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您的检索式：作者名="Christopher B.Shields"
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| 1 | Technical comments on rodent spinal cord injuries models显示文摘Spinal cord injuries(SCI)in rodents have been created by laceration,contusion,compression,or intramedullary injection of toxic agents.The choice of an appropriate SCI model should be made for each study based on the experimental design,with care taken to avoid unintended complications such as hemorrhage.Technical comments will be made in this communication describing the 1)importance of vertebral stabilization,2)injury preparation,and 3)landmarks to improve the precision and reproducibility of the SCI. | Zoe Zhang Yi Ping Zhang Lisa B.E.Shields Christopher B.Shields | 2014 | Neural Regeneration Research2014，9，5： | 2 |
| 2 | Dynamic glial response and crosstalk in demyelination-remyelination and neurodegeneration processes显示文摘Multiple sclerosis is an autoimmune disease in which the immune system attacks the myelin sheath in the central nervous system.It is characterized by blood-brain barrier dysfunction throughout the course of multiple sclerosis, followed by the entry of immune cells and activation of local microglia and astrocytes.Glial cells(microglia, astrocytes, and oligodendrocyte lineage cells) are known as the important mediators of neuroinflammation, all of which play major roles in the pathogenesis of multiple sclerosis.Network communications between glial cells affect the activities of oligodendrocyte lineage cells and influence the demyelination-remyelination process.A finely balanced glial response may create a favorable lesion environment for efficient remyelination and neuroregeneration.This review focuses on glial response and neurodegeneration based on the findings from multiple sclerosis and major rodent demyelination models.In particular, glial interaction and molecular crosstalk are discussed to provide insights into the potential cell-and molecule-specific therapeutic targets to improve remyelination and neuroregeneration. | Tianci Chu Lisa B.E.Shields Wenxin Zeng Yi Ping Zhang Yuanyi Wang Gregory N.Barnes Christopher B.Shields Jun Cai | 2021 | Neural Regeneration Research2021，16，7： | 2 |
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