|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Multiplex RT-PCR-based detections of CEA, CK20 and EGFR in colorectal cancer patients显示文摘AIM: To develop a multiplex reverse transcription polymerase chain reaction (RT-PCR) method detecting cir-culating tumor cells in the peripheral blood of colorectal cancer (CRC) patients. METHODS: Peripheral blood samples were collected from 88 CRC patients and 40 healthy individuals from the blood donors' clinic and subsequently analyzed by multiplex RT-RCR for the expression of carcinoembryonic antigen (CEA), cytokeratin 20 (CK20) and epidermal growth factor receptor (EGFR) mRNA. The analysis involved determining the detection rates of CEA, CK20 and EGFR transcripts vs disease stage and overall survival. Median follow-up period was 19 mo (range 8-28 mo). RESULTS: Rates of CEA, CK20 and EGFR detection in CRC patients were 95.5%, 78.4% and 19.3%, respectively. CEA transcripts were detected in 3 healthy volunteer samples (7.5%), whereas all control samples were tested negative for CK20 and EGFR transcripts. The increasing number of positive detections for CEA, CK20 and EGFR transcripts in each blood sample was positively correlated with Astler-Coller disease stage (P< 0.001) and preoperative serum levels of CEA (P=0.029) in CRC patients. Data analysis using Kaplan-Meier estimator documented signif icant differences in the overall survival of the different CRC patient groups as formed according to the increasing number of positivity for CEA, CK20 and EGFR transcripts. CONCLUSION: These data suggest that multiplex RTPCR assay can provide useful information concerning disease stage and overall survival of CRC patients. | Aikaterini Tsouma Chrysanthi Aggeli Panagiotis Lembessis George N Zografos Dimitris P Korkolis Dimitrios Pectasides Maria Skondra Nikolaos Pissimissis Anastasia Tzonou Michael Koutsilieris | 2010 | World Journal of Gastroenterology2010，16，47： | 19 |
| 2 | Solitary fibrous tumor of the liver expressing CD34 and vimentin:A case report显示文摘A case of a successfully treated solitary fibrous tumor (SFT) of the liver is reported.An 82-year-old female presented with left upper abdominal discomfort,a firm mass on palpation,and imaging studies revealed a large tumor,15 cm in diameter,arising from the left lobe of the liver.A formal left hepatectomy was performed.Microscopic evaluation showed spindle and fibroblast-like cells within the collagenous stroma.Immunohistochemistry disclosed diffuse CD34 and positive vimentin,supporting the diagnosis of a benign SFT.The patient remained well 21 months after surgery.SFT of the liver is a very rare neoplasm of mesenchymal origin.In most cases it is a benign lesion,although some may have malignant histological features and recur locally or metastasize.With less than 30 reported cases in the literature,little can be said regarding its natural history or the benefits of adjuvant radiochemotherapy.Complete surgical resection remains the cornerstone of its treatment. | Dimitris P Korkolis Katerina Apostolaki Chrysanthi Aggeli George Plataniotis Emmanuel Gontikakis Dimitra Volanaki Maria Sebastiadou Dimitris Dimitroulopoulos Dimitris Xinopoulos George N Zografos Perikles P Vassilopoulos | 2008 | World Journal of Gastroenterology2008，14，40： | 3 |
| 3 | Excellent long term patient and renal allograft survival after ABO-incompatible kidney transplantation:Experience of one center显示文摘AIM: To investigate the long-term results of ABOincompatible(ABOi) kidney transplantation in a single center in Greece.METHODS: Thirty consecutive ABOi kidney transplantations were performed from June 2005 to December 2013. All patients received rituximab one month prior to transplantation. Immunoadsorption therapy was performed for the removal of anti-A/B Ig G antibodies until the titer was ≤ 1:16. Additional apheresis sessions were performed post-operatively. Intravenous immunoglobulin and oral immunosuppression consisting of tacrolimus(TAC) in combination with either everolimus or mycophenolate acid was administered. We compared the long term results of our ABOi group to those of a matched group of 30 ABO compatible(ABOc) living kidney recipients with similar baseline characteristics. The ABOc recipients received an immunosuppressive regimen consisting of TAC and mycophenolate acid. All patients in both groups received induction therapy with Basiliximab or Daclizumab, whereas corticosteroids were instituted on the day of surgery. During the followup period, indication biopsies were performed and interpreted by an experienced nephropathologist. The parameters we analyzed included the following: Donor/recipient age, gender, blood type, human leukocyte antigen mismatches, panel reactive antibodies, primary cause of renal failure, mean time on dialysis, immunosuppressive regimen, patient survival, graft outcome, incidence of rejections, surgical and infectious complications.RESULTS: The mean follow-up period was 6 years(range 1 to 9 years). A mean of 5.0 ± 3.0(range 0-14) pre-transplant immunoadsorptions were required in order to reach the target titer. Patient survival in ABOi group in comparison to ABOc group at 1, 3, 5 and 8 years did not differ significantly(100% vs 100%, 96% vs 100%, 92% vs 100% and 