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2篇 您的检索式：作者名="Chunjun Qin"

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		题名	作者	年代	出处	被引量
	1	Recent advances in synthetic carbohydrate-based human immunodeficiency virus vaccines显示文摘An effective vaccine for human immunodeficiency virus(HIV) is urgently needed to prevent HIV infection and progression to acquired immune deficiency syndrome(AIDS). As glycosylation of viral proteins becomes better understood, carbohydrate-based antiviral vaccines against special viruses have attracted much attention. Significant efforts in carbohydrate synthesis and immunogenicity research have resulted in the development of multiple carbohydrate-based HIV vaccines. This review summarizes recent advances in synthetic carbohydrate-based vaccines design strategies and the applications of these vaccines in the prevention of HIV.	Zhenyuan Wang Chunjun Qin Jing Hu Xiaoqiang Guo Jian Yin	2016	Virologica Sinica2016，31，2：	2
	2	Immunological Exploration of Helicobacter pylori Serotype O2 O-Antigen by Using a Synthetic Glycan Library显示文摘Helicobacter pylori(H.pylori)infection is a threat to human health.The lipopolysaccharide(LPS)O-antigen holds promise for developing vaccines.It is meaningful to explore the immunological activity of oligosaccharides with different lengths and frameshifts for antigen development.Herein,a glycan library of H.pylori O2 O-antigen containing eight fragments is constructed.After screening with anti-H.pylori O2 LPS sera and patients’sera by glycan microarray,the disaccharide HPO2G-2b and trisaccharide HPO2G-3a show strong antigenicity and then are separately conjugated with carrier protein CRM197.Both glycoconjugates elicit a robust immunoglobulin G(IgG)immune response in rabbits.The anti-HPO2G-3a IgG antibodies possess a much stronger binding affinity with the LPS and bacteria of H.pylori O2 than the anti-HPO2G-2b IgG antibodies.There is no cross-reaction between both sera IgG antibodies with LPS and bacteria of H.pylori O1,O6,and E.coli.The results demonstrate the trisaccharide HPO2G-3a is a promising candidate for H.pylori vaccine development.	Ming Zhao Guangzong Tian Chunjun Qin Xiaopeng Zou Peter H. Seeberger Jing Hu Jian Yin	2024	Chinese Journal of Chemistry2024，42，3：	0

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