materials Science and Engineer- ing: A2012，534，2： | 1 |
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