92% vs 100%, P = ns). Additionally, graft survival was similar in the two groups at the same time points(100% vs 100%, 96% vs 96%, 92% vs 96% and 81% vs 92%, P = ns). The mean serum creatinine and the estimated glomerular filtration rate by the modification of diet in renal disease formula at 1, 3, 5 and 8 years did not differ significantly between ABOi and ABOc group. None of the patients in the ABOi group developed acute or chronic antibodymediated rejection evidenced by histological signs. Four patients(13.3%) in the ABOi group and 3(10%) in the ABOc group experienced acute cellular rejection, which was treated successfully in all cases. Bacterial and viral infections were also similar between the two groups.CONCLUSION: ABOi kidney transplantation is a safe and effective alternative that enables kidney transplantation in countries with unacceptably long deceaseddonor waiting lists. | Christina Melexopoulou Smaragdi Marinaki George Liapis Chrysanthi Skalioti Maria Gavalaki George Zavos John N Boletis | 2015 | World Journal of Transplantation2015，5，4： | 2 |
| 4 | Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review显示文摘 | Evangelos Cholongitas Chrysanthi Mamou Kryssia I. Rodríguez‐Castro Patrizia Burra | 2014 | Transpl Int2014，，10： | 2 |
| 5 | Supporting mobile database access through query by icons显示文摘 | A Massari S Weissman P K Chrysanthis | 1996 | International Journal of Distributed and Parallel Databases1996，4，3： | 1 |
| 6 | Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination显示文摘 | Levin ED Chrysanthis E Yacisin K | 2003 | Neurotoxicol Teratol2003，25，1： | 1 |
| 7 | Multiversion data broadcast显示文摘 | PITOURA E CHRYSANTHIS P K | 2002 | IEEE Transactions Computers2002，51，10： | 1 |
| 8 | On Indoor Position Location with Wireless LANs显示文摘 | Prasithsangaree P Krishnamurthy P Chrysanthis P K | 2002 | Telecommunications Program2002，，： | 1 |
| 9 | Synthesis of extended transaction models using ACTA显示文摘 | CHRYSANTHIS P K RAMAMRITHAM K | 1994 | Database Systems1994，19，3： | 1 |
| 10 | Multiversion data broadcast显示文摘 | Pitoum E Chrysanthis P K | 2002 | IEEE Transactions on Computers2002，51，10： | 1 |
| 11 | Multiversion data broadcast显示文摘 | Pitoura E Chrysanthis P K | 2002 | IEEE Transactions on Computers2002，51，10： | 1 |
| 12 | On-demand data broadcasting for mobile decision making显示文摘 | SHARAF M A CHRYSANTHIS P K | 2004 | Mobile networks and ap- plications2004，9，6： | 1 |
| 13 | Synthesis of extended transaction models using ACTA 显示文摘 | P K Chrysanthis K Ramamritham | 1994 | ACM Transactions on Database Systems (S0362-5915)1994，19，3： | 1 |
| 14 | Muhiversion data broadcast显示文摘 | Pitoura E Chrysanthis P K | 2002 | IEEE Trans Computers2002，51，10： | 1 |
| 15 | Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain 显示文摘 | Chrysanthy I Friederike B Michael M | 1999 | Science1999，283，5398： | 1 |
| 16 | Synthesis of extended transaction models using ACTA显示文摘 | Chrysanthis P K Ramamritham K | 1994 | Database Systems1994，19，3： | 1 |
| 17 | Supporting Mobile Database Access through Query by Icons显示文摘 | A Massari S Weissman and P K Chrysanthis | 1996 | Distributed and Parallel Database Journal (Special issue on databases and mobility)1996，，4： | 1 |
| 18 | Small-Diameter Artificial Arteries Engineered In Vitro显示文摘 | Brett C. Isenberg Chrysanthi Williams Robert T. Tranquillo | 2006 | Circulation Research2006，，1： | 1 |
| 19 | Successful en bloc resection of primary hepatocellular carcinoma directly invading the stomach and pancreas显示文摘Multivisceral surgical resection for cure was successfully performed in a 70-year-old man suffering from a primary hepatocellular carcinoma(HCC)associated with direct invasion to the stomach and pancreas.The patient presented with gastric outlet obstruction,upper abdominal pain and a history of chronic liver disease due to hepatitis B virus(HBV)infection.Upper gastro-intestinal(GI)endoscopy revealed an infiltrating tumor protruding through the gastric wall and obliterating the lumen.Computer tomograghy(CT)and magnetic resonance imaging(MRI)scan demonstrated a 15-cm tumor in the left lateral segment of the liver with invasion to the stomach and pancreas.Alpha-foetoprotein (AFP)levels and liver function tests were normal.The patient underwent an en bloc left hepatectomy,total gastrectomy,distal pancreatectomy with splenectomy and radical lymphadenectomy.Pathology revealed a poorly differentiated,giant cell HCC involving the stom-ach and pancreas.Disease-free margins of resection were achieved.The patient's postoperative course was uneventful.Sixteen months after surgery,he has norecurrence or distal metastasis.Direct invasion of HCC into the GI tract is rarely encountered.Complete surgical resection should be considered in selected patients with an appropriate hepatic functional reserve. | Dimitris P Korkolis Chrysanthi Aggeli George D Plataniotis Emmanuel Gontikakis Helen Zerbinis Nikitas Papantoniou Dimitris Xinopoulos Nikiforos Apostolikas Perikles P Vassilopoulos | 2009 | World Journal of Gastroenterology2009，15，9： | 1 |
| 20 | Blockade of NMDA receptors and apoptic neurodegeneration in the developing brain显示文摘 | Chrysanthy I Friederike B Michael M | 1999 | Science1999，283，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员