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| 1 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 2 | Functional ex- pression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells显示文摘 | Chambers I Colby D Robertson M | 2003 | Ce112003，113，5： | 1 |
| 3 | Functional expression cloning of Nanog:a pluripoteney sustaining factor in embryonic stem cells显示文摘 | Chambers I Colby D Robertson M | 2003 | Cell2003，113，5： | 1 |
| 4 | Synthesis and characterization of long chain branched isotactic polypropylene via metallocene catalyst and T-reagent 显示文摘 | Langston J A Colby R H Chung T C M | 2007 | Macromolecules2007，40，8： | 1 |
| 5 | Functional expressioncloning of Nanog,a pluripotency sustaining factor in embryonicstem cells显示文摘 | Chambers I Colby D Robertson M | 2003 | Cell2003，113，5： | 1 |
| 6 | CDX-2 homeobox gene expression is a reliable marker of colorectal adenocarcinoma metastases to the lungs显示文摘 | Barbareschi M Murer B Colby TV | 2003 | Am J Surg Pathol2003，27，： | 1 |
| 7 | Functional expression cloning of nanog,a phripotency sustaining factor in embryonic stem cells显示文摘 | Chambers I Colby D Robertson M | 2003 | Cell2003，113，： | 1 |
| 8 | Functional expression cloning of nanog, a pluripotency sustaining factor in embryonic stem cells显示文摘 | Chambers I Colby D Robertson M | 2003 | Cell2003，113，： | 1 |
| 9 | Yield of orchard grass as influenced by rates of nitrogen and harvest management显示文摘 | Drake M Colby W G Bredakis E | 1963 | Agronomy Journal1963，55，： | 1 |
| 10 | Effect of feeding high levels of protein and calcium in rat rations on magnesium defieieney syndrome显示文摘 | COLBY R W FRYE C M | 1951 | American Journal of Physiology1951，166，： | 1 |
| 11 | Nonspecific interstitial pneumonia: correlation between thin-section CT findings and pathological subgroups in 55 patients显示文摘 | Johkoh T Müller NL Colby TV | 2002 | Radiology2002，225，1： | 1 |
| 12 | 100 W Operation of a Cold Cathode TWT显示文摘 | Whaley David R Armstrong Carter M Bellew Colby L | | 0，，05： | 1 |
| 13 | A comparison of knee joint motion pattems between men and women in selected athletic tasks显示文摘 | Malinzak R A Colby S M Kirkendall D T | 2001 | Clinical Biomechanics2001，16，5： | 1 |
| 14 | Functional expression cloning of Nanog,a pluripoteney sustaining factor in embryonic stem cells显示文摘 | CHAMBERS I COLBY D ROBERTSON M | 2003 | Cell2003，113，5： | 1 |
| 15 | Synthesis and Characterization of Long Chain Branched Isotactic Poly- propylene via Metalloeene Catalyst and T-Reagent显示文摘 | Langston J A Colby R H Chung T C M | 2007 | Macro- molecules2007，40，8： | 1 |
| 16 | Correlations of solution rheology with electrospun fiber formation of linear and branched polyesters 显示文摘 | McKee M G Wilkes G L Colby R H | 2004 | Macromolecules2004，37，： | 1 |
| 17 | Recruitment of larval fishes into a north carolina estuary during a bloom of the red tide dinoflagellate,Gymnodinium breve显示文摘 | Warlen S M Tester P A Colby D R | 1998 | Bulletin of Marine Science1998，63，1： | 1 |
| 18 | Remote sensing and geomorphometry for studying relief production in high mountains 显示文摘 | BISHOP M P SHRODER JR J F COLBY J D | 2003 | Geomorphology2003，55，： | 1 |
| 19 | Protection against infection and abortion induced by virulent Challenge exposure after oral vaccination of Cattle with Brucella abortus strain RB51显示文摘 | Philip H E Fred M E Colby L | 1998 | AJNR1998，59，12： | 1 |
| 20 | Induc- ible, brain region-specific expression of a dominant nega- tive mutant of c-Junin transgenic mice decreases sensitivi- ty to cocaine显示文摘 | PEAKMAN M C COLBY C PERROTYI L I | 2003 | Brain Res2003，970，2： | 1 |
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