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| 1 | 陕西省2005年病毒性脑炎监测结果分析显示文摘目的通过对陕西省安康、宝鸡、渭南3个地区病毒性脑炎的监测,了解病毒性脑炎流行病学特征及流行性乙型脑炎(乙脑)发病情况。方法采用ELISA法检测乙脑IgM;由监测医院报告病例,县级疾病预防控制中心进行个案调查。结果398例病例中,乙脑IgM阳性病例76例,占19.10%。在发病7 d内、7 d后采集的血标本、脑脊液标本阳性率分别为26.24%,18.18%和20.59%,其阳性率差异无统计学意义。发病7 d内与7 d后采集的血标本与脑脊液检测结果一致率分别为86.67%和80.00%。病毒性脑炎发病6~9月较高,与乙脑IgM阳性病例时间分布基本一致,11月病毒性脑炎病例出现一个小高峰;病毒性脑炎病例中15岁以下占73.62%,乙脑IgM阳性病例中0~5岁最高占36.84%,其他病毒性脑炎5~10岁组最高占40.68%;乙脑IgM阳性病例中散居儿童和农民占比例较高为71.05%,其他病毒性脑炎学生占比例较高为56.83%;未接种及接种史不详在乙脑IgM阳性病例中占76.31%;出院时转归,乙脑IgM阳性病例和其他病脑治愈比例分别为67.11%,83.23%,病死率分别为9.21%,3.11%。结论乙脑病例在发病7 d内和7 d后采血进行IgM检测对乙脑诊断均有意义。应提高乙脑疫苗接种率,在作好儿童乙脑防治的同时,加强对成人乙脑防控工作。 | 张少白 李艺星 杨俊峰 刘西珍 夏雪琴 尹遵栋 梁国栋 武继守 Chutima Suraratdecha | 2007 | 中国公共卫生2007，23，9： | 10 |
| 2 | 陕西省三地区2005—2006年度病毒性脑炎病例监测分析显示文摘目的监测陕西省安康、宝鸡、渭南3个地区病毒性脑炎,了解流行病学特征和发病情况。方法2005年6月至2007年5月对监测医院报告的所有病毒性脑炎病例开展个案调查,同时采集血和/或脑脊液标本,用ELISA检测流行性乙型脑炎(乙脑)IgM抗体;用EpiData和Excel软件进行分析。结果监测病毒性脑炎1097例,对其中1053例(96.0%)检测乙脑IgM,阳性311例(29.5%)。监测的两年度内病毒性脑炎、乙脑病例均在7、8月份出现高峰,病毒性脑炎发病趋势与乙脑IgM阳性病例趋势基本一致;宝鸡、渭南和安康地区14岁以下年龄组人群乙脑IgM阳性病例分别为33.7%、43.9%和88.3%,其他病毒性脑炎在3个地区均是5~14岁组所占比例较高(53.3%);乙脑IgM阳性病例中散居儿童、农民和学生占85.2%,其他病毒性脑炎病例学生所占比例较高(51.0%);病例出院时398例中,乙脑IgM阳性病例和其他病毒性脑炎治愈比例分别为67.1%、83.7%,病死率分别为9.2%、3.1%。578例出院90d后随访,乙脑IgM阳性病例和其他病毒性脑炎治愈比例分别为69.6%、90.2%,病死率分别为13.6%、3.6%,留后遗症比例分别为10.0%、4.5%。结论病毒性脑炎的高发季节和乙脑一致,临床报告的乙脑病例中乙脑IgM阴性病例占45.6%,提示对临床报告的乙脑/病毒性脑炎病例进行乙脑实验室检测是非常必要的;不同地区乙脑高发人群存在差异,在预防控制中应引起重视。 | 张少白 尹遵栋 Chutima Suraratdecha Susan L. Hills 刘西珍 李艺星 夏雪琴 梁国栋 梁晓峰 | 2008 | 中华流行病学杂志2008，29，9： | 6 |
| 3 | Comparative study on physicochemical changes of muscle proteins from some tropical fish during frozen storage显示文摘 | Soottawat Benjakul Wonnop Visessanguan Chutima Thongkaew Munehiko Tanaka | 2003 | Food Research International2003，，8： | 4 |
| 4 | 陕西省流行性乙型脑炎疫苗接种及知信行调查分析显示文摘目的分析陕西省流行性乙型脑炎(乙脑)预防控制和乙脑疫苗接种现状,为制定乙脑预防控制策略提供思路。方法采用整群抽样法对宝鸡市6个县的3 781名儿童及家长进行问卷调查。结果9~21月龄、3岁、7岁乙脑疫苗基础免疫2针接种率分别为:33.17%、93.50%、91.27%,完成2、3、4针合格接种率分别为31.67%、28.63%、2.70%。家长不知道要接种、不知道接种时间、提供接种次数少是未接种及未及时接种的主要原因。3 781位儿童家长中有56.01%的人听说过乙脑,但其对乙脑的危害、传播途径及如何预防等知识知晓率偏低,61.17%人听说过乙脑疫苗,但仅有11.24%的家长知道乙脑疫苗第1针接种月龄。结论目前乙脑疫苗基础免疫接种不及时,合格接种率低,儿童家长对乙脑预防控制知识知晓率偏低,今后应提高乙脑疫苗的合格接种率,加大宣传力度,提高民众的主动防病意识。 | 张少白 尹遵栋 王莉霞 刘西珍 夏雪琴 李艺星 包风云 寇光平 徐永红 Chutima Suraratdecha 梁晓峰 | 2007 | 中国计划免疫2007，13，4： | 4 |
| 5 | The effect of surfactant on the physical properties of coconut oil nanoemulsions显示文摘The aim of this study was to develop the water compatible form of coconut oil through nanoemulsification. The effect of different types and amounts of surfactants on the physical characteristics of nanoemulsions containing coconut oil was investigated. Coconut oil nanoemulsions containing varied amounts of surfactants including polyethylene glycol octyl phenyl ether(PGO), polyoxyethylene sorbitan monostearate(POS), polyethylene glycol hydrogenated castor oil(PHC), sodium lauryl sulfate(SLS) and poloxamer 407(PLX) were formulated and comparatively evaluated for their physical properties. The results showed that the coconut oil nanoemulsions using PGO, POS and PHC as surfactants exhibited low percent creaming index indicating excellent stability, while those