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| 1 | Epigallocatechin-3-gallate (EGCG) attenuates nflammation in MRL/Ipr mouse mesangial cells显示文摘 | Abigail Peairs Rujuan Dai Lu Gan Samuel Shimp M Nichole Rylander Liwu Li Christopher M Reilly | 2010 | Cellular & Molecular Immunology2010，7，2： | 12 |
| 2 | MicroRNA-let-7a promotes E2F-mediated cell proliferation and NFKB activation in vitro显示文摘Epigenetic 因素,包括的改变的 microRNA (miRNA ) 表示,可以在全身的豺狼座 erythematosus (SLE ) 贡献异常有免疫力的房间功能。MiRNA-let-7a (let-7a ) 被显示了直接改变房间周期前进和 proinflammatory cytokine 生产。由于在房间分割和发炎的 let-7a 的关键角色,我们调查了 let-7a-mediated 增长和 NFκ在 J774A.1 巨噬细胞和 MES 的 B translocation 在 vitro 的 13 个 mesangial 房间。在有 let-7a 的刺激免疫者的房间 transfected,房间增长显著地随着时间的过去被增加。在 S 和 G 2 阶段的刺激免疫者的房间的数字有重要增加。刺激免疫者的房间 overexpressing let-7a 增加了 NFκ 的原子 translocation; B。Bioinformatical 分析表明 E2F 家庭, G 1-S 转变的批评管理者,在他们的 mRNA 抄本为 let-7a 有潜在的有约束力的地点。Let-7a overexpression 显著地增加了房间周期使活跃之物 E2F2 的表示并且在刺激免疫者的房间增加了 retinoblastoma 蛋白质(Rb ) phosphorylation。房间周期禁止者 E2F5 显著地在刺激免疫者的 let-7a-transfected 房间被减少。Bioinformatical 分析揭示了 E2F2 和 NFκ B 是预言调整 let-7a 倡导者的抄写因素。我们与 E2F2 和 NFκ 用染色质 immunoprecipitation 由即时 RT-PCR 分析了 let-7a 的 transcriptional 规定; B 抗体。E2F2 和 NFκ 有增加;在在刺激免疫者的房间为 let-7a 倡导者充实的 DNA 的 B 绑定。Silencing E2F2 或 NFκ B 显著地减少了在刺激免疫者的房间的 let-7a 表示和 IL-6 生产。一起拿,我们的结果建议 let-7a 的 overexpression 可以在 SLE 贡献增生和 proinflammatory 反应。 | Cristen B Chafin Nicole L Regna David L Caudell Christopher M Reilly | 2014 | Cellular & Molecular Immunology2014，11，1： | 3 |
| 3 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 4 | Endovascular Stenting for Vertebral Artery Stenosis显示文摘 | J. Stephen Jenkins Samir N. Patel Christopher J. White Tyrone J. Collins John P. Reilly Paul W. McMullan Mark A. Grise Arthur G. Grant Stephen R. Ramee | 2010 | Journal of the American College of Cardiology2010，，6： | 1 |
| 5 | Vascularisation Pattern of Chronic Pancreatitis Compared with Pancreatic Carcinoma: Results from Contrast-Enhanced Endoscopic Ultrasound显示文摘 | Michael Hocke Christoph F. Dietrich Derek O'Reilly | 2012 | International Journal of Inflammation2012，，： | 1 |
| 6 | Using interactive management to facilitate a student-centred conceptualisation of critical thinking: a case study显示文摘 | Christopher P. Dwyer Michael J. Hogan Owen M. Harney John O’Reilly | 2014 | Educational Technology Research and Development2014，，6： | 1 |
| 7 | The effect of hepatic steatosis on survival following resection of colorectal liver metastases in patients without preoperative chemotherapy显示文摘 | Ed Parkin Derek A. O’Reilly Rene Adam Gernot M. Kaiser Christophe Laurent Dominique Elias Lorenzo Capussotti Andrew G. Renehan | 2012 | HPB2012，，6： | 1 |
| 8 | Vascularisation Pattern of Chronic Pancreatitis Compared with Pancreatic Carcinoma: Results from Contrast-Enhanced Endoscopic Ultrasound显示文摘 | Michael Hocke Christoph F. Dietrich Derek O’Reilly | 2012 | International Journal of Inflammation2012，，： | 1 |
| 9 | Acute kidney injury following spinal instrumentation surgery in children显示文摘AIM To determine acute kidney in jury(AKI) incidence and potential risk factors of AKI in children undergoing spinal instrumentation surgery.METHODS AKI incidence in children undergoing spinal instrumentation surgery at British Columbia Children's Hospital between January 2006 and December 2008 was determined by the Acute Kidney Injury Networ classification using serum creatinine and urine output criteria. During this specific time period, all patients following spinal surgery were monitored in the pediatric intensive care unit and had an indwelling Foley catheter permitting hourly urine output recording. Cases of AKI were identified from our database. From the remaining cohort, we selected group-matched controls that did not satisfy criteria for AKI. The controls were matched for sex, age and underlying diagnosis(idiopathic vs nonidiopathic scoliosis).RESULTS Thirty five of 208 patients met criteria for AKI with an incidence of 17%(95%CI: 12%-23%). Of all children who developed AKI, 17(49%) developed mild AKI(AKI Stage 1), 17(49%) developed moderate AKI(Stage 2) and 1 patient(3%) met criteria for severe AKI(Stage 3). An inverse relationship was observed with AKI incidence and the amount of fluids received intra-operatively. An inverse relationship was observed with AKI incidence and the amount of fluids received intra-operatively classified by fluid tertiles: 70% incidence in those that received the least amount of fluids vs 29% that received the most fluids(> 7.9, P = 0.02). Patients who developed AKI were more frequently exposed to nephrotoxins(non steroidal anti inflammatory drugs or aminoglycosides) than control patients during their peri-operative course(60% vs 22%, P < 0.001).CONCLUSION We observed a high incidence of AKI following spinal instrumentation surgery in children that is potentially related to the frequent use of nephrotoxins and the amount of fluid administered peri-operatively. | Jasper J Jobsis Abdullah Alabbas Ruth Milner Christopher Reilly Kishore Mulpuri Cherry Mammen | 2017 | World Journal of Nephrology2017，6，2： | 0 |
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