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| 1 | Pelvic exenterations for primary rectal cancer:Analysis from a 10-year national prospective database显示文摘AIM To identify short-term and oncologic outcomes of pelvic exenterations(PE) for locally advanced primary rectal cancer(LAPRC) in patients included in a national prospective database.METHODS Few studies report on PE in patients with LAPRC. For this study, we included PE for LAPRC performed between 2006 and 2017, as available, from the Rectal Cancer Registry of the Spanish Association of Surgeons [Asociación Espa?ola de Cirujanos(AEC)]. Primary endpoints included procedure-associated complications, 5-year local recurrence(LR), disease-free survival(DFS) and overall survival(OS). A propensitymatched comparison with patients who underwent non-exenterative surgery for low rectal cancers was performed as a secondary endpoint.RESULTS Eight-two patients were included. The mean age was 61.8 ± 11.5 years. More than half of the patients experienced at least one complication. Surgical site infections were the most common complication(abdominal wound 18.3%, perineal closure 19.4%). Thirty-three multivisceral resections were performed, including two hepatectomies and four metastasectomies. The long-term outcomes of the 64 patients operated on before 2013 were assessed. The five-year LR was 15.6%, the distant recurrence rate was 21.9%, and OS was 67.2%, with a mean survival of 43.8 mo. R+ve resection increased LR [hazard ratio(HR) = 5.58, 95%CI: 1.04-30.07, P = 0.04]. The quality of the mesorectum was associated with DFS. Perioperative complications were independent predictors of shorter survival(HR = 3.53, 95%CI: 1.12-10.94, P = 0.03). In the propensity-matched analysis, PE was associated with better quality of the specimen and tended to achieve lower LR with similar OS.CONCLUSION PE is an extensive procedure, justified if disease-free margins can be obtained. Further studies should define indications, accreditation policy, and quality of life in LAPRC. | Gianluca Pellino Sebastiano Biondo Antonio Codina Cazador JoséMaría Enríquez-Navascues Eloy Espín-Basany Jose Vicente Roig-Vila Eduardo García-Granero | 2018 | World Journal of Gastroenterology2018，24，45： | 1 |
| 2 | Long-term functional results from a randomized clinical study of transverse coloplasty compared with colon J-pouch after low anterior resection for rectal cancer 显示文摘 | Biondo S Frago R Codina Cazador A | 2013 | Surgery2013，153，： | 1 |
| 3 | Transforming carbonic anhydrase into epoxide synthase by metal exchange 显示文摘 | Femandez-Gacio A Codina A Fastrez J | 2006 | Chembiochem2006，7，7： | 1 |
| 4 | Long-term functional results from a randomized clinical study of transverse coloplasty compared with colon J-pouch after low anterior resection for rectal cancer 显示文摘 | Biondo S Frago R Codina Cazador A | 2013 | Surgery2013，153，： | 1 |
| 5 | Dysphagia due to Chiari Ⅰ malformation mimicking ALS 显示文摘 | Gamez J Santamarina E Codina A | 2003 | J Neural Neurosurg Psychiatry2003，74，4： | 1 |
| 6 | Scale-up studies of an Fe/Cr redox flow battery based on shunt current analysis显示文摘 | Codina G Aldaz A | 1992 | Journal of Applied Electrochemistry1992，22，7： | 1 |
| 7 | Cytochrome c-induced lymphocyte death from the outside in:inhibition by serum leucine-rich alpha-2-glycoprotein-1显示文摘 | Codina R Vanasse A Kelekar A | 2010 | Apoptosis2010，15，2： | 1 |
| 8 | Gallstone ileus:results of analysis of a series of 40 patients显示文摘 | Rodriguze Hermosa JI Codina Cazadir A Gorones Vila J | 2001 | Gastroenteral Hepatol2001，24，10： | 1 |
| 9 | Scaleup studies of an Fe/Cr redox flow battery based on shunt current analysis显示文摘 | Codina G Aldaz A | 1992 | J Appl Electro- chem1992，22，7： | 1 |
| 10 | Reeonstitution of somatostatin and muscarinic receptor mediated stimulation of K ~ channels by isolated GK protein in clonal rat anterior pituitary cell membranes 显示文摘 | Yatani A Codina J Sekura RD | 1987 | Mol Endocrinol1987，1，4： | 1 |
| 11 | Gallstone Ileus:results of analysis of a series of 40 patients显示文摘 | Rodriguez Hermosa JI Codina Cazador A | 2001 | Gastroenterol Hepatol2001，24，10： | 1 |
| 12 | Comparative st- udy of the effect of low-dosage acetylsalicylic acid and tri- flusal in the prevention of cardiovascular events among young adults with ischemic cerebrovascular disease显示文摘 | Matias-Guiu J Alvarez-Sabin J Codina A | 1997 | RevNeurol1997，25，147： | 1 |
| 13 | Reappraisal of the intracranial pressure and cerebrospinal fluid dynamics in patients with the so- called 'normal pressure hydrocephalus' syndrome显示文摘 | Sahuquillo J Rubio E Codina A | 1991 | Acta Neurochir (Wien)1991，112，： | 1 |
| 14 | A predictor-corrector scheme stabilized finite element for the incompressible Navier-Stokes equations using a nodal-based imple- mentation 显示文摘 | CODINA R FOLCH A | 2004 | International Journal for Numerical Methods in Fluids2004，44，5： | 1 |
| 15 | Gallstone Ileus: results of analysis of a series of 40 patients显示文摘 | Rodriguez Hermosa JI Codina Cazador A | 2001 | Gastroenterol Hepatol2001，24，10： | 1 |
| 16 | Reconstitution of somatostatin and muscarinie receptor mediated simulation of K^+ channels by isolated GK protein in elonal rat anterior pituitary cell membranes显示文摘 | Yantani A Codina J Sekura RD | 1987 | Mol Endoerinol1987，1，： | 1 |
| 17 | Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors显示文摘 | Codina A Love JD Li Y | 2005 | Proc Natl Acad Sci USA2005，102，8： | 1 |
| 18 | Detection of heavy metal toxicity and genotoxicity in wastewaters by microbial assay 显示文摘 | Codina J Perez-Garcia A De Vicente A | 1994 | Water Science & Technology1994，30，10： | 1 |
| 19 | Antipnospholipid antibodies in cere-bral ischmina显示文摘 | MONTALRAN J CODINA A ORDI | 1991 | Stroke1991，22，6： | 1 |
| 20 | Parkinsonism in neurobrucellosis显示文摘 | Molins A Montalbán J Codina A | | 0，，12： | 1 |
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