containing SLS and PLX demonstrated the higher percent creaming index suggesting lesser physical stability. The droplet sizes of nanoemulsions consisting of 5%(w/w) PGO, POS and PHC were 22.843, 4.458 and 0.162 μm, respectively. Thus, coconut oil nanoemulsions with the smallest size could be obtained when PHC was applied. Furthermore, the droplet size of nanoemulsions decreased from 33 μm to less than 200 nm with an increase in the amount of PHC from 1% to 10%(w/w). Additionally, the properties of coconut oil based nanoemulsions containing PHC were not changed through temperature cycling test. From these results, it was suggested that the fabrication of stable coconut oil nanoemulsions with small particle size could be easily achieved by using 5%(w/w) PHC as a surfactant. The knowledge gained from the study might provide the basic guideline for the fabrication of stable nanoemulsions for food, cosmetic and pharmaceutical fields in the future. | Sirikarn Pengon Nawinda Chinatangkul Chutima Limmatvapirat Sontaya Limmatvapirat | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，5： | 3 |
| 6 | Determination of mono-, di-, and trilaurin in modified coconut oil using HPLC–ELSD显示文摘Modified coconut oil (MCO) enriched with monolaurin (ML) was prepared by the glycerolysis of coconut oil (1)Glycerolysis converts dilaurin (DL) and trilaurin (TL) into ML, the lauric acid monoglyceride. ML has been found to have antiviral, antibacterial and antifungal activities (2)According to the antimicrobial activity, the glyceride composition of MCO was determined. | Juthaporn Ponphaiboon Sirikarn Pengon Amornrat Chaidedgumjorn Sontaya Limmatvapirat Chutima Limmatvapirata | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，1： | 2 |
| 7 | Design and characterization of monolaurin loaded electrospun shellac nanofibers with antimicrobial activity显示文摘The aim of this study was to elucidate the optimized fabrication factors influencing the formation and properties of shellac(SHL) nanofibers loaded with an antimicrobial monolaurin(ML). The main and interaction effects of formulation and process parameters including SHL content(35%–40% w/w), ML content(1%–3% w/w), applied voltage(9–27 kV) and flow rate(0.4–1.2 ml/h) on the characteristic of nanofibers were investigated through a total of 19 experiments based on a full factorial design with three replicated center points. As a result, the SHL content was the major parameter affecting fiber diameter. Another response result revealed that the SHL content would be also the most significant negative impact on amount of beads. An increase in the concentration of SHL leaded to a reduction in the amount of beads. From the results of characterization study, it was proved that ML might be entrapped between the chains of SHL during the electrospinning process exhibiting an excellent encapsulation. According to the response surface area, small(?488 nm) and beadless(?0.48) fibers were obtained with the SHL and ML contents of 37.5% and 1.1% w/w respectively, at the applied voltage of 18 k V and the flow rate of 0.8 ml/h. In addition, the results of the kill-kinetic studies