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5篇 您的检索式:作者名="Chrysanthy I"
    题名 作者 年代 出处 被引量
1Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain 显示文摘Chrysanthy I Friederike B Michael M 1999Science1999,283,5398:1
2Blockade of NMDA receptors and apoptic neurodegeneration in the developing brain显示文摘Chrysanthy I Friederike B Michael M 1999Science1999,283,:1
3Early ileocolonoscopy with biopsy for the evaluation of persistent post-transplantation diarrhea显示文摘AIM: To investigate the signifi cance of ileocolonoscopy with histology in the evaluation of post-transplantation persistent diarrhea (PD). METHODS: We retrospectively reviewed all records of renal transplant patients with PD, over a 3-year period. All patients were referred for ileocolonoscopy with biopsy, following a negative initial diagnostic work up. Clinical and epidemiological data were compared between cases with infectious or drug-induced diarrhea. RESULTS: We identif ied 30 episodes of PD in 23 renaltransplant patients (1-3 cases per patient). There were 16 male patients and the mean age at the time of PD was 51.4 years. The average time from transplantation to a PD episode was 62.3 ± 53.2 mo (range 1-199 mo). Ileocolonoscopy detected mucosal abnormalities in 19 cases, whereas the intestinal mucosa appeared normal in 11 cases. Histological examination achieved a specific diagnosis in 19/30 cases (63.3%). In nine out of 11 cases (82%) with normal endoscopic appearance of the mucosa, histological examination of blinded biopsies provided a specif ic diagnosis. The etiology of PD was infectious in 11 cases (36.6%), drug-related in 10 (33.3%), of other causes in three (10%), and of unknown origin in six cases (20%). Infectious diarrhea occurred in significantly longer intervals from transplantation compared to drug-related PD (85.5 ± 47.6 mo vs 40.5 ± 44.8 mo, P < 0.05). Accordingly, PD due to drug-toxicity was rarely seen after the f irst year post-transplantation. Clinical improvement followed therapeutic intervention in 90% of cases. Modif ication of immunosuppressive regimen was avoided in 57% of patients. CONCLUSION: Early ileocolonoscopy with biopsies from both affected and normal mucosa is an important adjunctive tool for the etiological diagnosis of PD in renal transplant patients.Giorgos Bamias John Boletis Theodoros Argyropoulos Chrysanthi Skalioti Spyros I Siakavellas Ioanna Delladetsima Irene Zouboulis-Vafiadis George L Daikos Spiros D Ladas 2010World Journal of Gastroenterology2010,16,30:1
4Blockade of NMDA receptors and apoptic neurode generation in the developing brain显示文摘Chrysanthy I Friederike B Michael M 1999Science1999,,283:1
5Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain显示文摘Chrysanthy I Friederike B MichaelM 1999Science1999,283,:1
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