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您的检索式：作者名="Chris Setchell"
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| 1 | Whole-body heat exposure induces membrane changes in spermatozoa from the cauda epididymidis of laboratory mice显示文摘这研究被执行决定到热环境温度的暴露是否在精子质量上有直接、有害效果。为这,实验室老鼠的 epididymal 精子上的整个身体的热暴露的效果被调查。C57BL/6 鼠标(n = 7 ) 是在在 37 掳 C 鈥 ? 的一个小气候房间的 housed 为 8 h 的 8 掳 C 每为三连续的天的天,当时控制鼠标(n = 7 ) 在 23 掳 C 被保留鈥 ? 4 掳 C。尾 epididymal 精子被获得在最后热处理以后的 16 h。结果证明精子号码在二个组是类似的(P = 0.23 ) ,但是在热处理以后,在能动精子的百分比的重要减小是在场的(P < 0.0001 ) 。精子的膜变化被与结合的藻红朊(PE ) 染色 Annexin V 调查,它检测 phosphotidylserine 的 exteriorization 从对精子血浆膜,和 7-aminoactinomycin D (7-AAD ) 的外部传单内部,当血浆膜被损坏时,它绑在精子原子核。显示出与 Annexin V 鈥揚E 或 7-AAD 或两个的积极染色的精子的百分比,显著地更高(P < 0.05 ) 在暴露热的老鼠与控制相比。这些结果显示出那整个身体的热暴露到 8 掳 C 导致的 37 掳 C 鈥 ? 膜在老鼠的 epididymal 精子变化,它可以导致 apoptosis。 | Harsha Wechalekar Brian P. Setchell Eleanor J. Peirce Mario Ricci Chris Leigh William G. Breed | 2010 | Asian Journal of Andrology2010，12，4： | 4 |
| 2 | Innovation Portfolio Management for Small-medium Enterprises显示文摘For small and medium sized enterprises,portfolio management can be a difficult exercise;especially when the available paths forwards are shrouded in mystery.To overcome this,they are required to research and decide upon the path to follow,but this can be difficult when the information to gather is unclear,leading to ad-hoc processes and inconsistency.The motivation for this project originated from a small and medium sized enterprise experiencing this problem of unknown critical information and a technological portfolio with significant potential.With no procedure or method in place,they conducted the research in an ad-hoc way resulting in uncertainty and low repeatability of decisions.To tackle this problem,innovation structuring frameworks were synthesised with appropriate risks and context to pose a new structure for information capture.The resulting structure was tested within the small and medium sized enterprise to investigate the repeatability of the information capture and the subsequent ranking.The proposed structure was also analysed by-process experts for its wider applicability.For the small and medium sized enterprise,this led to a consistent and repeatable method that delivered increased confidence about selecting a path forwards for its portfolio.In addition,it was found to be applicable to external organisations increasing the moders worth and applicability.The implications of this work have led to a change in the operational procedure of the small and medium sized enterprise to utilise the defined process for researching new ideas for their portfolio which can lead to repeatable and trustworthy decisions.This also has applicability to other similar companies and could lead them through a repeatable process as presented here. | Daniel Pashley Theo Tryfonas Andy Crossley Chris Setchell Stylianos Karatzas | 2020 | Journal of Systems Science and Systems Engineering2020，29，5： | 2 |
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