showed that SHL nanofibers loaded with ML exhibited an excellent antibacterial activity against Staphylococcus aureus, while Escherichia coli was less affected due to the hydrophilic structure of the its outer membrane. ML also exerted an antifun-gal activity by reducing the number of Candida albicans colonies. Based on their structural and antimicrobial properties, SHL nanofibers containing ML could be potentially used as a medicated dressing for wound treatment. | Nawindac Chinatangkul Chutima Limmatvapirat Jurairatb Nunthanid Manee Luangtana-Anan Pornsak Sriamornsak Sontaya Limmatvapirat | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，5： | 2 |
| 8 | Comparative study on physicochemical changes of muscle proteins from some tropical fish during frozen storage显示文摘 | Soottawat Benjakul Wonnop Visessanguan Chutima Thongkaew Munehiko Tanaka | 2003 | Food Research International2003，，8： | 2 |
| 9 | Experimental study on drying of chilli in a combined microwave-vacuum-rotary drum dryer显示文摘 | Kaensup W Chutima S Wongwises S | | 0，，10： | 1 |
| 10 | Comparative study on physicochemical changes of muscle proteins from some tropical fish during frozen storage 显示文摘 | Soottawat Benjakul Wonnop Visessanguan Chutima Thongkaew | 2003 | Food Research International2003，36，： | 1 |
| 11 | Enhanced enteric properties and stability of shellac films through composite salts formation显示文摘 | Sontaya L Chutima L Satit P | 2007 | European Journal of Pharmaceutics and Biopharmaceutics2007，67，3： | 1 |
| 12 | Comparative study on physicochemical changes of muscle proteins from tropi- cal fish during frozen storage显示文摘 | Soottawat B Wonnop V Chutima T | 2003 | Food Research International2003，36，8： | 1 |
| 13 | Formation of shellac succinate having improved enteric film properties through dry media reaction显示文摘 | Sontaya L Danuch P Chutima L | 2008 | European Journal of Pharmaceutics and Biopharmaceutics2008，70，13： | 1 |
| 14 | J Org Chem显示文摘 | Tirayut Vilaivan Chutima Winotapan Vorawit Banphavichit | 2005 | 70: 3464-34712005，70，： | 1 |
| 15 | Comparative study on physicochemical changes of muscle proteins from some tropical fish during frozen storage显示文摘 | Soottawat Benjakul Wonnop Visessanguan Chutima Thongkaew Munehiko Tanaka | 2003 | Food Research International2003，，8： | 1 |
| 16 | Experimental study on drying of chilli in a combined microwave-vacuum rotary drum dryer显示文摘 | Kaensup W Chutima S Wongwises S | 2002 | Drying Technology2002，20，10： | 1 |
| 17 | Formulation and evaluation of gels containing coconut? kernel extract for topical application显示文摘The biological activity of coconut( Cocos nucifera L.) extracts from its kernels and various parts was reported by many previous studies, it is therefore believable that the extracts of its kernels might show some activities in topical formulations. Among several kernel extracts, the TC06 extract prepared by soaking the steamed coconut kernels in hot water showed the highest total phenolic content(6.98 ± 0.30 mg GAE/g extract) and the strongest antioxidant activity as determined using FRAP and DPPH methods with a reducing power value of 4.12 ± 0.16 mg AAE/g