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| 1 | Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis显示文摘AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis(AIS) in order to evaluate their efficacy and level of evidence. METHODS: Selection criteria:(1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies;(2) participants: adolescents with AIS aged from 10 to 20 years; and(3) treatment: observation, bracing, and other. Search method: Ovid MEDLINE, Embase, the Cochrane Library, Pub Medand patent data bases. All years through August 2014 were included. Data were collected that showed an association between the studied characteristics and the progression of AIS or the severity of the spine deformity. Odds ratio(OR), sensitivity, specificity, positive and negative predictive values were also collected. A metaanalysis was performed to evaluate the pooled OR and predictive values, if more than 1 study presented a result. The GRADE approach was applied to evaluate the level of evidence.RESULTS: The review included 25 studies. All studies showed statistically significant or borderline association between severity or progression of AIS with the following characteristics:(1) An increase of the Cobb angle or axial rotation during brace treatment;(2) decrease of the rib-vertebral angle at the apical level of the convex side during brace treatment;(3) initial Cobb angle severity(> 25o);(4) osteopenia;(5) patient age < 13 years at diagnosis;(6) premenarche status;(7) skeletal immaturity;(8) thoracic deformity;(9) brain stem vestibular dysfunction; and(10) multiple indices combining radiographic, demographic, and physiologic characteristics. Single nucleotide polymorphisms of the following genes:(1) calmodulin 1;(2) estrogen receptor 1;(3) tryptophan hydroxylase 1;(3) insulin-like growth factor 1;(5) neurotrophin 3;(6) interleukin-17 receptor C;(7) melatonin receptor 1B, and(8) Scoli Score test. Other predictors included:(1) impairment of melatonin signaling in osteoblasts and peripheral blood mononuclear cells(PBMC);(2) G-protein signaling dysfunction in PBMC; and(3) the level of platelet calmodulin. However, predictive values of all these findings were limited, and the levels of evidence were low. The pooled result of brace treatment outcomes demonstrated that around 27% of patents with AIS experienced exacerbation of the spine deformity during or after brace treatment, and 15% required surgical correction. However, the level of evidence is also low due to the limitations of the included studies.CONCLUSION: This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria. | Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher MJ Cain Vikas V Patel Andrew P Bradford | 2015 | World Journal of Orthopedics2015，6，7： | 4 |
| 2 | G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow显示文摘 | Semerad CL Christopher MJ Liu F | 2005 | Blood2005，106，9： | 1 |
| 3 | Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice 显示文摘 | Christopher MJ Rao M Liu F | 2011 | J Exp Med2011，208，2： | 1 |
| 4 | Suppression of CXCL-12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization显示文摘 | Christopher MJ Liu F Hilton MJ | 2009 | Blood2009，114，7： | 1 |
| 5 | Molecular contribution to selection of intergeneric hybrids between sugarcane and the wild species Erianthus arundinaceus显示文摘 | George P Christopher MJ Carroll N J Berding N D'Hont A | 2000 | Genome2000，43，6： | 1 |
| 6 | The utility of procalcitonin in critically ill trauma patients显示文摘 | Sakran Joseph V Michetti Christopher P Sheridan MJ | 2012 | J Trauma Acute Care Surg2012，73，2： | 1 |
| 7 | Expression of the G-CSF receptor in monocytic ceils is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice 显示文摘 | Christopher MJ Rao M Liu F | 2011 | J Exp Med2011，208，2： | 1 |
| 8 | G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow显示文摘 | Semerad CL Christopher MJ Liu F | 2005 | Blood2005，106，9： | 1 |
| 9 | G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow 显示文摘 | Semerad CL Christopher MJ Liu F | 2005 | Blood2005，106，9： | 1 |
| 10 | Regulation of neutrophil homeostasis显示文摘 | Christopher MJ Link DC | 2007 | Current Opinion in Hematology2007，14，1： | 1 |
| 11 | Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice显示文摘 | Christopher MJ Rao M Liu F | 2011 | J Exp Med2011，208，2： | 1 |
| 12 | Regulation of neutrophil homeostasis显示文摘 | Christopher MJ Link DC | 2007 | Curr Opin Hematol2007，14，1： | 1 |
| 13 | G-CSF potently inhibits osteoblast activity and CXCL12 mRNA exp ression in the marrow bone显示文摘 | ]SEMERDA CL CHRISTOPHER MJ LIU F | 2005 | Blood2005，106，9： | 1 |
| 14 | G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the marrow bone显示文摘 | Christopher MJ Liu F | 2005 | Blood2005，106，9： | 1 |
| 15 | G-CSF potently inhabits osteblast activity and CXCL12 mRNA expression in the bone marrow显示文摘 | Semerad CL Christopher MJ Liu F | 2005 | Blood2005，106，9： | 1 |
| 16 | Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice显示文摘 | Christopher MJ Rao M Liu F | 2011 | J Exp Med2011，208，2： | 1 |
| 17 | Auditory motor inte- gration in oral and manual effectors 显示文摘 | Torrey MJ Edward O Christopher M | 2010 | J Mot Behav2010，42，4： | 1 |
| 18 | Regulation of neutrophil homeostasis显示文摘 | Christopher MJ Link DC | 2007 | Curr Opin Hematol2007，14，1： | 1 |
| 19 | Vocal cord dysfunction, paradoxie vocal fold motion, or laryngomalaeia? Our understanding requires an interdisciplinary approach显示文摘 | Christopher KL Morris MJ | 2010 | Otolaryngol Clin North Am2010，43，： | 1 |
| 20 | Land surface tempera-ture derived from the SSM/I passive microwave brightness tem- perature 显示文摘 | McFarland MJ Miller RL Christopher M | 1990 | IEEE Trans Geosci Remote Sensing1990，28，5： | 1 |
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