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1篇 您的检索式：作者名="Christiane Leovsky"

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		题名	作者	年代	出处	被引量
	1	Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model显示文摘Background:We investigated early hallmarks of putative therapeutic effects following systemic transplantation of bone marrow derived macrophages(BM-M)in APP/PS1 transgenic mice.Method:BM-M were transplanted into the tail vein and the animals analysed 1 month later.Results:BM-M transplantation promoted the reduction of the amyloid beta[37-42]plaque number and size in the cortex and hippocampus of the treated mice,but no change in the more heavily modified pyroglutamate amyloid beta E3 plaques.The number of phenotypically‘small’microglia increased in the hippocampus.Astrocyte size decreased overall,indicating a reduction of activated astrocytes.Gene expression of interleukin 6 and 10,interferongamma,and prostaglandin E receptor 2 was significantly lower in the hippocampus,while interleukin 10 expression was elevated in the cortex of the treated mice.Conclusions:BM-M systemically transplanted,promote a decrease in neuroinflammation and a limited reversion of amyloid pathology.This exploratory study may support the potential of BM-M or microglia-like cell therapy and further illuminates the mechanisms of action associated with such transplants.	Luís Costa-Marques Katrin Arnold Marie-Christine Pardon Christiane Leovsky Samantha Swarbrick Claire Fabian Alexandra Stolzing	2019	Translational Neurodegeneration2019，8，1：	1

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