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您的检索式：作者名="Chunfang Tong"
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| 1 | Cell adhesion mediated by β_2 integrin-ICAM-1 interactions显示文摘Introduction During the inflammatory responses,leukocytes are recruited at the site of high endothelial venule,roll over the endothelium surface,form the firm adhesion to spread out,and finally transmigrate across the blood vessel to the inflammatory site. | Changliang Fu,Dongying Zhan,Chunfang Tong,Manliu Wang,Shouqin Lü,Yan Zhang,Mian Long(1 Key Laboratory of Microgravity,Institute of Mechanics,Chinese Academy of Sciences,2 National Microgravity Laboratory and 3 Center of Biomechanics,and Bioengineering,Institute of Mechanics,Chinese Academy of Sciences,Beijing 100190,China.) | 2010 | 医用生物力学2010，25，S1： | 0 |
| 2 | Mechanical Strength and Structural Basis ofβ2 Integrin to Mediate Neutrophil Accumulation on Liver Sinusoidal Endothelial Cells:A Study Using Atomic Force Microscopy and Molecular Dynamics Simulations显示文摘Neutrophil(PMN)accumulation on liver sinusoidal endothelial cells(LSECs)is crucial to pathogen clearance and tissue damage in the liver sinusoids and controlled by a series of adhesion molecules expressed on the surface of PMNs and LSECs.The role of lymphocyte function-associated antigen-1(LFA-1)and macrophage-1 antigen(Mac-1)in this process is still contentious.Here we compared the dynamic force spectra of the binding ofβ2 integrin to intercellular adhesion molecule-1(ICAM-1)on LSECs using atomic force microscopy(AFM)and performed free and steered molecular dynamics(MD)simulations to analyze their structural bases of LFA-1-or Mac-1-I-domain and ICAM-1-D1 or D3 pair in their force spectra.Our AFM data suggest that the mechanical strength of LFA-1-ICAM-1 bond is significantly stronger than that of Mac-1-ICAM-1 bond,implying a dominate role for LFA-1 to mediate PMN adhesion under shear flow.MD simulations indicated that spontaneous dissociation of Mac-1-I-domain vs.ICAMD3-domain is slower with the stronger interaction energy than that for LFA-1 I-domain vs.ICAM-D1-domain and that the rupture force for Mac-1 is lower than that for LFA-1,which are in qualitative agreement with the above experimental observations.These data indicate that the biomechanical features of LFA-1 and Mac-1 to mediate PMN adhesion on LSECs in vitro are similar with those in other tissues like cerebrovascular endothelium,while Mac-1-mediated PMN recruitment in liver sinusoids may stem from the slow blood flow in vivo.These findings further the understandings of PMN recruitment under shear flow in liver sinusoids. | Ning Li Xiao Zhang Peiwen Li Hao Yang Chunfang Tong Shouqin Lü Yan Zhang Zhiyi Ye Jun Pan Mian Long | 2018 | Computer Modeling in Engineering & Sciences2018，，8： | 0 |
| 3 | Prospect of Sinopec's Exploration for Natural Gas显示文摘Current state of Sinopec’s exploration for natural gasDistribution of exploration area and resource baseSinopec now owns the exploration right of 364 blocks, with the acreage about one million square kilometers. The company mainly carries out exploration for oil and | Long Shengxiang Zhu Hong Zhu Tong Chen Chunfang Xiao Kaihua | 2008 | China Oil & Gas2008，15，3： | 0 |
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