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| 1 | Liver injury in the era of COVID-19显示文摘Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has undoubtedly revolutionized the whole globe and given a new point of view on respiratory tract infections.Nevertheless,coronavirus disease 2019(COVID-19)cannot be perceived as a disease limited only to pneumonia with diverse severity.More and more reports have demonstrated a wide range of possible systemic symptoms,including hepatic complications.Liver injury has been observed in a significant proportion of patients,especially in those with a severe or critical illness.COVID-19 might provoke a deterioration of liver function in patients with already diagnosed chronic liver diseases and without pre-existing liver disorders.The deterioration of liver function worsens the prognosis,increases the risk of a severe course of SARS-CoV-2 infection and prolongs the hospital stay.In general,patients who develop liver dysfunction in COVID-19 are mainly males,elderly people,and those with higher body mass index.The underlying mechanisms for hepatic failure in patients infected with SARS-CoV-2 are still unclear,nevertheless liver damage appears to be directly connected with virus-induced cytopathic effects.A liver injury observed during hospitalization might be simultaneously caused by the use of potentially hepatotoxic drugs,mainly antiviral agents.This minireview focuses on a possible relationship between COVID-19 and the liver,potential molecular mechanisms of liver damage,the characteristics of liver injury and suggested factors predisposing to hepatic manifestations in COVID-19 patients. | Halina Cichoż-Lach Agata Michalak | 2021 | World Journal of Gastroenterology2021，27，5： | 6 |
| 2 | Red blood cell distribution width derivatives in alcohol-related liver cirrhosis and metabolic-associated fatty liver disease显示文摘BACKGROUND Looking for undiscovered blood markers of liver fibrosis and steatosis still remains an issue worth exploring.There are still plenty of unresolved issues related to the actual role of hematological indices as potential markers of liver function.AIM To study red blood cell distribution width(RDW),RDW-to-platelet ratio(RPR)and RDW-to-lymphocyte ratio(RLR) in alcohol-related liver cirrhosis(ALC) and metabolic-associated fatty liver disease(MAFLD).METHODS The study group was composed of 302 people:142 patients with ALC and 92 with MAFLD;68 persons were included as controls.RDW,RPR and RLR were measured in each person.Indirect and direct parameters of liver fibrosis were also assessed [aspartate transaminase to alkaline transaminase ratio,aspartate transaminase to platelet ratio index(APRI),fibrosis-4(FIB-4),gamma-glutamyl transpeptidase to platelet ratio(GPR),procollagen I carboxyterminal propeptide,procollagen Ⅲ aminoterminal propeptide,transforming growth factor-α,plateletderived growth factor AB,laminin].MELD score in ALC patients and nonalcoholic fatty liver disease(NAFLD) fibrosis score together with BARD score were obtained in the MAFLD group.The achieved results were compared to controls.Then a correlation between assessed markers was done.Diagnostic value of each investigated parameter and its suggested cut-off in the research group RESULTS RDW,RPR and RLR values turned out to be significantly higher in ALC and MAFLD groups compared to controls(ALC:P<0.0001;NAFLD:P<0.05,P<0.0001 and P<0.0001,respectively).RPR correlated positively with MELD score(P<0.01) and indirect indices of liver fibrosis(FIB-4 and GPR;P<0.0001) in ALC patients;negative correlations were found between PDGF-AB and both:RDW and RPR(P<0.01 and P<0.0001,respectively).RPR correlated positively with NAFLD fibrosis score and APRI(P<0.0001) in the MAFLD group;a positive relationship was observed between RDW and FIB-4,too(P<0.05).AUC values and suggested cut-offs for RDW,RPR and RLR in ALC patients were:0.912(>14.2%),0.965(>0.075) and 0.914(>8.684),respectively.AUC values and suggested cut-offs for RDW,RPR and RLR in MAFLD patients were:0.606(>12.8%),0.724(>0.047) and 0.691(>6.25),respectively.CONCLUSION RDW with its derivatives appear to be valuable diagnostic markers in patients with ALC.They can also be associated with a deterioration of liver function in this group. | Agata Michalak Małgorzata Guz Joanna Kozicka Marek Cybulski Witold Jeleniewicz Tomasz Lach Halina Cichoż-Lach | 2022 | World Journal of Gastroenterology2022，28，38： | 4 |