of extract and an SC 50 value of 2.38 ± 0.14 mg/ml, respectively. In addition, this extract did not display any cytotoxic effects in the concentration range of 50–3200 μg/ml. Meanwhile, it revealed cytoprotective effects against t-BHP-induced cytotoxicity in HaCaT cells at concentrations higher than 400 μg/ml. The results of phytochemical investigations including a chemical color test, TLC, 1 H NMR and FTIR suggested that the TC06 extract was mainly composed of flavonoids and terpenoids. Furthermore, the concentrations of heavy metals including As, Cd, Hg, and Pb in the TC06 extract were below permissible limits. According to the solubility, the TC06 extract was incorporated into gels using Carbopol Ultrez 21 as a gelling agent. The formulated gel containing 3%(w/w) TC06 extract was stable at 4 °C and 25 °C with 75% RH throughout the storage period. It was found that the Carbopol Ultrez 21-based hydroalcoholic gel containing an aqueous extract of coconut kernels exhibited antioxidant activities in the two assays and showed a sufficient consistency, a pleasing color, and a non-oily perception during the period of observation. | Wantanwa Krongrawa Sontaya Limmatvapirat Nushjira Pongnimitprasert Paranee Meetam Chutima Limmatvapirat | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，5： | 1 |
| 18 | Experimental study on drying chilli in a combined microwavevacuum-rotary drum dryer显示文摘 | KANESUP W CHUTIMA S WONGWISES S | 2002 | Drying Technology2002，20，： | 1 |
| 19 | Experi-mental study on drying of chilli in a combined microwave-vacuum-rotary drum dryer显示文摘 | Kanesup W Chutima S Wongwises S | | 0，，10： | 1 |
| 20 | Nevirapine induces apoptosis in liver(HepG2) cells显示文摘Objective: To generate insights into the mechanism of NVP induced hepatotoxicity. Methods: Liver(HepG2) cells were cultured with various concentrations of NVP. This cell line was chosen because it has low expression of cytochrome P450, allowing evaluation of the effects of NVP rather than specific metabolites. Cytotoxicity was determined using a proliferation assay and cell numbers were monitored using trypan blue exclusion assay for long term culture experiments and apoptosis induction was determined by morphological and biochemical investigation. Results: HepG2 cells treated with the highest concentration of NVP tested(819 μM) initially showed a rounded morphology and all cells had died by week three of exposure. Nuclear condensation and fragmentation, increased Annexin V/propidium iodide staining and caspase 9 activation all supported the induction of apoptosis in HepG2 cells in response to NVP treatment. Conclusions: There is a clear induction of apoptosis in response to NVP which suggests that NVP has significant cytotoxicity, over and above any cytotoxicity of metabolites and may contribute directly to patient hepatotoxicity. | Jeerang Wongtrakul Atchara Paemanee Phitchayapak Wintachai Chutima Thepparit Sittiruk Roytrakul Thananya Thongtan Kanokwan Janphen Khuanchai Supparatpinyo Duncan R.Smith | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，6： | 1 |
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