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| 1 | Antibacterial,pro-angiogenic and pro-osteointegrative zein-bioactive glass/copper based coatings for implantable stainless steel aimed at bone healing显示文摘Stainless steel implants are suitable candidates for bone replacement due to their cytocompatibility and mechanical resistance,but they suffer from lack of bioactivity and are prone to bacterial infections.Accordingly,to overcome those limitations,in this study we developed by electrophoretic deposition(EPD),an innovative surface coating made of(i)zein,a natural fibroblast-friendly polymer,(ii)bioactive glass,a pro-osteogenic inorganic material and(iii)copper containing bioactive glass,an antibacterial and pro-angiogenic material.FESEM images confirmed that porous,uniform and free of cracks coatings were obtained by EPD;moreover,coatings were resistant to mechanical stress as demonstrated by the tape test,resulting in a 4B classification of adhesion to the substrate.The coatings were cytocompatible as indicated by metabolism evaluation of human fibroblasts,endothelial cells and mature or progenitor osteoblasts cultivated in direct contact with the specimens.They also maintained pro-osteogenic properties towards undifferentiated progenitor cells that expressed osteogenic genes after 15 days of direct cultivation.Copper conferred antibacterial properties as biofilm formation of the joint pathogens Staphylococcus aureus,Staphylococcus epidermidis and Escherichia coli was significantly reduced in comparison with copper-free coatings(p<0.05).Moreover,this anti-infective activity resulted as targeted towards bacteria while the cells viability was preserved when cells and bacteria were cultivated in the same environment by a co-culture assay.Finally,copper ability to recruit blood vessels and to inhibit bacterial infection was confirmed in vivo where the growth of S.aureus biofilm was inhibited and the formation of new(<50μm diameter spread)blood vessels was observed. | Laura Ramos Rivera Andrea Cochis Sarah Biser Elena Canciani Sara Ferraris Lia Rimondini Aldo R.Boccaccini | 2021 | Bioactive Materials2021，6，5： | 2 |
| 2 | A large outbreak of mumps in the postvaccine era显示文摘 | Wharton M Cochi SL Hutcheson RH | 1988 | J Infect Dis1988，158，6： | 1 |
| 3 | Decline of childhood Hae- mophilus influenzae type b(Hib) disease in the Hib vaccineera显示文摘 | Adams WG Dearer KA Cochi SL | 1993 | JAMA1993，269，2： | 1 |
| 4 | Cost-effectiveness of a routine vari- celia vaccination program for US children显示文摘 | Lieu TA Cochi SL Black SB | 1994 | JAMA1994，271，5： | 1 |
| 5 | Parameters Estimation of a PEM Fuel Cell Polarization Curve and Analysis of Their Behavior with Temperature显示文摘 | Santarelli M G Torchio M F Cochis P | | 0，，02： | 1 |
| 6 | Decline of childhood Haemophilus influenzae type b(Hib) disease in the Hib vaccin- eera显示文摘 | Adams WG Deaver KA Cochi SL | 1993 | JAMA1993，269，2： | 1 |
| 7 | Outbreak of poliomye- litis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus 显示文摘 | Kew O Morris-Glasgow V Landaverde M Burns C Shaw J Garib Z Andr6 J Blackman E Freeman C J Jorba J Sutter R Tambini G Venczel L Pedreira C Laender F Shimizu H Yoneyama T Miyamura T van Der Avoort H Oberste M S Kilpatriek D Cochi S Pallansch M de Quadros C | 2002 | Science2002，296，5566： | 1 |
| 8 | Epidemiology of poliomyelitis in the United States one decade after the last reported cases of indigenous wild virus-associated disease显示文摘 | Sutter R W Cochi S L | 1992 | Clinical Infectious Disease1992，14，： | 1 |
| 9 | Framework for evaluating the risks of paralytic poliomyelitis after global interruption of wild poliovir-us transmission显示文摘 | AYLWARD RB COCHI SL | 2004 | Bull World Health Organ2004，82，1： | 1 |
| 10 | Differential diagnosis and outcome of fetal intracranial hypoechoic lesions:Report of 21 cases显示文摘 | Falco P Perelo A Sandri F Cochi G Ancora G | 1997 | Ultrasound Obstet Gynecol1997，9，： | 1 |
| 11 | Epidemiology of Poliomy- elitis in the United States one Decade After the Last Reported Case of Indigenous Wild Virus-associated Disease 显示文摘 | Strebel PM Sutter RW Cochi SL | 1992 | Clinical Infectious Diseases1992，14，2： | 1 |
| 12 | Tissue-engineered skin substitutes:an overview显示文摘 | Catalano E Cochis AiVaroni E | 2013 | Journal of Artificial Organs2013，16，4： | 1 |
| 13 | Decline of childhood Haemophilus influenzae type b (Hib) disease in the Hib vaccine era显示文摘 | Adams WG Deaver KA Cochi SL | 1993 | JAMA1993，269，2： | 1 |
| 14 | Overview of neonatal listeriosis显示文摘 | Albritton WL Cochi SL Feeley JC | 1984 | Clin Invest Med1984，7，： | 1 |
| 15 | A new epidemiologic and laboratory classification system for paralytic poliomyelitis cases 显示文摘 | Sutter RW Brink EW Cochi SL | 1989 | Am J Public Health1989，79，4： | 1 |
| 16 | Pasteurizedmilk as a vehicle of infection in an outbreak of listeriosis显示文摘 | Fleming DW Cochi SL MacDonald KL | 1985 | N Engl J Med1985，312，7： | 1 |
| 17 | Pasteurizedmilk as a vehicle of infection in an outbreak of listeriosis显示文摘 | FLEMING D W COCHI S L MACDONALD K L | 1985 | The NewEngland Journal of Medicine1985，312，： | 1 |
| 18 | Commentary: The unfolding story of global poliomyelitis eradication 显示文摘 | Cochi SL | 1997 | J Infect Dis1997，，： | 1 |
| 19 | Effect of air polishing with glycine powder on titanium abutment surfaces显示文摘 | Cochis A Fini M Carrassi A | 2013 | Clin Oral Implants Res2013，24，8： | 1 |
| 20 | Pricing in computer networks:motivation ,formulation ,and example显示文摘 | Cochi R Shenker S Estrin D | 1993 | IEEE/ACM Transactions on Networking1993，1，6： | 1 |
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