| 3 | Synthesis and characterization of monodisperse Eu^3+ doped gadolinium oxysulfide nanocrystals显示文摘Gd_2O_2S:Eu^(3+) nanoparticles were synthesized using two step process consisting of sulfuration of basic carbonates obtained by homogenous precipitation.Annealing of lanthanide nitrates at total concentration of 5×10^(-3) mol/L in a water solution containing relatively high,three molar concentration of urea ensured the optimal conditions for the reproducible preparation of uniform and small spherical particles.During sulfuration step elemental sulfur was mixed with precursor which eliminated necessity of using an auxiliary furnace and provided sulfur-reach reaction atmosphere.Such optimized protocol afforded synthesis of spherical and non-agglomerated nanoparticles with diameter smaller than 100 nm.The precursors morphology was maintained,but particles size was reduced by 15%-20%during sulfuration.The results indicated that higher emission intensity was observed for Gd_2O_2S:Eu^(3+)(8%)oxysulfide sample synthesized using crystalline Gd(CO_3)OH precursor,than for that obtained from amorphous Gd_2(OH)_2(CO_3)_2·H_2O precursor,although some further efforts to improve morphology of the former are still required. | J. Cichos M. Karbowiak D. Hreniak W. Strek | 2016 | Journal of Rare Earths2016，34，8： | 2 |
| 4 | Five-year Follow-up of a Randomized Clinical Trial of Total Thyroidectomy versus Dunhill Operation versus Bilateral Subtotal Thyroidectomy for Multinodular Nontoxic Goiter显示文摘 | Marcin Barczyński Aleksander Konturek Alicja Hubalewska-Dydejczyk Filip Go?kowski Stanis?aw Cichoń Wojciech Nowak | 2010 | World Journal of Surgery2010，，6： | 1 |
| 5 | Randomized clinical trial of visualization versus neuromonitoring of recurrent laryngeal nerves during thyroidectomy显示文摘 | Barczy(n)ski M Konturek A Cicho(n) S | 2009 | Br J Surg2009，96，3： | 1 |
| 6 | Minimally invasive video-assisted thyreoidectomy (MIVAT) with and without use of harmonic scalpel--a randomized study显示文摘 | Barczyński M Konturek A Cichoń S | 2008 | Langenbecks Arch Surg2008，393，5： | 1 |
| 7 | Influence of Self-trapped States on the Fluorescence Intermittency of Single Molecules显示文摘 | Schuster J Cichos F Borczyskowski Ch | | 0，，： | 1 |
| 8 | Non-variceal upper gastrointestinal bleeding guidelines on management 显示文摘 | Celinski K Cicho LH Madro A | 2008 | J Physiology Pharmacology2008，59，2： | 1 |
| 9 | Poststroke depression as a factor adversely affecting the level of oxidative damage to plasma proteins during a brain stroke显示文摘 | CICHO N BIJAK M MILLER E | 2015 | Oxidative Medicine and Cellular Longevity2015，2015，40： | 1 |
| 10 | Non- variceal upper gastrointestinal bleeding guidelines on management显示文摘 | CELINSKI K CICHO L H MADRO A | 2008 | J Physiol Pharmacol2008，59，2： | 1 |
| 11 | Minimally invasive video-assisted thyreoidectomy(MIVAT) with and without use of harmonic scalpel-a randomized study显示文摘 | Barczyński M Konturek A CichońS | 2008 | Langenbecks Arch Surg2008，393，5： | 1 |
| 12 | Minimally invasive video-assisted thyreoidectomy(MIVAT)with and without use of harmonic scalpela randomized study显示文摘 | Barczyński M Konturek A Cichoń S | 2008 | Langenbecks Arch Surg2008，393，5： | 1 |
| 13 | Randomized clinical trial of visualization versus neuromonitoring of recurrent laryngeal nerves during thyroidectomy显示文摘 | Barczy(n)ski M Konturek A Cicho(n) S | 2009 | Br J Surg2009，96，3： | 1 |
| 14 | Establishing the optimal pe-riod of storage for frozen Agaricus bisporus,depending on the pre-liminary processing applied显示文摘 | Jaworska G Bernas E CichońZ | | 0，，06： | 1 |
| 15 | Posterior Retroperitoneoscopic Adrenalectomy: A Comparison between the Initial Experience in the Invention Phase and Introductory Phase of the New Surgical Technique显示文摘 | Marcin Barczyński MD PhD Aleksander Konturek MD PhD Filip Go?kowski MD PhD Stanis?aw Cichoń MD PhD Bohdan Huszno MD PhD Klaus Peitgen MD Martin K. Walz MD PhD | 2007 | World Journal of Surgery2007，，1： | 1 |
| 16 | Randomized clinical trial of visualization versus neuromonitoring of recurrent laryngeal nerves during thyroidectomy显示文摘 | Barczyński M Konturek A Cichoń S | | 0，，： | 1 |
| 17 | Therapeutic antitumor potential of endoglin-based DNA vaccine combined with immunomodulatory agents显示文摘 | Jarosz M Jazowiecka-Rakus J CichońT | 2013 | Gene Ther2013，20，3： | 1 |
| 18 | Randomized clinical trial of visualization versus neuromonitoring of recurrent laryngeal nervesduring thyroidectomy显示文摘 | Barczyn' ski M Konturek A Cicho~i S | 2009 | Br J Surg2009，96，3： | 1 |
| 19 | Randomized clinical trial of visualization versus neuromonitoring of recurrent laryngeal nerves during thyroidectomy显示文摘 | Barczyński M Konturek A Cichoń S | 2009 | Br J Surg2009，96，3： | 1 |
| 20 | Minimally invasive video-assisted thyreoidectomy(MIVAT)with and without use of harmonic scalpel-a randomized study显示文摘 | Barczyski M Konturek A Cicho S | | 0，，05： | 1 |
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