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| 1 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 2 | Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group 显示文摘 | Husain A N Colby T V Ordonez N G | 2009 | Arch Pathol Lab Med2009，133，8： | 1 |
| 3 | Nonspecific interstitial pneumonia: correlation between thin-section CT findings and pathologic subgroups in 55 patients 显示文摘 | Johkoh T Muller NL Colby TV | 2002 | Radiology2002，225，1： | 1 |
| 4 | Lung nodule enhancement at CT:prospective findings 显示文摘 | Swensen S J Brown L R Colby T V | 1996 | Radiology1996，201，2： | 1 |
| 5 | Synthesis and characterization of long chain branched isotactic polypropylene via metallocene catalyst and T-reagent 显示文摘 | Langston J A Colby R H Chung T C M | 2007 | Macromolecules2007，40，8： | 1 |
| 6 | The new world health organization classification of lung tumours 显示文摘 | Brambilla E Travis W D Colby T V | 2001 | Europ Respirat J2001，18，6： | 1 |
| 7 | Pulmonary nodules:CT evaluation of enhancement with iodinated contrast material显示文摘 | Swensen S J Brown L R Colby T V | 1995 | Radiology1995，，： | 1 |
| 8 | A reference map of the Arabidopsis thaliana mature pollen proteome 显示文摘 | NOIR D BRAUTIGAM A COLBY T | 2005 | Biochem Bioph Res Co2005，337，4： | 1 |
| 9 | Nonspecific interstitial pneumonia: correlation between thin-section CT findings and pathological subgroups in 55 patients显示文摘 | Johkoh T Müller NL Colby TV | 2002 | Radiology2002，225，1： | 1 |
| 10 | A comparison of knee joint motion pattems between men and women in selected athletic tasks显示文摘 | Malinzak R A Colby S M Kirkendall D T | 2001 | Clinical Biomechanics2001，16，5： | 1 |
| 11 | Lymphoid hyperplasia and eosinophilic pneumonia as histologic manifestations of amiodarone- induced lung toxicity显示文摘 | Larsen B T Vaszar L T Colby T V | 2012 | Test Site2012，36，4： | 1 |
| 12 | Bronchiolitis obliterans organizing pneumonia显示文摘 | Epler G R Colby T V McLoud T C | 1985 | N Engl J Med1985，312，3： | 1 |
| 13 | Synthesis and Characterization of Long Chain Branched Isotactic Poly- propylene via Metalloeene Catalyst and T-Reagent显示文摘 | Langston J A Colby R H Chung T C M | 2007 | Macro- molecules2007，40，8： | 1 |
| 14 | Thoracic lymphangiomas,lymphangiectasis,lymphangiomatosis,and lymphatic dysplasia syndrome显示文摘 | Faul J L Berry G J Colby T V | 2000 | Am J Respir Crit Care Med2000，161，31： | 1 |
| 15 | Bronchiolitis obliterans organizing pneumonia显示文摘 | Epler G R Colby T V Mcloud T C | 1985 | N Engl Med1985，312，： | 1 |
| 16 | Large-scale pro-teomic analysis of the grapevine leaf apoplastic fluid reveals mainlystress-related proteins and cell wall modifying enzymes 显示文摘 | DELAUNOIS B COLBY T BELLOY N | 2013 | BMCPlant Biology2013，13，： | 1 |
| 17 | Idiopathic interstitial pneumonias:high-resolution CT and histologic findings 显示文摘 | Mullar N L Colby T V | 1997 | Radiographics1997，17，： | 1 |
| 18 | Lymphoid hyperplasia and eosinophilic pneumonia as histologic manifestations of amiodarone-induced lung toxicity显示文摘 | Larsen B T Vaszar L T Colby T V | 2012 | Test Site2012，36，4： | 1 |
| 19 | Guidelines forpathologic diagnosis of malignant mesothelioma : 2012update of the consensus statement from the internationalmesothelioma interest group 显示文摘 | Husain A N Colby T Ordonez N | 2013 | Archives of Pathology& Laboratory Medicine2013，137，5： | 1 |
| 20 | The human erythrocyte infllammatory peptide (chemokine) receptor, biochemical characterization, solubilization and deveopment of a binding assay for the souble receptor显示文摘 | Horuk R Colby T J Darbornne W C | 1993 | Biochem1993，32，22： | 1 |
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