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| 1 | Thrombosis: Novel nanomedical concepts of diagnosis and treatment显示文摘Intravascular thrombosis, a critical pathophysiological feature of many cardiovascular disorders, leads to the formation of life-threatening obstructive blood clots within the vessels. Rapid recanalization of occluded vessels is essential for the patients' outcome, but the currently available systemic fibrinolytic therapy is associated with low efficacy and tremendous side effects. Additionally, many patients are ineligible for systemic thrombolytic therapy, either due to delayed admission to the hospital after symptom onset, or because of recent surgery, or bleeding. In order to improve the treatment efficacy and to limit the risk of hemorrhagic complications, both precise imaging of the affected vascular regions, and the localized application of fibrinolytic agents, are required. Recent years have brought about considerable advances in nanomedical approaches to thrombosis. Although these thrombustargeting imaging agents and nanotherapies are not yet implemented in humans, substantial amount of successful in vivo applications have been reported, including animal models of stroke, acute arterial thrombosis, and pulmonary embolism. It is evident that the future progress in diagnosis and treatment of thrombosis will be closely bound with the development of novel nanotechnology-based strategies. This Editorial focuses on the recently reported approaches, which hold a great promise for personalized, disease-targeted treatment and reduced side effects in the patients suffering from this life-threatening condition. | Iwona Cicha | 2015 | World Journal of Cardiology2015，7，8： | 4 |
| 2 | Connective tissue growth factor:context-dependent functions and mechanisms of regulation显示文摘 | Cicha I Goppelt-Struebe M | 2009 | Biofactors2009，35，2： | 1 |
| 3 | Carotid plaque vulnerability : a positive feedback between hemodynamic and biochemical mechanisms 显示文摘 | Cicha I Worner A Urschel K | 2011 | Stroke2011，42，： | 1 |
| 4 | Decreased numbers of reg- ulatory T cells are associated with human atherosclerotic le- sion vulnerability and inversely correlate with infiltrated ma- ture dendritic cells显示文摘 | Dietel B Cicha I Voskens CJ | 2013 | Atherosclerosis2013，230，1： | 1 |
| 5 | Connective tissue growth factor is released from platelets under high shear stress and is differentially expressed in endothelium along atheresclerotic plaques 显示文摘 | Cicha I Yilmaz A Suzuki Y | 2006 | Clin Hemorheol Microcirc2006，35，12： | 1 |
| 6 | Early failure of xenogenous de-cellularised pulmonary valve conduits--a Word of caution 显示文摘 | Ruffer A Purbojo A Cicha I | 2010 | Eur J Cardiothorac Surg2010，38，1： | 1 |
| 7 | Accumulation of immune cells and high expression of chemokines/chemokine receptors in the upstream shoulder of atherosclerotic carotid plaques显示文摘 | Yilmaz A Lipfert B Cicha I | | 0，，： | 1 |
| 8 | Decrease in Circulating Myeloid Dendritic Cell Precursors in Coronary Artery Disease显示文摘 | Yilmaz A Weber J Cicha I | 2006 | J Am Coll Cardiol2006，48，1： | 1 |
| 9 | CD 40/CD 154 system and pro-inflammatory cytokines in young healthy male smo- kers without additional risk factors for atherosclerosis显示文摘 | Garlichs C D Cicha I Raaz D | 2009 | In- flamm Res2009，58，6： | 1 |
| 10 | Bioreactor and scaffold design for the mechanical stimulation of anterior cruciate ligament grafts显示文摘 | Hohlrieder M Teuschl AH Cicha K | 2013 | Biomed Mater Eng2013，23，3： | 1 |
| 11 | Impact of telmisartan on the inflammatory state in patients with coronary athcrosclerosis--influence on IP-10, TNF-c and MCP-I显示文摘 | Klinghammer L Urschel K Cicha I | 2013 | Cytokine2013，62，2： | 1 |
| 12 | Decrease in circulating myeloid den- dritic cell precursors in coronary artery disease 显示文摘 | Yilmaz A Weber J Cicha I | 2006 | J Am Coil Cardiol2006，48，1： | 1 |
| 13 | Decrease in circulating mye- loid dendritic cell precursors in coronary artery disease显示文摘 | Yilmaz A Weber J Cicha I | 2006 | J Am Coil Cardiol2006，48，1： | 1 |
| 14 | Accumulation of immune cells and high expression of chemokines/chemo- kine receptors in the upstream shoulder of atherosclerotic carotid plaques 显示文摘 | Yilmaz A Lipfcrt B Cicha I | 2007 | Exp Mol Pathol2007，82，3： | 1 |
| 15 | Dietary sodium loading increases arterial pres-sure in afferent renal-denervated rats 显示文摘 | Kopp UC Cicha MZ Smith LA | 2003 | Hypertension2003，42，5： | 1 |
| 16 | Emergence of dendritic cells in repture-prone regions of vulnerable carotid plaques显示文摘 | Yilmaz A Lochno M Traeg F Cicha I Reiss C Stumpf C | 2004 | Atherosclerosis2004，176，1： | 1 |
| 17 | Connective tissue growth factor: context- dependent functions and mechanisms of regulation 显示文摘 | CICHA I GOPPELT-STRUEBE M | 2009 | Bio- factors2009，35，2： | 1 |
| 18 | Decrease in circulating myeloid dendritic cell precursors in coro- nary artery disease显示文摘 | YILMAZ A WEBER J CICHA I | 2006 | J Am Coll Cardiol2006，48，： | 1 |
| 19 | Sheer six,stess preconditioning modulates endothelial susceptibility to circulaing TNF-alpha and monocytic cell recruitment in a simplifiel of arterial bifurcations显示文摘 | Cicha I Beronow K Ramirez EL | 2009 | Atherosclerosis2009，207，1： | 1 |
| 20 | Garlichs CD Decreased num- bers of regulatory T cells are associated with human atherosclerot- ic lesion vulnerability and inversely correlate with infiltrated ma- ture dendritic ceils 显示文摘 | Dietel B Cicha I Voskens CJ | 2013 | Atherosclerosis2013，230，1： | 1 |
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